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2-in-1 Kidney & Liver Super Cleanse

Irwin Naturals
4.5
★ ★ ★ ★ ★
(1339 ratings)
Vitamin B12 250 mcg
Milk Thistle 270 mg
Stinging Nettle 150 mg
European Elder 65 mg
EPA (Eicosapentaenoic Acid) 288 mg
Fish Oil 1600 mg
DHA 192 mg
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Score90

A sophisticated 2-in-1 liver and kidney support formula that includes fish oil and standardized herbal extracts.

How scoring works
Quantity:60 Liquid(s) • (20 servings)
Goals:
Detoxification
Anti-Inflammatory Support
General Health
Energy

Score 90

A sophisticated 2-in-1 liver and kidney support formula that includes fish oil and standardized herbal extracts.

How scoring works
$18.95($0.94 per serving)
Amazon
$ 18.95
iHerb
$ 24.99
Pure Formulas
$ 24.99
Vitacost
$ 24.99
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Analysis

It provides 480mg of combined EPA and DHA, offering a secondary cardiovascular benefit alongside its cleansing goals. The inclusion of BioPerine enhances the absorption of the entire nutrient blend, making the ingredients more effective.

Standardized silymarin and cranberry powder ensure that you are getting reliable levels of active compounds for organ support. This is a very robust, multi-pathway supplement for individuals focused on whole-body maintenance.

Pros

  • Includes standardized silymarin
  • Features BioPerine for better absorption
  • Multi-organ support in one product
  • Provides meaningful fish oil dose
  • Includes NAC for antioxidant support

Cons

  • Complex formula with many ingredients
  • Serving size is multiple liquid softgels
  • Contains soy and beeswax

Warnings

  • Contains uva ursi; not for long-term continuous use
  • Consult a professional if you have kidney disease
  • Take with a full glass of water

Nutrient quality

89 Highest impact

Silymarin is provided at a functional level to support hepatic resilience and antioxidant capacity. While the fish oil provides essential lipids, the specific EPA and DHA concentrations are relatively modest for targeted cardiovascular support.

Ingredient transparency

97 Highest impact

Labeling is thorough, providing specific concentrations for both botanical markers and fish oil fatty acids. The inclusion of the BioPerine complex is clearly noted with its functional amount.

Customer satisfaction

90 Highest impact

A high average rating and a substantial volume of reviews confirm broad user approval for this organ cleanse formula. Feedback suggests that the product reliably meets expectations for metabolic and detoxification support.

Value for money

82 Highest impact

The cost per serving is reasonable given the complexity of the formula and the high quality of the extracts. It offers significant value for individuals seeking a comprehensive, multi-organ support system in one product.

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Goals

Impact
Highest effect
A- Goal FitB+ Strength of SupportB+ CoverageA- Formula Quality

This multi-organ formula utilizes silymarin, N-acetyl cysteine, and barberry to support hepatic and renal detoxification pathways. These ingredients assist in neutralizing environmental metabolites and support the body's natural antioxidant systems.

The liquid softgel format, combined with fish oil, may enhance the absorption of fat-soluble botanical compounds like silymarin. It appears well-suited for patients requiring a comprehensive approach to both liver and kidney clearance support.

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Impact
High effect
B+ Goal FitC+ Strength of SupportA- CoverageA- Formula Quality

Milk Thistle and Nettle extracts combined with Fish Oil provide broad support for metabolic and organ-mediated inflammatory triggers. Standardized Silymarin and individually disclosed EPA/DHA appear well aligned with systemic health goals.

Concentrated herbal extracts ensure that supportive thresholds are met for achieving meaningful physiological balance. The multi-nutrient complex addresses several cellular pathways simultaneously through a diverse array of botanicals.

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Impact
High effect
B+ Goal FitB Strength of SupportA- CoverageB- Formula Quality

Fish Oil provides essential Omega-3 fatty acids to support cardiovascular health and manage systemic inflammation. This broad complex also features several botanical extracts intended for liver and kidney support.

Vitamin B12 as Methylcobalamin contributes to daily energy and nerve health. The formula appears well aligned with general wellness goals, though it addresses many niche detox pathways simultaneously.

