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Vitamin D3 5000 IU With Vitamin K2 Natural Apricot Flavor

Michael's Naturopathic Programs
4.9
★ ★ ★ ★ ★
(12832 ratings)
Vitamin K 90 mcg
Vitamin D 5000 IU
Product Image
Score85
Well-disclosed D3 and MK-7 provide focused bone and cardiovascular support in one tablet. High vitamin D potency and the K2 interaction with vitamin K antagonists are the main considerations.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
General Health
Heart Health
Cardiovascular Support
Bone Health
Anti-Aging
Testosterone Support
Anti-Inflammatory Support
Immunity
Joint Health
Energy

Score 85

Well-disclosed D3 and MK-7 provide focused bone and cardiovascular support in one tablet. High vitamin D potency and the K2 interaction with vitamin K antagonists are the main considerations.
How scoring works
$23.91($0.26 per serving)
Pure Formulas
$ 23.91
Vitacost
$ 23.91
iHerb
$ 23.91
Amazon
$ 23.91
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Analysis

Each tablet supplies 5,000 IU of vitamin D3 from lanolin and 90 mcg of vitamin K2 as MK-7. The forms are stated clearly and address vitamin D status and calcium handling through complementary pathways.

A one-tablet serving and 90-day supply make daily use simple. The apricot flavor may help users who dislike plain tablets, though the supplied data do not describe sweeteners or other excipients.

The formula is most appropriate for adults with a reason to use higher-dose vitamin D rather than those seeking a minimal maintenance amount. Medication review is important because MK-7 directly affects vitamin K intake.

Who is it for
  • Adults seeking a combined D3 and MK-7 product
  • People following a higher-potency vitamin D plan
  • Users who prefer one flavored tablet daily
Best for
  • Bone and calcium support
  • Clearly specified vitamin K2
  • One-tablet convenience

Pros

  • Uses vitamin D3 from an identified source
  • Specifies vitamin K2 as MK-7
  • Provides useful amounts of both actives
  • Offers 90 single-tablet servings

Cons

  • Vitamin D potency may be more than some users need
  • The supplied data do not show full excipient details
  • The tablet format provides no stated fat-based delivery support

Warnings

  • MK-7 can counter vitamin K antagonist medicines such as warfarin; use requires consistent intake and prescriber guidance.
  • The 5,000 IU vitamin D3 serving can make total intake high when combined with other vitamin D products.

Nutrient quality

90 Highest impact

Lanolin-sourced vitamin D3 and MK-7 are well-regarded, clearly identified forms. The vitamin D serving is above the usual adult upper intake level and is better suited to monitored use.

Ingredient transparency

86 Highest impact

Both active nutrients have specific amounts. No proprietary blend hides either active dose; daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

74 High impact

The supplied rating is strong, with substantial volume behind it. Detailed feedback themes are absent, leaving repeated complaints and purpose fit uncertain.

Value for money

88 Highest impact

Clear forms and useful doses justify much of the serving cost. The serving cost is reasonable for a combined D3 and MK-7 product.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A+ Goal FitA- Strength of SupportB+ CoverageA+ Formula Quality
Vitamin D · 5000 IUVitamin K · 90 mcg

Vitamin D3 and MK-7 vitamin K2 provide complementary support for bones, calcium handling, muscles, and immune function. Both nutrients are supplied in clearly identified forms and substantial amounts.

The vitamin D amount is relatively high for routine daily use and may be most appropriate when intake needs are known. Vitamin K2 can oppose warfarin and related vitamin K antagonist medicines, so users of those drugs should not change vitamin K intake without prescriber guidance.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Heart Health
Heart Health
Impact
Highest effect
A- Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 90 mcgVitamin D · 5000 IU

Vitamin K2 as MK-7 directly supports calcium handling in blood vessels, while vitamin D3 provides complementary signaling. Both actives are clearly disclosed at meaningful amounts.

The pairing is coherent, though no lipid carrier or independent verification is provided. Vitamin K2 can oppose warfarin’s anticoagulant effect, so people using warfarin need prescriber guidance before use.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 90 mcgVitamin D · 5000 IU

Vitamin D3 and MK-7 vitamin K2 form a strong calcium-management pairing relevant to arterial health. Both nutrient forms and amounts are clearly disclosed.

The dry sublingual tablet lacks a lipid carrier, and the vitamin D amount is high for routine unsupervised use. Vitamin K2 can counteract warfarin and related vitamin K antagonists, making consistent clinician-guided intake important.

