Two-Per-Day Capsules

Two-Per-Day Capsules

Life Extension4.7 (95,085 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 30 servings
Goals

About this product

Broad nutritional support is the clearest reason to choose this formula. B vitamins, folate, vitamin C and vitamin D can help fill dietary gaps relevant to normal energy metabolism, immune function and nervous-system function, but larger amounts do not establish more energy or better concentration when intake is adequate.

Several sources are clearly named, including methylcobalamin, methylfolate, potassium iodide and two zinc forms. The proportions of the zinc, selenium, B2 and B6 mixtures are missing, while some additional ingredient forms remain unclear. The magnesium contribution is limited in the selected-serving findings, and calcium is not established as a companion to vitamin D.

The smaller extras do not turn a multivitamin into a targeted supplement for every listed purpose. Alpha-lipoic acid contributes little at the selected amount, and the marigold and quercetin information does not establish reliable active amounts for their respective uses. Routine weight loss, hair regrowth, improved memory or broader toxin removal cannot be inferred from the nutrient mix.

Serving interpretation needs care because some findings use one capsule while the label panel describes two. The label lists 75 mg of B6 across two identified forms, an amount that warrants attention before combining supplements or planning ongoing use. The serving cost can offer useful value for broad nutrient coverage, although individual add-ons contribute uneven value.

Who is it for
  • Adults seeking broad nutritional support when several dietary gaps are plausible
  • People willing to check the capsule serving and overlapping nutrient intake
Best for
  • Covering multiple nutrient needs with one formula
  • Supporting normal nutrient-dependent energy metabolism

Pros

  • Combines B vitamins with nutrients relevant to normal immune function
  • Names several nutrient sources, including methylcobalamin and potassium iodide
  • Uses identified zinc forms with favorable form findings
  • Offers reasonable value for broad nutrient coverage

Cons

  • Multiple nutrient mixtures omit their component proportions
  • Small or unresolved extras limit its appeal for targeted goals
  • Limited magnesium contribution and no established calcium companion
  • Some form and amount findings remain uncertain

Warnings

  • The label lists 75 mg of vitamin B6; check other B6 supplements and review ongoing use because the amount is high for routine nutritional support.
  • One-capsule findings and the two-capsule label panel refer to different servings; confirm the actual capsule count before using the listed amounts to plan intake.

Product analysis

57 out of 100

Two-Per-Day Capsules provides vitamins and minerals for normal metabolism, blood formation and immune function when intake is low. Several mixtures lack component breakdowns, making the contribution of individual forms harder to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality51

Several B vitamins, iodine, zinc and manganese have favorable or clearly identified forms. Selenium combines forms of differing quality, while other preparations remain uncertain.

Ingredient Transparency73

All listed amounts and most forms are stated. Nine mixtures lack a component breakdown, so the amount from each form remains unclear.

Value For Money52

B6, riboflavin, iodine and several trace minerals offer favorable value. Other ingredients offer moderate or less competitive value, and uncertainty about several preparations limits the whole-formula comparison.

Customer Satisfaction92

Customers are generally satisfied with their purchases. The substantial number of ratings makes that feedback more representative, without showing whether the supplement works.

Product Focus19

The clearest role is filling nutrient gaps across normal metabolic and immune functions. The broad ingredient list and many possible uses make it less focused on a single need.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.35
Customer rating
4.7 · 95,085 ratings
Report analysis

Goals

Immunity
Impact
High effect
D+ Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 100 mgVitamin C · 470 mgZinc · 25 mgVitamin A · 1500 mcg RAEVitamin D · 50 mcgSelenium · 200 mcg

Zinc, selenium and relevant vitamins contribute to normal immune function, while B vitamins and folate can help correct low intakes that impair immune-cell function. Vitamin A can contribute to normal protective barriers when its nutrient activity is established. These nutritional roles do not establish fewer infections in adults whose needs are already met. Amount and source limitations constrain some ingredients' contributions.

How this product is rated for Immunity

Ingredient fit53

Relevant ingredients support immune-related roles, while additional actives broaden the formula beyond those contributions.
Goal fit
Relevant ingredients support immune-related roles, while additional actives broaden the formula beyond those contributions.
Dose adequacy
Recognized amounts make partial contributions, and some usable amounts remain limited or unresolved.

Pathways100

Barrier functions, lymphocyte-related functions and oxidative balance reach the saved threshold; innate-cell coverage is smaller.
Depth
The strongest recognized area is oxidative and inflammatory balance; this describes the saved functional finding rather than observed infection protection.
Breadth
Barrier functions, lymphocyte-related functions and oxidative balance reach the saved threshold; innate-cell coverage is smaller.