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Impact
High effect
B Goal FitB- Strength of SupportC CoverageC+ Formula Quality

Methylcobalamin and various B-vitamins are included in this complex to support metabolic energy and general nutrient status. The formula also provides fish oil to support cellular health and mitochondrial membrane integrity.

While multiple pathways are addressed, the focus on organ cleansing may limit its direct impact on acute energy needs. Several minerals and vitamins are provided at maintenance levels rather than high therapeutic doses.

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Impact
Moderate effect
B- Goal FitD+ Strength of SupportC+ CoverageC+ Formula Quality

Fish oil and milk thistle provision supports cardiovascular health by potentially improving lipid profiles and providing antioxidant protection. This product offers a broad organ-support blend with cardiovascular cross-over benefits.

The 480 mg dose of active EPA and DHA is relatively low for targeted heart support. The formula is complex, and the fish oil concentration is lower than preferred for clinical cardiovascular goals.

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Impact
Moderate effect
B- Goal FitB- Strength of SupportD CoverageC- Formula Quality

The inclusion of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supports brain health by addressing neuroinflammation and structural membrane integrity. These omega-3s appear well aligned with goals for mental clarity and long-term protection.

While the primary goal of this formula is cleanse-oriented, the bioactive methylcobalamin and B6 contribute meaningfully to neurological cofactors. However, the moderate doses of fish oil may be less impactful than concentrated omega-3 supplements for focused cognitive enhancement.

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Impact
Moderate effect
C- Goal FitC- Strength of SupportD+ CoverageD Formula Quality

Methylcobalamin and zinc citrate are included to support red blood cell health and follicle repair. These ingredients are complemented by fish oil and silymarin, which provide broader systemic and antioxidant support.

The 250 mcg dose of B12 and 7.5 mg of zinc are relatively low compared to products specifically targeted for hair health. This cleanse-focused formula contains many botanicals that may not directly contribute to hair thickness or shedding reduction.

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Ingredients

IngredientAmount per serving
Calories
30 Calorie(s)
Total Fat
2 Gram(s)
Saturated Fat
0.5 Gram(s)
Cholesterol
15 mg
Total Carbohydrates
3 Gram(s)
Protein
1 Gram(s)
Vitamin C
50 mg
Vitamin D
4 mcg
Vitamin B6
15 mg
Vitamin B12
250 mcg
Magnesium
12.5 mg
Zinc
7.5 mg
Selenium
50 mcg
Potassium
25 mg
Fish Oil
1600 mg
Eicosapentaenoic Acid
288 mg
Docosahexaenoic Acid
192 mg
Milk Thistle seed extract
270 mg
Silymarin
121.5 mg
Pacran SP Cranberry (Vaccinium macrocarpon) powder
250 mg
Artichoke leaf extract
187.5 mg
Stinging Nettle leaf extract
150 mg
Barberry Root Extract
100 mg
Corn Silk extract
100 mg
European Elder fruit extract
65 mg
Dandelion Leaf Extract
50 mg
Uva Ursi leaf extract
50 mg
N-Acetyl-Cysteine
45 mg
Reishi Mushroom Fruiting Body Extract
15 mg
BioPerine Complex
3 mg
Bioperine
0 NP
Ginger Rhizome Extract
0 NP
Adults 18–50 Women
Report overview
Vitamin B12 · 250 mcg OverallScore62
A- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value
This liver and kidney cleanse supplement includes 250 mcg of B12 as methylcobalamin. While it contains high-quality B12, the dose is only at the maintenance median, reflecting its role as a supportive rather than primary B12 nutrient source.
Milk Thistle · 270 mg OverallScore57
C Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value
This multi-organ cleanse features milk thistle in a liquid form with healthy oils for better absorption. While it is highly transparent, the lower standardization level and high price point reduce its overall score.
Stinging Nettle · 150 mg OverallScore54
D+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
This liver and kidney cleanse uses the correct stinging nettle leaf extract for its intended diuretic goals. It provides a moderate dose, though it is a relatively expensive option.
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