Study evidence
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies
Bone Health
Bone Health
Impact
Highest effect
A Goal FitA- Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 90 mcgVitamin D · 5000 IU

Vitamin D3 and MK-7 vitamin K2 form a well-targeted pair for calcium absorption and movement into bone tissue. Both forms are clearly identified and directly relevant to long-term skeletal maintenance.

The formula does not supply calcium, magnesium, or protein-matrix support, so it works best as a cofactor supplement rather than a complete bone formula. Vitamin K2 can interfere with warfarin and other vitamin-K-antagonist anticoagulants, while the high vitamin D amount may require attention to total intake.

Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 90 mcgVitamin D · 5000 IU

Vitamin D3 with MK-7 vitamin K2 offers complementary support for bone strength and calcium handling with age. Both forms and amounts are clearly disclosed, and human evidence supports their physiological roles.

The serving provides substantial vitamin D3 and a clinically aligned MK-7 amount, though the dry tablet has no lipid carrier. Vitamin K2 can oppose warfarin's anticoagulant effect, so users of that medicine need prescriber guidance before changing intake.

Study evidence
Vitamin D Supportive 50 studies
Vitamin K Supportive 27 studies
Testosterone Support
Testosterone Support
Impact
Highest effect
A- Goal FitA Strength of SupportC CoverageA Formula Quality
Vitamin D · 5000 IU

Vitamin D3 directly supports a foundational endocrine pathway, and the 5000 IU amount is substantial enough to correct low intake. Vitamin K2 adds a complementary nutrient but does not broaden testosterone support.

The lanolin source and MK-7 form are clearly disclosed, while the sublingual tablet lacks a stated fat carrier. The higher daily amount may be more than some people need, so long-term use is best guided by vitamin D blood levels.

Study evidence
Vitamin D Supportive 56 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Lanolin)
 5000 IU
Vitamin K2 (Menaquinone 7)
 90 mcg
Gluten Free Adults 18–50 Kosher Dairy Free Sugar Free
Report overview
Vitamin K (Menaquinone 7) · 90 mcg OverallScore87
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The clearly identified MK-7 form and clinically aligned dose support bone and cardiovascular goals. Generic sourcing and the absence of a lipid base or fat-containing meal direction limit quality assurance and absorption support. Cost efficiency is strong, though the vitamin K2 amount may oppose warfarin's anticoagulant effect.

View ingredientView products
Vitamin D (Lanolin) · 5000 IU OverallScore76
B+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyB+ Value
+2

Lanolin-sourced vitamin D3 offers clear traceability, though the sublingual tablet has no listed lipid carrier. The 5000 IU serving sits within the preferred daily range. No flagged additives are disclosed, and MK-7 vitamin K2 helps the value, though independent verification is absent.

View ingredientView products
Loading alternative details
89 Performance

Mega D-3 5000 IU & MK-7 180 mcg

NOW
<p>A branded MK-7 source is disclosed separately at 180 mcg alongside 5,000 IU vitamin D3, improving vitamin K clarity and amount. The formula remains high-dose and the dry capsule lacks stated fat-intake guidance, so measured need still matters.</p>
87 Performance

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Natural Factors
<p>A moderate 1,000 IU vitamin D3 amount and 120 mcg MK-7 create a balanced maintenance option for bone and cardiovascular support. Duplicate K2 source entries add minor ambiguity, but the vitamin D amount is easier to fit into routine intake than 5,000 IU.</p>
86 Performance

Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

NaturesPlus
<p>Clearly identified MK-7 and 2,500 IU vitamin D3 provide a balanced middle ground with strong bone-support alignment. The dry tablet has no stated lipid carrier, but active disclosure and dosing are clearer than a combined vitamin K entry.</p>
86 Budget

Vitamin K2 100 mcg + Vitamin D3 125 mcg

Nutricost
<p>Clearly identified MK-7 is paired with 5,000 IU vitamin D3 in a softgel at a much lower ongoing cost. The vitamin D amount remains high for routine unsupervised use, but vitamin K disclosure is more useful than a combined K1 and K2 entry.</p>
86 Budget

Liquid D-3 & MK-7

NOW
<p>Liquid vitamin D3 and 100 mcg MK-7 provide both core nutrients with flexible delivery and much lower ongoing cost. The 2,500 IU vitamin D amount is more moderate than a 5,000 IU formula, while vitamin K can still conflict with warfarin-type medicines.</p>
86 Budget