Evidence100

Zinc drives the strongest saved evidence finding, within the supplied limits on normal immune function and respiratory outcomes.
Evidence strength
Zinc drives the strongest saved evidence finding, within the supplied limits on normal immune function and respiratory outcomes.
Studied preparation
The saved result recognizes the preparations meeting its amount threshold; this does not establish superiority of particular nutrient forms.

Formulation logic100

No configured ingredient conflict was triggered; this covers only the evaluated combinations. All recognized ingredients meet the saved minimum amount threshold; this does not establish a clinical response.
Partner coverage
Recognized ingredients work independently or have their required partners; no extra combination benefit is established.
Conflicts
No configured ingredient conflict was triggered; this covers only the evaluated combinations.
Effective doses
All recognized ingredients meet the saved minimum amount threshold; this does not establish a clinical response.
Study evidence
Magnesium Supportive 8 studies
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
Impact
Highest effect
C+ Ingredient FitA+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 680 mcg DFEVitamin B12 · 300 mcgVitamin D · 50 mcgMagnesium · 100 mgBoron · 3 mgSelenium · 200 mcgZinc · 25 mgVitamin C · 470 mg

Magnesium supplies a nutrient contribution to energy and mineral metabolism when dietary intake falls short. Folate and the accompanying B vitamins contribute nutrients involved in normal metabolism and blood formation. Iodine supports thyroid function when intake is inadequate. These nutritional roles do not establish improved health outcomes when intake is already adequate.

How this product is rated for Everyday Health

Ingredient fit70

Vitamin B9 (Folate) provides a meaningful nutritional connection, with amounts interpreted against the supplied intake comparisons.
Goal fit
Relevant nutrients share the formula with ingredients outside this goal, reducing its specific focus.
Dose adequacy
The counted amounts provide partial coverage of the saved reference ranges; these are nutritional comparisons, not proven clinical response thresholds.

Pathways100

The main recorded connection is energy metabolism cofactors. Nutrient coverage does not establish extra benefit in adequately nourished adults.
Depth
The strongest recorded coverage concerns energy metabolism cofactors, reflecting nutrient availability rather than a proven improvement in symptoms.
Breadth
Coverage extends to energy metabolism cofactors, one-carbon metabolism and blood formation, bone and mineral metabolism, antioxidant and immune defence.

Evidence82

Vitamin B9 (Folate) anchors the saved finding. Its nutritional role is more established than a broad improvement in health outcomes.
Evidence strength
Vitamin B9 (Folate) leads this finding; its support concerns nutritional availability rather than assured benefit above adequate intake.
Studied preparation
The counted preparations meet the saved comparison criteria, without an established benefit from a particular nutrient form or delivery method.

Formulation logic100

The counted nutrients meet the saved partner conditions, and no evaluated formulation concern is triggered.
Partner coverage
The counted nutrients work independently or meet the saved partner conditions; extra combination benefit is not established.
Conflicts
The supplied ingredients and amounts do not trigger the evaluated formulation concerns.
Effective doses
All counted ingredients meet the saved minimum amount criterion, which is distinct from a proven health-outcome dose.
Study evidence
Boron Supportive 6 studies
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Zinc Supportive 60 studies
Impact
Moderate effect
D- Ingredient FitD+ PathwaysA EvidenceA+ Formulation Logic
Magnesium · 100 mgZinc · 25 mgVitamin D · 50 mcgBoron · 3 mg

Zinc may help restore testosterone when low zinc is the cause of reduced levels. Taking extra zinc when you already get enough is not known to raise testosterone.

How this product is rated for Testosterone Support

Ingredient fit42

Zinc is useful for this goal mainly when deficiency is lowering testosterone. Other ingredients do not imply an added hormone benefit.
Goal fit
Zinc has a connection to testosterone, while the broader ingredient mix serves other purposes too.
Dose adequacy
Zinc supplies 12.5 mg per serving; other amounts vary.

Pathways52

Magnesium is linked to testosterone availability, but a routine increase in circulating testosterone remains uncertain.
Depth
Magnesium is linked to testosterone availability, but a routine increase in circulating testosterone remains uncertain.
Breadth
The ingredient connection mainly concerns testosterone availability; a broad effect across hormone processes cannot be assumed.

