Product Image

Coenzymate B Complex Peppermint

Source Naturals
4.6
★ ★ ★ ★ ★
(510 ratings)
Niacin 39 mg
Vitamin B12 870 mcg
Riboflavin 10 mg
Vitamin B5 25 mg
Thiamin 13 mg
Coenzyme Q-10 12 mg
Product Image
Score70
Strong coenzyme B-vitamin forms in a convenient lozenge, with unnecessary label complexity and too little CoQ10 to matter much.
How scoring works
Quantity:60 Liquid(s) • (30 servings)
Goals:
General Health
Energy
Metabolism Boost
Brain Health
Cognitive Support
Hair Health

Score 70

Strong coenzyme B-vitamin forms in a convenient lozenge, with unnecessary label complexity and too little CoQ10 to matter much.
How scoring works

Also available as

1 option
Orange Flavored 2 Lozenge(s) • 60 Liquid(s) • 30 servings $20.19 ($0.67 per serving)
$18.90($0.63 per serving)
Vitacost
$ 19.15
Amazon
$ 18.90
iHerb
$ 21.14
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Analysis

Methylcobalamin, hydroxocobalamin, flavin mononucleotide, and P-5-P give the formula a strong active-form foundation. The lozenge format is convenient and well aligned with users who prefer not to swallow capsules.

The combined B12 listing does not clarify how much each form contributes, and the multiple niacin sources make the label harder to interpret. Ubiquinone is present at only 12 mg, which is too little to make the product a meaningful CoQ10 supplement.

The blend best fits foundational B-vitamin and non-stimulant energy support. It may help when nutrient status is low, but it lacks a direct alertness, memory, hair-structure, or thermogenic pathway.

Who is it for
  • Adults seeking active B-vitamin forms
  • Users who prefer a lozenge
  • People wanting non-stimulant metabolic support
Best for
  • B-vitamin supplementation
  • Normal energy metabolism
  • Methylcobalamin and hydroxocobalamin intake

Pros

  • Uses methylcobalamin and hydroxocobalamin
  • Includes active riboflavin and B6
  • Convenient lozenge format
  • Provides broad B-vitamin coverage

Cons

  • Individual B12-form contributions are unclear
  • Multiple niacin sources complicate the label
  • CoQ10 is only a token addition
  • Uses folic acid rather than methylfolate

Nutrient quality

78 High impact

Active riboflavin, P5P, hydroxocobalamin, and methylcobalamin provide favorable form quality. Core B vitamins are meaningful, while CoQ10 and inositol are too small to contribute much.

Ingredient transparency

71 High impact

Most actives have amounts, but niacin and vitamin B12 totals repeat across several forms. Daily directions and the complete liquid base are not supplied.

Customer satisfaction

68 High impact

The aggregate rating is strong and supported by a useful number of ratings. No detailed experience reports are supplied, so recurring complaints and purpose fit remain uncertain.

Value for money

60 Moderate impact

Specialized B-vitamin forms add some premium value. Low CoQ10, ambiguous totals, and a relatively high serving cost weaken category competitiveness.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportA- CoverageB+ Formula Quality
Folate · 680 mcg DFEVitamin B12 · 870 mcgVitamin C · 17 mg

Active B-vitamin forms and broad coverage make the lozenge well aligned with cellular energy and nerve support. Methylcobalamin, hydroxocobalamin, flavin mononucleotide, and pyridoxal phosphate strengthen the formulation.

The label does not clarify the amount contributed by each B12 form, and the repeated niacin sources add complexity. It suits broad B-vitamin support better than a user seeking a simple, single-nutrient product.

Study evidence
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
Highest effect
A Goal FitA Strength of SupportB CoverageB Formula Quality
Vitamin B5 · 25 mgRiboflavin · 10 mgThiamin · 13 mgVitamin B12 · 870 mcgCoenzyme Q-10 · 12 mg

Active-form B vitamins support multiple steps in fuel metabolism, and the high B12 amount exceeds the goal's functional threshold. Methylcobalamin, hydroxocobalamin, activated riboflavin, and activated vitamin B6 strengthen the metabolic design.

