Active B-Complex
Integrative Therapeutics
Active B-Complex
4.8
★ ★ ★ ★ ★
(133 ratings)
Vitamin B5 100 mg
Choline 250 mg
Thiamin 50 mg
Vitamin B12 1000 mcg
Biotin 300 mcg
Vitamin B6 50 mg
Niacin 100 mg
Score 82.0
An 'active' B-complex offering preferred forms of B6 and B12, plus strong doses of choline and inositol for brain support. Its effectiveness is slightly hampered by standard forms of Thiamine and unspecified (likely non-active) Folate.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Skin Health
Stress Relief
Energy
Brain Health
Cognitive Support
leaderboard Score 82.0
An 'active' B-complex offering preferred forms of B6 and B12, plus strong doses of choline and inositol for brain support. Its effectiveness is slightly hampered by standard forms of Thiamine and unspecified (likely non-active) Folate.
insights Analysis
This 'Active B-Complex' from Integrative Therapeutics features beneficial active forms such as Pyridoxal 5-Phosphate (P5P) for B6 and Methylcobalamin for B12, both highly preferred for their direct usability. It also wisely includes both Riboflavin and Riboflavin 5-Phosphate for B2, and a substantial 250mg each of Choline Bitartrate and Inositol, which are excellent for brain health and liver function. However, the designation 'Folate, Form: null' is a notable drawback for an 'active' complex, as it usually implies folic acid, which many individuals struggle to convert to its active form (L-Methylfolate). Thiamine is also in the standard Hydrochloride form. Despite these minor inconsistencies in its 'active' claim, the strengths in B6, B12, choline, and inositol make it a strong contender for cognitive and general B vitamin support, though its price is on the higher side.
- Features active and highly bioavailable forms of Vitamin B6 (P5P) and Vitamin B12 (Methylcobalamin), ensuring efficient utilization.
- Provides a very high dose of Choline (250mg) and Inositol (250mg), which are excellent for brain health, cognitive function, and liver support.
- Includes a combination of standard and active Riboflavin (B2) forms for comprehensive energy metabolism.
- Niacin is supplied as Niacinamide, which is a non-flushing form, enhancing user comfort.
- The form of Folate is listed as 'null', likely indicating folic acid, which is not the active form (L-Methylfolate) and may not be optimally metabolized by all individuals, especially those with MTHFR gene variations.
- Thiamine (B1) is provided as Thiamine Hydrochloride, a standard form, rather than a more bioavailable option like Benfotiamine.
- Higher price per serving compared to many standard B-complexes, despite not being fully active across all B vitamins.
- While generally safe, high doses of Choline can sometimes cause a 'fishy' body odor in some individuals.
$18.00($0.30 per serving)
 Pure Formulas | $ 18.00 |
bolt Effectiveness for goals
B-vitamin complexes contribute to various essential bodily functions, including energy production, metabolism of carbohydrates, fats, and proteins, and the synthesis of red blood cells. They play a crucial role in maintaining overall cellular health. Many B vitamins also support neurological function and help reduce fatigue.
B vitamins act as coenzymes in metabolic pathways that convert food into energy. Thiamine, Riboflavin, Niacin, Pantothenic Acid, and Biotin are particularly important for breaking down carbohydrates, fats, and proteins to generate ATP, the body's main energy currency. They facilitate reactions vital for cellular respiration.
Active forms of B vitamins, such as Methylcobalamin (B12), Pyridoxal 5-Phosphate (B6), and Riboflavin 5-Phosphate (B2), are already in a form the body can readily use. This means they do not require conversion by the liver, which can be beneficial for individuals with genetic variations or impaired conversion abilities. It may allow for more efficient utilization of the nutrient.
Folate and Vitamin B12 have a synergistic relationship, especially in the methylation cycle and the synthesis of DNA. B12 is required to convert Folate into its active form, which is essential for DNA synthesis and repair. Together, they are critical for red blood cell formation and neurological health.
Choline is vital for liver function, brain development, nerve function, and metabolism. Inositol is involved in cell signaling processes and can support mood regulation. Both are important components of cell membranes and contribute to neurotransmitter synthesis, supporting cognitive function and nerve health.
schedule Dosage, timing & forms
B-complex supplements are commonly taken once daily, usually with a meal to enhance absorption and minimize potential stomach upset. Following the specific instructions provided by the manufacturer on the product label is generally recommended.