Liquid Vitamin D3 Drops 5000 IU Natural Citrus Flavor

Bluebonnet
<p>Liquid lanolin-derived vitamin D3 matches the high-dose vitamin D component at a very low ongoing cost. It does not replace vitamin K, and the concentrated amount is better matched to a measured need than routine unsupervised maintenance.</p>
84 Value

D3 + K2

Nature Made
<p>All-trans MK-7 and vitamin D3 are fully separated and delivered in a focused softgel. The vitamin D amount is still high and the package is shorter, but the defined forms make the formula easier to assess.</p>
88 Value

Vitamin K2 MK-7 100 mcg

Nutricost
<p>A clearly identified 100 mcg MK-7 serving offers strong routine value for the vitamin K portion of the formula. Vitamin D would need to come from another source, and anyone using a vitamin K antagonist needs clinician-directed intake.</p>
85 Value

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
<p>Natto-derived MK-7 provides a clearly disclosed vitamin K2 form with economical long-term servings. It improves value and transparency for vitamin K, but it does not supply vitamin D and can conflict with warfarin-type medicines.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  2. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  3. Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.
    Witte KK; Byrom R; Gierula J; Paton MF; Jamil HA; Lowry JE; Gillott RG; Barnes SA; Chumun H; Kearney LC; Greenwood JP; Plein S; Law GR; Pavitt S; Barth JH; Cubbon RM; Kearney MT · Journal of the American College of Cardiology · 2017
    Randomized trial229 participantsHeart Health forVitamin D
  4. Effects of vitamin D supplementation on markers of vascular function after myocardial infarction--a randomised controlled trial.
    Witham MD; Dove FJ; Khan F; Lang CC; Belch JJ; Struthers AD · International journal of cardiology · 2014
    Randomized trial75 participantsHeart Health forVitamin D
  5. Vitamin D deficiency and risk of heart failure in patients with obstructive sleep apnea: a cohort analysis.
    Chang YJ; Weng HL; Hung KC; Ho CN; Lai YC; Wu JY; Chen IW · Frontiers in nutrition · 2026
    Cohort study36,497 participantsHeart Health forVitamin D
  6. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  7. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsHeart Health Cardiovascular Support forVitamin K
  8. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.
    Chen HG; Sheng LT; Zhang YB; Cao AL; Lai YW; Kunutsor SK; Jiang L; Pan A · European journal of nutrition · 2020
    Meta-analysis222,592 participants21 studies pooledHeart Health forVitamin K
  9. Vitamin K intake and all-cause and cause specific mortality.
    Zwakenberg SR; den Braver NR; Engelen AIP; Feskens EJM; Vermeer C; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Clinical nutrition (Edinburgh, Scotland) · 2018
    Cohort study33,289 participantsHeart Health forVitamin K
  10. Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women.
    Kristensen M; Kudsk J; Bügel S · European journal of nutrition · 2008
    Randomized trial31 participantsHeart Health forVitamin K
  11. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  12. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  13. Effects of vitamin D and high dairy protein intake on bone mineralization and linear growth in 6- to 8-year-old children: the D-pro randomized trial.
    Stounbjerg NG; Thams L; Hansen M; Larnkjær A; Clerico JW; Cashman KD; Mølgaard C; Damsgaard CT · The American journal of clinical nutrition · 2022
    Randomized trial200 participantsBone Health forVitamin D
  14. Vitamin D and HRT: no benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women. A 2.5-year randomized placebo-controlled study.
    Komulainen M; Tuppurainen MT; Kröger H; Heikkinen AM; Puntila E; Alhava E; Honkanen R; Saarikoski S · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1997
    Randomized trial464 participantsBone Health forVitamin D
  15. Impact of serum 25-hydroxyvitamin D levels on fragility fractures in patients undergoing chronic hemodialysis.
    Hori M; Takahashi H; Kondo C; Tokoroyama S; Kanda A; Furuhashi K; Mori Y; Shirasawa Y; Takeda A; Morozumi K; Maruyama S · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Cohort study292 participantsBone Health forVitamin D
  16. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  17. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  18. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  19. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  20. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  21. No effect of high-dose vitamin D supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes.
    Sollid ST; Hutchinson MY; Fuskevåg OM; Figenschau Y; Joakimsen RM; Schirmer H; Njølstad I; Svartberg J; Kamycheva E; Jorde R · Diabetes care · 2015
    Randomized trial511 participantsCardiovascular Support forVitamin D
  22. Effect of cholecalciferol supplementation on arterial stiffness: a systematic review and meta-analysis.
    Upala S; Sanguankeo A; Congrete S; Jaruvongvanich V · Scandinavian cardiovascular journal : SCJ · 2017
    Meta-analysis547 participants7 studies pooledCardiovascular Support forVitamin D
  23. Vitamin D status and Its association with haematological inflammatory indices and cardiometabolic risk profiles: a retrospective cross-sectional study.
    Al-Essa YM; Aljumah HK; Al Saeed ZY; AlQattan RA; Alquwayzani DY; Al-Yousef GK; Al Owdah AS; Alzuwayr MA; Elsheikh E · Frontiers in cardiovascular medicine · 2026
    Cross-sectional study1,100 participantsCardiovascular Support forVitamin D
  24. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  25. The relationship between vitamin K and peripheral arterial disease.
    Vissers LET; Dalmeijer GW; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Atherosclerosis · 2017
    Cohort study36,629 participantsCardiovascular Support forVitamin K
  26. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  27. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