The small ubiquinone addition is unlikely to provide meaningful standalone mitochondrial support and lacks lipid delivery. Multiple forms of niacin and B12 add some redundancy, but most of the formula remains coherent for non-stimulant metabolic energy.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Riboflavin Mixed 6 studies
Vitamin B12 Disputed 14 studies
Metabolism Boost
Metabolic B-Vitamins
Metabolism Boost
Impact
High effect
B- Goal FitB Strength of SupportC CoverageA- Formula Quality
Biotin · 150 mcgNiacin · 39 mgVitamin B12 · 870 mcgRiboflavin · 10 mgThiamin · 13 mgVitamin B5 · 25 mgVitamin B6 · 10 mgCoenzyme Q-10 · 12 mg

Coenzymated riboflavin, vitamin B6, bioactive vitamin B12, and niacin forms support cellular energy reactions. Ubiquinone adds mitochondrial relevance, though its small amount is unlikely to contribute much.

The lozenge provides favorable forms with generally clear disclosure. Its strong B-vitamin foundation remains more useful for nutrient adequacy than for directly raising metabolic rate.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Niacin Supportive 17 studies
Riboflavin Mixed 5 studies
Vitamin B12 Supportive 10 studies
Vitamin B6 Supportive 16 studies
Brain Health
Essential Brain Nutrition
Brain Health
Impact
High effect
B- Goal FitB Strength of SupportC CoverageB+ Formula Quality
Folate · 680 mcg DFEVitamin B12 · 870 mcgVitamin B6 · 10 mgThiamin · 13 mg

Bioactive B12 forms, active B6, riboflavin, and thiamin support neurological maintenance and brain energy metabolism. The lozenge format also suits oral contact for B12, making the foundational nutrient design stronger than a basic B-complex.

The formula still focuses on correcting or preventing nutrient shortfalls rather than directly supporting memory or attention. Folic acid and an unspecified thiamin form keep the ingredient quality from being uniformly strong.

Study evidence
Thiamin Supportive 48 studies
Vitamin B12 Supportive 74 studies
Cognitive Support
Cognitive Support
Impact
High effect
C- Goal FitB- Strength of SupportC- CoverageB+ Formula Quality
Thiamin · 13 mgVitamin B6 · 10 mgFolate · 680 mcg DFEVitamin B12 · 870 mcg

Active B-vitamin forms support energy and neurotransmitter metabolism, especially when nutrient status is inadequate. The lozenge provides strong disclosure, but it lacks a central memory, attention, or circulation active.

CoQ10 adds modest cellular-energy support while the formula remains primarily a B-complex. It offers coherent nutritional support rather than a direct nootropic intervention.

Hair Health
Hair Health
Impact
High effect
D+ Goal FitB Strength of SupportC- CoverageB- Formula Quality
Biotin · 150 mcgVitamin C · 17 mg

Active B-vitamin forms and biotin may support hair when a relevant nutrient deficiency is present. They offer limited evidence for improving growth in otherwise well-nourished users.

The formula provides broad B-vitamin coverage with clear amounts and several coenzyme forms. It lacks structural proteins, minerals, or targeted follicle botanicals, so hair support remains indirect.

Study evidence
Biotin Supportive 4 studies
Niacin Disputed 2 studies
Productivity Boost
Productivity Boost
Impact
Moderate effect
D+ Goal FitB+ Strength of SupportC- CoverageC+ Formula Quality
Vitamin B12 · 870 mcgVitamin B12 · 870 mcgVitamin B6 · 10 mg

Active B-vitamin forms may support cellular energy and concentration when low B-vitamin status contributes to fatigue. The blend is foundational rather than a direct nootropic and is unlikely to create an acute focus effect in well-nourished users.