Evidence91

Zinc can help when deficiency lowers testosterone; it is not known to raise levels above nutritional adequacy.
Evidence strength
Zinc can help when deficiency lowers testosterone; it is not known to raise levels above nutritional adequacy.
Studied preparation
The preparations of Vitamin B6 have an uncertain match to the hormone information; the other relevant preparations have a closer match.

Formulation logic100

No particular conflict or missing required partner is identified among these ingredients.
Partner coverage
No missing required ingredient partner is identified.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The declared serving amounts allow comparison, but do not show that testosterone will increase.
Study evidence
Boron Disputed 3 studies
Magnesium Disputed 5 studies
Selenium No effect 16 studies
Vitamin D Supportive 56 studies
Vitamin E Disputed 3 studies
Zinc Disputed 7 studies
Impact
Moderate effect
C- Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
Iodine · 150 mcgVitamin D · 50 mcgVitamin B5 · 50 mgMagnesium · 100 mgRiboflavin · 50 mgThiamin · 75 mgVitamin B12 · 300 mcg

B vitamins, folate and vitamin C support normal energy metabolism and may help with tiredness when nutrient intake is inadequate. Vitamin D and magnesium add nutritional support, while iodine contributes to thyroid function. Larger B-vitamin amounts do not imply more energy once needs are met.

How this product is rated for Energy

Ingredient fit59

Relevant energy-support nutrients sit within a formula with several other purposes. The relevant amounts provide partial overall dose support.
Goal fit
Relevant energy-support nutrients sit within a formula with several other purposes.
Dose adequacy
The relevant amounts provide partial overall dose support.

Pathways0

The saved findings mainly reflect nutritional support, without measurable coverage of the assessed direct energy mechanisms.
Depth
The saved findings mainly reflect nutritional support, without measurable coverage of the assessed direct energy mechanisms.
Breadth
No combination of assessed direct energy mechanisms reaches broad support in the saved findings.

Evidence94

Vitamin D is the strongest evidence contributor in the saved findings; nutritional need and the studied population still affect likely benefit. Most counted ingredients match studied preparations; Iodine. has less preparation-specific support.
Evidence strength
Vitamin D is the strongest evidence contributor in the saved findings; nutritional need and the studied population still affect likely benefit.
Studied preparation
Most counted ingredients match studied preparations; Iodine. has less preparation-specific support.

Formulation logic100

No missing required partner or assessed ingredient conflict was identified. All counted ingredients pass the saved minimum amount check, although the strength of their contributions differs.
Partner coverage
No required supporting partner is missing for the counted ingredients.
Conflicts
No assessed ingredient conflict was identified.
Effective doses
All counted ingredients pass the saved minimum amount check, although the strength of their contributions differs.
Study evidence
Iodine Adverse 3 studies
Magnesium Supportive 4 studies
Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies
Impact
Moderate effect
C Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 300 mcgNiacin · 50 mg NEVitamin B12 · 300 mcgRiboflavin · 50 mgThiamin · 75 mgVitamin B5 · 50 mgVitamin B6 · 75 mgVitamin D · 50 mcgZinc · 25 mgMagnesium · 100 mg

B vitamins help your body use energy from food, with thiamin playing a part in normal carbohydrate metabolism. That everyday role doesn't mean taking extra will make you burn more calories when you already get enough. The nutrients here relate mainly to normal metabolic function; a lasting rise in energy expenditure or weight loss remains uncertain.

How this product is rated for Metabolism Support

Ingredient fit63

The B vitamins help normal energy metabolism; extra intake is not known to increase calorie burning.
Goal fit
The B vitamins help normal energy metabolism; extra intake is not known to increase calorie burning.
Dose adequacy
The serving provides Vitamin B12 150 mcg, Alpha-lipoic acid 12.5 mg. These amounts alone don't predict an increase in calorie burning.

Pathways4

The relevant connection is stimulation of energy use, with the size and persistence of any effect uncertain.
Depth
The relevant connection is stimulation of energy use, with the size and persistence of any effect uncertain.
Breadth
The connection is limited to stimulation of energy use, rather than several distinct effects on calorie burning.

Evidence100

The B vitamins help normal energy metabolism; extra intake is not known to increase calorie burning.
Evidence strength
The B vitamins help normal energy metabolism; extra intake is not known to increase calorie burning.
Studied preparation
The declared ingredient forms match the relevant preparation descriptions; this alone does not predict the size of a benefit.