    van den Heuvel EG; van Schoor NM; Lips P; Magdeleyns EJ; Deeg DJ; Vermeer C; den Heijer M · Maturitas · 2014
    Cohort study577 participantsCardiovascular Support forVitamin K
  28. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  29. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  30. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  31. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  32. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  33. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  34. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  35. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  36. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  37. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  38. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  39. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  40. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  41. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  42. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  43. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  44. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  45. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  46. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  47. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  48. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  49. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forVitamin D
  50. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  51. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  52. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D
  53. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  54. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  55. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  56. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  57. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  58. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  59. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  60. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  61. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  62. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  63. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  64. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  65. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  66. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  67. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  68. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  69. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  70. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K
  71. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  72. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  73. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  74. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  75. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  76. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis.
    Wang X; Cicuttini F; Jin X; Wluka AE; Han W; Zhu Z; Blizzard L; Antony B; Winzenberg T; Jones G; Ding C · Osteoarthritis and cartilage · 2018
    Randomized trial413 participantsJoint Health forVitamin D
  77. Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes: A Systematic Review and Meta-Analysis.
    Vivek K; Kamal R; Perera E; Gupte CM · JBJS reviews · 2024
    Meta-analysis146,054 participants10 studies pooledJoint Health forVitamin D
  78. Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis.
    Zhao ZX; He Y; Peng LH; Luo X; Liu M; He CS; Chen J · Aging clinical and experimental research · 2021
    Meta-analysis1,599 participants6 studies pooledJoint Health forVitamin D
  79. Baseline 25-hydroxyvitamin D levels predict the effects of vitamin D supplementation on joint symptoms and cartilage loss in patients with knee osteoarthritis.
    Wang T; Zheng S; Jin X; Cen H; Zhu Z; Han W; Wluka A; Cicuttini F; Cao P; Ding C · Rheumatology advances in practice · 2025
    Randomized trial413 participantsJoint Health forVitamin D
  80. The Efficacy and Safety of Disease-Modifying Osteoarthritis Drugs for Knee and Hip Osteoarthritis-a Systematic Review and Network Meta-Analysis.
    Yang W; Sun C; He SQ; Chen JY; Wang Y; Zhuo Q · Journal of general internal medicine · 2021
    Meta-analysis11,890 participants28 studies pooledJoint Health forVitamin D
  81. Low vitamin K status is associated with osteoarthritis in the hand and knee.
    Neogi T; Booth SL; Zhang YQ; Jacques PF; Terkeltaub R; Aliabadi P; Felson DT · Arthritis and rheumatism · 2006
    Cohort study672 participantsJoint Health forVitamin K
  82. Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis.
    Liao Z; Chang J; Zhu Z; Han W; Meng T; Zheng S; Tu L; Antony B; Winzenberg T; Wluka AE; Cicuttini F; Ding C · Arthritis care & research · 2023
    Cohort study259 participantsJoint Health forVitamin K
  83. Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study.
    Oka H; Akune T; Muraki S; En-yo Y; Yoshida M; Saika A; Sasaki S; Nakamura K; Kawaguchi H; Yoshimura N · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2010
    Cross-sectional study719 participantsJoint Health forVitamin K
  84. The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence.
    Chin KY · Nutrients · 2021
    Narrative reviewJoint Health forVitamin K
  85. Vitamin K deficiency is associated with incident knee osteoarthritis.
    Misra D; Booth SL; Tolstykh I; Felson DT; Nevitt MC; Lewis CE; Torner J; Neogi T · The American journal of medicine · 2013
    Cohort study1,180 participantsJoint Health forVitamin K
  86. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  87. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  88. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  89. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  90. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D