Methylcobalamin, hydroxocobalamin, pyridoxal 5-phosphate, and flavin mononucleotide improve form quality, while the lozenge format supports convenient use. The combined listing of multiple B12 and niacin forms makes individual contributions unclear, and the broader blend adds limited pathway diversity.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies

Ingredients

IngredientAmount per serving
Total Carbohydrates
1 Gram(s)
Vitamin C (Niacinamide Ascorbate)
 17 mg
Thiamine (Vitamin B1)
 13 mg
Riboflavin (Flavin Mononucleotide)
 10 mg
Niacin (Inositol Hexanicotinate, Niacinamide Ascorbate, Nicotinamide Adenine Dinucleotide)
 39 mg
Vitamin B-6 (Pyridoxal 5-Phosphate)
 10 mg
Folate (Folic Acid)
 680 mcg DFE
Vitamin B12 (Hydroxocobalamin, Methylcobalamin)
 870 mcg
Biotin
150 mcg
Pantothenic Acid (Calcium D-Pantothenate)
 25 mg
Coenzyme Q10 (Ubiquinone)
 12 mg
Inositol (Inositol Hexanicotinate)
 7 mg
Adults 18–50
Report overview
Niacin (Inositol Hexanicotinate, Niacinamide Ascorbate, Nicotinamide Adenine Dinucleotide) · 39 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD- Value

inositol hexanicotinate, niacinamide ascorbate, and NAD is a reasonable form for a general multivitamin or B-complex without a specialized NAD-plus claim. The 39 mg serving is appropriate for a multivitamin or B-complex. The serving cost is high, though several coenzyme-form B vitamins add value beyond niacin.

View ingredientView products
Vitamin B12 (Hydroxocobalamin, Methylcobalamin) · 870 mcg OverallScore70
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

The lozenge combines methylcobalamin and hydroxocobalamin, giving it fully bioactive B12 forms with a delivery method suited to oral mucosal contact. The total B12 amount provides substantial support but falls just below the higher-dose threshold, and the label does not show how much of each form is present. Its cost is high when judged only by B12 delivered, although the broader coenzyme B-complex formula adds utility beyond this collection.

View ingredientView products
Riboflavin (Flavin Mononucleotide) · 10 mg OverallScore66
A+ Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyD+ Value

Flavin Mononucleotide provides the bioactive coenzyme form, although the label does not separate elemental riboflavin from compound weight. The dose is suited to low-level maintenance, while the liquid format supports efficient release. The premium form partly offsets a relatively high per-serving cost.

View ingredientView products
Loading alternative details
77 Performance

Coenzymate B Complex Orange Flavored

Source Naturals
<p>Coenzyme forms across several B vitamins provide strong absorption potential with balanced pyridoxine. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although folic acid is less active than methylfolate.</p>
83 Performance

Multi-B Benfotiamine 150 mg

BenfoComplete.com
<p>Benfotiamine and methylcobalamin add strong form quality to a practical B-vitamin blend. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although the high pyridoxine amount is less suitable for long-term daily use.</p>
85 Performance

B-Complex Plus

Pure Encapsulations
<p>Methylfolate, methylcobalamin, P-5-P, and activated riboflavin create a focused, well-balanced B-complex. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although the high pyridoxine amount is less suitable for long-term daily use.</p>
84 Budget

Super B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
<p>A broad, inexpensive B-complex provides sensible amounts for everyday energy metabolism without the extreme dosing seen in many high-potency formulas. Its lower serving cost improves value compared with the original, although cyanocobalamin is a conventional B12 form.</p>
67 Budget

B 100 Complex

Spring Valley
<p>A very inexpensive tablet supplies a broad set of B vitamins at substantial amounts. Its lower serving cost improves value compared with the original, although its concentrated doses are more appropriate for deliberate use than casual stacking.</p>
80 Budget

B-Complex '100'

Solgar
<p>A broad high-potency B-vitamin profile supports normal energy metabolism, but most forms are conventional and several amounts greatly exceed routine needs. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
83 Value