Formulation logic100

No particular ingredient conflict or missing required partner is identified.
Partner coverage
No required companion ingredient is missing for the ingredient roles described here.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The declared serving amounts are available for comparison; that does not make them minimum effective doses for increasing calorie burning.
Study evidence
Biotin Supportive 5 studies
Chromium Supportive 47 studies
Iodine Mixed 17 studies
Magnesium Supportive 61 studies
Niacin Supportive 17 studies
Selenium Mixed 28 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies
Vitamin D Supportive 65 studies
Zinc Supportive 12 studies
Impact
High effect
D+ Ingredient FitD PathwaysA+ EvidenceA+ Formulation Logic
Folate · 680 mcg DFEVitamin B12 · 300 mcgVitamin B6 · 75 mgMolybdenum · 100 mcgSelenium · 200 mcgMagnesium · 100 mgVitamin E · 20 mgZinc · 25 mgVitamin C · 470 mgRiboflavin · 50 mg

Folate supports methyl-group metabolism; low folate can impair elimination of arsenic in exposed adults, but the supplied findings do not establish routine toxin removal in adequately nourished people. Selenium has limited mercury-related findings in low-selenium or exposed groups. Normal nutrient and antioxidant functions do not by themselves establish broader detoxification benefits.

How this product is rated for Liver & Detox

Ingredient fit51

The formula includes nutrients counted for this goal alongside many ingredients serving broader purposes. Serving amounts provide differing matches to the supplied reference amounts; these comparisons do not identify proven routine toxin-clearance doses.
Goal fit
The formula includes nutrients counted for this goal alongside many ingredients serving broader purposes.
Dose adequacy
Serving amounts provide differing matches to the supplied reference amounts; these comparisons do not identify proven routine toxin-clearance doses.

Pathways47

The strongest represented area is methyl-group supply, reflecting ingredient roles rather than demonstrated toxin clearance.
Depth
The strongest represented area is methyl-group supply, reflecting ingredient roles rather than demonstrated toxin clearance.
Breadth
The represented coverage includes methyl-group supply. This does not establish removal of unspecified toxins.

Evidence97

Vitamin B9 (Folate) leads the saved evidence comparison; the supplied findings remain limited to their nutritional or disease-specific contexts.
Evidence strength
Vitamin B9 (Folate) leads the saved evidence comparison; the supplied findings remain limited to their nutritional or disease-specific contexts.
Studied preparation
Preparation matching is incomplete for Molybdenum, Vitamin B2 (Riboflavin), Vitamin B6.

Formulation logic100

The counted ingredients meet the saved minimum amount check, which is not evidence of a clinically effective routine detoxification dose.
Partner coverage
No required partner is missing among the counted ingredients; this does not establish added detoxification benefit from their combination.
Conflicts
No configured ingredient conflict was identified from the supplied facts.
Effective doses
The counted ingredients meet the saved minimum amount check, which is not evidence of a clinically effective routine detoxification dose.
Study evidence
Folate Supportive 16 studies
Magnesium Supportive 19 studies
Selenium Supportive 10 studies
Vitamin C Supportive 9 studies
Vitamin E Supportive 23 studies
Zinc Supportive 30 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Beta-Carotene, Vitamin A Acetate)
1500 mcg RAE
Vitamin C (Ascorbic Acid, Calcium Ascorbate, Niacinamide Ascorbate)
470 mg
Vitamin D3 (Cholecalciferol)
50 mcg
Vitamin E (D-Alpha-Tocopherol, D-Alpha-Tocopheryl Succinate)
67 mg
Thiamine (Thiamine Hydrochloride)
75 mg 76
Riboflavin (Riboflavin 5-Phosphate)
50 mg 84
Niacin (Niacinamide, Niacinamide Ascorbate)
50 mg NE
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
75 mg 73
Folate (L-5-Methyltetrahydrofolate)
680 mcg DFE
Vitamin B12 (Methylcobalamin)
300 mcg 67
Biotin
300 mcg 59
Pantothenic Acid (D-Calcium Pantothenate)
50 mg 70
Iodine (Potassium Iodide)
150 mcg 96
Magnesium (Magnesium Oxide)
100 mg
Zinc (L-OptiZinc Zinc Mono-L-Methionine Sulfate, Zinc Citrate)
25 mg 72
Selenium (Se-Methyl L-Selenocysteine, SelenoExcell High Selenium Yeast, Sodium Selenite)
200 mcg 74
Manganese (Manganese Citrate, Manganese Gluconate)
2 mg 82
Chromium (Crominex 3+ Chromium)
200 mcg 61
Molybdenum (Molybdenum Amino Acid Chelate)
100 mcg 70
Inositol
50 mg
Alpha Lipoic Acid
25 mg
natural Mixed Tocopherols (Alpha-Tocopherol, Beta-Tocopherol, Delta Tocopherol, Gamma-Tocopherol)
20 mg
Bio-Quercetin Phytosome
15 mg
Marigold extract
11.12 mg
Apigenin
5 mg 39
Boron (Boron Amino Acid Chelate)
3 mg 63
Lycopene (LycoBeads natural Tomato extract)
1 mg 70
Gluten Free Adults 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
Each serving provides 150 mcg of iodine from potassium iodide, a form the evaluation rates favorably for absorption. A whole-product serving costs about $0.36.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