Many individuals prefer to take B vitamins in the morning, as they play a role in energy metabolism and may provide a stimulating effect. However, some people take them with their largest meal of the day. Consistency is often more important than the exact time.
Supplements may include both Pyridoxine Hydrochloride and Pyridoxal 5-Phosphate (P-5-P) for Vitamin B6. P-5-P is the biologically active form that the body can readily utilize, while Pyridoxine HCl needs to be converted into P-5-P. Providing both can support broader availability and potential benefits.
Methylcobalamin is one of the two coenzyme (active) forms of Vitamin B12 naturally found in the body. It is readily utilized by the body and does not require conversion, making it a preferred form for many B12 supplements due to its direct bioavailability.
Taking B vitamins with food is generally recommended. This can help prevent stomach upset that some individuals might experience on an empty stomach and may also improve the absorption of these water-soluble nutrients.
health_and_safety Safety & interactions
B vitamins are generally well-tolerated at recommended doses. Occasionally, individuals may experience mild stomach upset, nausea, or diarrhea. High doses of certain B vitamins, like B6, can lead to specific side effects such as nerve damage, while Niacin in its nicotinic acid form can cause flushing.
Yes, it is common for urine to turn a bright yellow or orange color after taking B vitamins, particularly those containing riboflavin (Vitamin B2). This effect is harmless and occurs as the body excretes excess riboflavin. It indicates that the body has absorbed what it needs and is eliminating the rest.
Yes, certain B vitamins can interact with medications. For example, high doses of vitamin B6 (pyridoxine) might interfere with some Parkinson's disease medications or certain anticonvulsants. Niacin can interact with cholesterol-lowering drugs and blood pressure medications, though the niacinamide form generally has fewer such interactions. Consulting a healthcare professional regarding potential interactions is advisable.
Yes, high doses of biotin can interfere with certain lab tests, especially those that use biotin technology for assays like thyroid hormones, cardiac troponin, and some hormone levels. This interference can lead to falsely high or low results, which may impact diagnosis and treatment. It is important to inform your healthcare provider about biotin supplementation before any lab tests.
No, the Niacinamide form of Niacin, also known as nicotinamide, typically does not cause the 'niacin flush.' This flush, characterized by skin redness, warmth, itching, or tingling, is primarily associated with nicotinic acid, another form of niacin. Niacinamide is generally well-tolerated without this common side effect.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Total Carbohydrates | 1 Gram(s) |
| Thiamine (Thiamine Hydrochloride) | 50 mg |
| Riboflavin (Vitamin B2, Riboflavin 5-Phosphate) | 50 mg |
| Niacin (Niacinamide) | 100 mg |
| Vitamin B6 (Pyridoxine Hydrochloride, Pyridoxal 5-Phosphate) | 50 mg |
| Folate | 800 mcg DFE |
| Vitamin B12 (Methylcobalamin) | 1000 mcg |
| Biotin | 300 mcg |
| Pantothenic Acid (Calcium D-Pantothenate) | 100 mg |
| Choline (Choline Bitartrate) | 250 mg |
| Inositol | 250 mg |
Categories
Vitamin B12 100.0
Contains 1000mcg of Methylcobalamin, the active and highly bioavailable form of B12, ensuring optimal absorption and direct utilization by the body for energy and nerve health.
Vitamin B6 95.0
Features a combination of 50mg Pyridoxine Hydrochloride and 50mg Pyridoxal 5-Phosphate (P5P). The inclusion of the active P5P significantly enhances its usability and effectiveness.
Choline 95.0
Delivers an impressive 250mg of Choline Bitartrate, providing substantial support for brain health, memory, neurotransmitter synthesis, and liver function.
Goals
Brain Health 90.0
The high doses of choline and inositol, combined with active B6 and B12, make this product exceptionally well-suited for supporting neurotransmitter synthesis, nerve health, and overall brain function.
Cognitive Support 90.0
This product is particularly strong for cognitive support due to high doses of choline and inositol, coupled with bioavailable B6 and B12, which are essential for memory, focus, and mental clarity.
Mental Focus 90.0
High doses of choline and inositol work synergistically with active B6 and B12 to promote sharp mental focus and concentration, making it highly effective for cognitive tasks.
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