High Potency Vitamin B Complex

Lake Avenue Nutrition
<p>Active riboflavin, P-5-P, methylfolate, and methylcobalamin create a high-quality, long-supply B-complex. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
79 Value

B-100 Complex

21st Century
<p>A broad high-potency B-vitamin profile supports normal energy metabolism, but most forms are conventional and several amounts greatly exceed routine needs. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
80 Value

B-100 Complex with B2 Coenzyme

Nature's Way
<p>Active riboflavin and partial P-5-P improve this otherwise conventional high-potency B-complex. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Can thiamine substitution restore cognitive function in alcohol use disorder?
    Listabarth S; Vyssoki B; Marculescu R; Gleiss A; Groemer M; Trojer A; Harrer C; Weber S; König D · Alcohol and alcoholism (Oxford, Oxfordshire) · 2023
    Clinical trial50 participantsBrain Health forThiamin
  2. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.
    Galvin R; Bråthen G; Ivashynka A; Hillbom M; Tanasescu R; Leone MA; EFNS · European journal of neurology · 2011
    Guideline / consensusBrain Health forThiamin
  3. Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review.
    Cantu-Weinstein A; Branning R; Alamir M; Weleff J; Do M; Nero N; Anand A · General hospital psychiatry · 2024
    Systematic review688 participants27 studies pooledBrain Health forThiamin
  4. Vitamin Supplementation and Dementia: A Systematic Review.
    Gil Martínez V; Avedillo Salas A; Santander Ballestín S · Nutrients · 2022
    Systematic reviewBrain Health forThiamin
  5. Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
    Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
    Cross-sectional study2,422 participantsBrain Health forThiamin
  6. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  7. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health forVitamin B12
  8. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  9. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  10. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  11. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  12. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  13. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  14. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  15. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  16. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  17. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  18. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  19. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  20. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  21. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  22. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  23. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  24. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  25. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  26. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  27. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  28. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  29. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  30. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  31. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  32. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  33. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  34. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  35. A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia.
    Draelos ZD; Jacobson EL; Kim H; Kim M; Jacobson MK · Journal of cosmetic dermatology · 2009
    Randomized trial60 participantsHair Health forNiacin
  36. Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia.
    Watanabe Y; Nagashima T; Hanzawa N; Ishino A; Nakazawa Y; Ogo M; Iwabuchi T; Tajima M · International journal of cosmetic science · 2016
    Randomized trial102 participantsHair Health forNiacin
  37. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  38. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  39. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  40. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledMetabolism Boost forCoenzyme Q-10
  41. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10
  42. Niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Boost forNiacin
  43. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
    Fangmann D; Theismann EM; Türk K; Schulte DM; Relling I; Hartmann K; Keppler JK; Knipp JR; Rehman A; Heinsen FA; Franke A; Lenk L; Freitag-Wolf S; Appel E; Gorb S; Brenner C; Seegert D; Waetzig GH; Rosenstiel P; Schreiber S; Schwarz K; Laudes M · Diabetes care · 2018
    Clinical trialMetabolism Boost forNiacin
  44. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.
    Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frézal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B · Nature metabolism · 2026
    Randomized trial65 participantsMetabolism Boost forNiacin
  45. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance.
    Linke A; Sonnabend M; Fasshauer M; Höllriegel R; Schuler G; Niebauer J; Stumvoll M; Blüher M · Atherosclerosis · 2009
    Randomized trial30 participantsMetabolism Boost forNiacin
  46. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
    Vaag A; Skött P; Damsbo P; Gall MA; Richter EA; Beck-Nielsen H · The Journal of clinical investigation · 1991
    Clinical trial12 participantsMetabolism Boost forNiacin
  47. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  48. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  49. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  50. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  51. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).
    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  52. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  53. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  54. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
  55. Diagnosis and treatment of vitamin B12 deficiency in children.
    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12
  56. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  57. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  58. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  59. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  60. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6
  61. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  62. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  63. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  64. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  65. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  66. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  67. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  68. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  69. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12