Potassium iodide is the iodine form used; the evaluation rates it favorably for absorption. The saved data records a non-marine source, so the seaweed-specific sourcing check does not apply.
Iodine Form & Bioavailability
Potassium iodide is the iodine form used; the evaluation rates it favorably for absorption.
Marine Source Purity & Sourcing
The saved data records a non-marine source, so the seaweed-specific sourcing check does not apply.

Dose, Safety & Label Transparency100

Each serving supplies 150 mcg of iodine, an amount the evaluation considers aligned with daily support. The saved facts identify 150 mcg of iodine per serving and potassium iodide as its source.
Dosage Efficacy for Daily Support
Each serving supplies 150 mcg of iodine, an amount the evaluation considers aligned with daily support.
Dosage Safety & Upper Limits
The 150 mcg per serving does not exceed the evaluation’s iodine limit; total intake and individual suitability are not established.
Elemental Iodine Transparency
The saved facts identify 150 mcg of iodine per serving and potassium iodide as its source.

Value80

A whole-product serving costs about $0.36.
Price Per Effective Serving
A whole-product serving costs about $0.36.
C- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value
+1
A serving provides 200 mcg of selenium from a mix of Se-Methyl-L-Selenocysteine, selenium-enriched yeast and sodium selenite. The individual source amounts are unknown, and the whole-product price works out to about $0.36 per 200 mcg of selenium.
How this ingredient is rated

Active Ingredient Quality & Bioavailability55

The selenium comes from three named forms, including an organic L form and an inorganic form, but their individual amounts are unknown.
Selenium Chemical Form
The blend combines organic selenium forms with sodium selenite, an inorganic form; the amount from each source is unknown.
Form Transparency & Isomer Specificity
The forms are named, including a specific L form, but their individual proportions are not disclosed.

Dose, Safety & Label Transparency100

The 200 mcg of selenium per serving matches the amount favored by the evaluation. The evaluation finds that amount leaves a margin for selenium from other sources.
Dosage Efficacy Sweet Spot
The 200 mcg of selenium per serving matches the amount favored by the evaluation.
Safety Margin & UL Adherence
The evaluation finds the 200 mcg serving leaves a margin for selenium from other sources; total intake is unknown.

Value60

The whole-product price is about $0.36 per 200 mcg of selenium.
Price per 200 mcg Serving
The whole-product price works out to about $0.36 per 200 mcg of selenium.
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB Value
Each serving provides 200 mcg of chromium, but its chemical form is unknown. A branded source is recorded, although its name is not available in the saved facts.
How this ingredient is rated

Active Ingredient Quality & Bioavailability30

The chromium form is unknown in the saved facts, although a branded source is recorded.
Chromium Chemical Form
The chromium form is unknown, so its form cannot be assessed.
Branded & Trademarked Sources
A branded chromium source is recorded, but its name is not provided in the saved facts.

Dose, Safety & Label Transparency85

The serving provides 200 mcg of chromium. A separate source-compound weight is unavailable in the saved facts.
Elemental Chromium Dosage
The serving provides 200 mcg of chromium, a substantial amount.
Label Transparency & Disclosure
The saved facts record 200 mcg of chromium per serving; a separate source-compound weight is unavailable.

Value75

The equivalent whole-product cost is about $0.36 per 200 mcg of chromium, based on the recorded serving price and amount.
Price per 200 mcg Chromium
The equivalent whole-product cost is about $0.36 per 200 mcg of chromium, based on the recorded serving price and amount.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  2. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  3. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  4. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  5. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  6. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  7. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsBone Health forFolate
  8. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate Bone Health forVitamin B6
  9. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsBone Health forFolate
  10. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsBone Health forFolate
  11. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  12. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  13. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  14. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  15. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  16. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  17. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  18. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  19. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  20. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese