Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
Patel MN; Maheshvari J; Patel N · Cureus · 2025
Randomized trial105 participantsflagHair Health flagNail Health forscienceBiotin
- The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
Narrative reviewflagHair Health forscienceBiotin
- Vitamins A, B, C, and D: A Short Review for the Dermatologist.
Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
Narrative reviewflagHair Health forscienceBiotin
- Biotin for the treatment of nail disease: what is the evidence?
Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
Narrative reviewflagNail Health forscienceBiotin
- Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
Other32 participantsflagNail Health forscienceBiotin
- Brittle nails: response to daily biotin supplementation.
Hochman LG; Scher RK; Meyerson MS · Cutis · 1993
Case series35 participantsflagNail Health forscienceBiotin
- Vitamins and minerals: their role in nail health and disease.
Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
Narrative reviewflagNail Health forscienceBiotin flagNail Health forscienceIron flagNail Health forscienceZinc
- Nail Supplements: When, How, and Why?
Zaraa I; Richert B · Skin appendage disorders · 2026
Narrative reviewflagNail Health forscienceBiotin
- Brittle nails.
Iorizzo M; Pazzaglia M; M Piraccini B; Tullo S; Tosti A · Journal of cosmetic dermatology · 2009
Narrative reviewflagNail Health forscienceBiotin
- Selenium and the course of mild Graves' orbitopathy.
Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
Randomized trial159 participantsflagAnti-Inflammatory Support forscienceSelenium
- Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
Randomized trial70 participantsflagAnti-Inflammatory Support forscienceSelenium
- Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
Randomized trial60 participantsflagAnti-Inflammatory Support forscienceSelenium
- The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
Meta-analysis656 participants11 studies pooledflagAnti-Inflammatory Support forscienceSelenium
- Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
Randomized trial33 participantsflagAnti-Inflammatory Support forscienceSelenium
- Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
Randomized trial107 participantsflagAnti-Inflammatory Support forscienceVitamin C
- The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
Meta-analysis1,162 participants10 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
Meta-analysis852 participants8 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
Systematic review811 participants17 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
Randomized trial44 participantsflagAnti-Inflammatory Support forscienceVitamin C
- Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
Zhou A; Hyppönen E · International journal of epidemiology · 2023
Observational study294,970 participantsflagAnti-Inflammatory Support forscienceVitamin D
- Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
Randomized trial120 participantsflagAnti-Inflammatory Support forscienceVitamin D
- Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
Randomized trial120 participantsflagAnti-Inflammatory Support forscienceVitamin D
- Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
Cross-sectional study9,809 participantsflagAnti-Inflammatory Support forscienceVitamin D
- Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
Cohort study3,072 participantsflagAnti-Inflammatory Support forscienceVitamin D
- Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
Randomized trial110 participantsflagAnti-Inflammatory Support forscienceVitamin E
- Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
Meta-analysis495 participants12 studies pooledflagAnti-Inflammatory Support forscienceVitamin E
- Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
Meta-analysis46 studies pooledflagAnti-Inflammatory Support forscienceVitamin E
- Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
Meta-analysis8 studies pooledflagAnti-Inflammatory Support forscienceVitamin E
- Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
Randomized trial71 participantsflagAnti-Inflammatory Support forscienceVitamin E
- Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
Randomized trial40 participantsflagAnti-Inflammatory Support forscienceZinc
- Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
Meta-analysis23 studies pooledflagAnti-Inflammatory Support forscienceZinc
- The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
Meta-analysis73 studies pooledflagAnti-Inflammatory Support forscienceZinc
- The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
Randomized trial46 participantsflagAnti-Inflammatory Support forscienceZinc
- Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
Meta-analysis75 studies pooledflagAnti-Inflammatory Support forscienceZinc
- Human molybdenum exposure risk in industrial regions of China: New critical effect indicators and reference dose.
Kuang HX; Li MY; Zeng XW; Chen D; Zhou Y; Zheng T; Xiang MD; Wu QZ; Chen XC; Dong GH; Yu YJ · Ecotoxicology and environmental safety · 2024
Cross-sectional study2,267 participantsflagDetoxification forscienceMolybdenum
- Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
Randomized trialflagDetoxification forscienceSelenium
- [Selenium and oxidative stress in cancer patients].
Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
Single-arm trial40 participantsflagDetoxification forscienceSelenium
- Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
Other40 participantsflagDetoxification forscienceSelenium
- Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
Cross-sectional study9,445 participantsflagDetoxification forscienceSelenium
- Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
Randomized trial35 participantsflagDetoxification forscienceSelenium
- Vitamin C supplementation ameliorates liver function profile and antiviral treatment response in Hepatitis C patients.
Nayila I; Javed MS; Khan MA; Hussain G; Raza Naqvi SA; Ali S; Jabeen Z; Shahnawaz S; Akram R; Iman T; Hassan Dogar MZ; Malik SA · Pakistan journal of pharmaceutical sciences · 2022
Non-randomized trial200 participantsflagDetoxification forscienceVitamin C
- Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress.
Alleva R; Di Donato F; Strafella E; Staffolani S; Nocchi L; Borghi B; Pignotti E; Santarelli L; Tomasetti M · The British journal of nutrition · 2012
Non-randomized trial46 participantsflagDetoxification forscienceVitamin C
- Dietary Vitamin C Intake Is Associated With Improved Liver Function and Glucose Metabolism in Chinese Adults.
Luo X; Zhang W; He Z; Yang H; Gao J; Wu P; Ma ZF · Frontiers in nutrition · 2022
Observational study8,307 participantsflagDetoxification forscienceVitamin C
- Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection.
Trepanier LA; Yoder AR; Bajad S; Beckwith MD; Bellehumeur JL; Graziano FM · Journal of acquired immune deficiency syndromes (1999) · 2005
Observational studyflagDetoxification forscienceVitamin C
- Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso.
Lavergne SN; Kurian JR; Bajad SU; Maki JE; Yoder AR; Guzinski MV; Graziano FM; Trepanier LA · Toxicology · 2006
Clinical trial53 participantsflagDetoxification forscienceVitamin C
- Systematic review with meta-analysis: The effect of vitamin E supplementation in adult patients with non-alcoholic fatty liver disease.
Vadarlis A; Antza C; Bakaloudi DR; Doundoulakis I; Kalopitas G; Samara M; Dardavessis T; Maris T; Chourdakis M · Journal of gastroenterology and hepatology · 2021
Meta-analysis8 studies pooledflagDetoxification forscienceVitamin E
- Effect of vitamin E on cardiometabolic factors in paediatric metabolic dysfunction-associated steatotic liver disease: a systematic review with meta-analysis.
Pam P; Musazadeh V; Mahmoudinezhad M; Panahiyan P; Mansoori MA; Zarrin R; Faghfouri AH · The British journal of nutrition · 2026
Meta-analysis665 participants11 studies pooledflagDetoxification forscienceVitamin E
- Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial.
Anushiravani A; Haddadi N; Pourfarmanbar M; Mohammadkarimi V · European journal of gastroenterology & hepatology · 2019
Randomized trial150 participantsflagDetoxification forscienceVitamin E
- Vitamin E administration reduces liver enzyme levels in patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD): evidence from a systematic review and meta-analysis.
Karimi M; Abidi M; Gholamian R; Ostovan A; Zakerolhosseini N; Boroomand S; Esmaeili S; Pourramezan MH; Mohebi S; Javadimoghadam A; Behmaneshnia F; Asbaghi O · Nutrition & metabolism · 2026
Meta-analysis16 studies pooledflagDetoxification forscienceVitamin E
- Haptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis.
Banini BA; Cazanave SC; Yates KP; Asgharpour A; Vincent R; Mirshahi F; Le P; Contos MJ; Tonascia J; Chalasani NP; Kowdley KV; McCullough AJ; Behling CA; Schwimmer JB; Lavine JE; Sanyal AJ; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) · Journal of clinical gastroenterology · 2020
Randomized trial228 participantsflagDetoxification forscienceVitamin E
- Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
Randomized trial80 participantsflagEnergy forscienceMagnesium
- Total magnesium intake and risk of frailty in older women.
Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
Cohort study81,524 participantsflagEnergy forscienceMagnesium
- Red blood cell magnesium and chronic fatigue syndrome.
Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
Randomized trial32 participantsflagEnergy forscienceMagnesium
- Exercise, magnesium and immune function.
Laires MJ; Monteiro C · Magnesium research · 2008
Narrative reviewflagEnergy forscienceMagnesium
- Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
Randomized trial80 participantsflagEnergy forscienceThiamin
- Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
Randomized trial40 participantsflagEnergy forscienceThiamin
- Dietary reference values for thiamin.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagEnergy forscienceThiamin
- Effects of thiamine supplementation on exercise-induced fatigue.
Suzuki M; Itokawa Y · Metabolic brain disease · 1996
Randomized trial16 participantsflagEnergy forscienceThiamin
- Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
Randomized trialflagEnergy forscienceThiamin
- Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
Cohort study55,569 participantsflagGeneral Health forscienceFolate
- The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
Randomized trial119 participantsflagGeneral Health forscienceFolate
- Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
Song S; Song BM; Park HY · The Journal of nutrition · 2023
Cohort study21,260 participantsflagGeneral Health forscienceFolate
- The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
Seyoum Tola F · Medicine · 2024
Systematic reviewflagGeneral Health forscienceFolate
- Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
Systematic review71,847 participants46 studies pooledflagGeneral Health forscienceFolate
- Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
Meta-analysis1,257 participants20 studies pooledflagGeneral Health forscienceMagnesium
- Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
Woods KL; Fletcher S · Lancet (London, England) · 1994
Randomized trial2,316 participantsflagGeneral Health forscienceMagnesium
- Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
Cohort study10,999 participantsflagGeneral Health forscienceMagnesium
- Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
Cohort study9,359 participantsflagGeneral Health forscienceMagnesium
- The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
Randomized trial64 participantsflagGeneral Health forscienceMagnesium
- Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
Meta-analysis95 participants20 studies pooledflagGeneral Health forscienceSelenium
- Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
Meta-analysis507,251 participants41 studies pooledflagGeneral Health forscienceSelenium
- The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
Meta-analysis4 studies pooledflagGeneral Health flagVision Support forscienceSelenium
- Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
Cohort study6,155 participantsflagGeneral Health forscienceSelenium
- Updates on clinical studies of selenium supplementation in radiotherapy.
Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
Systematic review16 studies pooledflagGeneral Health forscienceSelenium
- Vitamin D supplementation for prevention of mortality in adults.
Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
Meta-analysis95,286 participants159 studies pooledflagGeneral Health forscienceVitamin D
- Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
Randomized trial90 participantsflagGeneral Health forscienceVitamin D
- The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
Meta-analysis2,495 participants19 studies pooledflagGeneral Health forscienceVitamin D
- Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
Systematic review84 studies pooledflagGeneral Health forscienceVitamin D
- Meta-analysis of long-term vitamin D supplementation on overall mortality.
Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
Meta-analysis42 studies pooledflagGeneral Health forscienceVitamin D
- Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
Cohort study7,857 participantsflagGeneral Health forscienceVitamin K
- Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
Meta-analysis3,891 participants3 studies pooledflagGeneral Health forscienceVitamin K
- The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
Randomized trial49 participantsflagGeneral Health forscienceVitamin K
- Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
Meta-analysis7 studies pooledflagGeneral Health forscienceVitamin K
- Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
Cohort study1,436 participantsflagGeneral Health forscienceVitamin K
- Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
Randomized trial144 participantsflagGeneral Health forscienceZinc
- Zinc supplementation in young children with acute diarrhea in India.
Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
Randomized trial937 participantsflagGeneral Health forscienceZinc
- Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
Randomized trial4,753 participantsflagGeneral Health forscienceZinc
- Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
Randomized trial84 participantsflagGeneral Health forscienceZinc
- Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
Randomized trial142 participantsflagGeneral Health forscienceZinc
- Menkes disease and response to copper histidine: An Indian case series.
Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
Case series4 participantsflagHair Health forscienceCopper
- Trace element levels in alopecia areata.
Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
Case-control study100 participantsflagHair Health forscienceCopper
- UV damage to hair and the effect of antioxidants and metal chelators.
Millington KR; Marsh JM · International journal of cosmetic science · 2021
In vitro / ex vivo studyflagHair Health forscienceCopper
- Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
In vitro / ex vivo studyflagHair Health forscienceCopper
- Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
Meta-analysis2,538 participants18 studies pooledflagHair Health forscienceFolate
- Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
Case-control study200 participantsflagHair Health forscienceFolate
- Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
Randomized trialflagHair Health forscienceFolate
- Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
Randomized trialflagHair Health forscienceFolate
- Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
Randomized trialflagHair Health forscienceFolate
- The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
Case-control study100,203 participantsflagHair Health forscienceIron
- Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
Meta-analysis10,029 participants36 studies pooledflagHair Health forscienceIron
- Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
Cohort study261 participantsflagHair Health forscienceIron
- Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
Cross-sectional study100 participantsflagHair Health forscienceIron
- Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
Cohort study155 participantsflagHair Health forscienceIron
- Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
Randomized trial87 participantsflagHair Health forscienceSelenium
- Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
Observational study1,407 participantsflagHair Health forscienceSelenium
- A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
Randomized trial64 participantsflagHair Health forscienceSelenium
- Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
Meta-analysis764 participantsflagHair Health forscienceSelenium
- Scientific opinion on the tolerable upper intake level for selenium.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
Systematic reviewflagHair Health forscienceSelenium
- Topical tretinoin for hair growth promotion.
Bazzano GS; Terezakis N; Galen W · Journal of the American Academy of Dermatology · 1986
Non-randomized trial56 participantsflagHair Health forscienceVitamin A
- A review of isotretinoin in the treatment of frontal fibrosing alopecia.
Shahpar A; Nezhad NZ; Sahaf AS; Ahramiyanpour N · Journal of cosmetic dermatology · 2024
Systematic review232 participants15 studies pooledflagHair Health forscienceVitamin A
- Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases.
Rakowska A; Gradzińska A; Olszewska M; Rudnicka L · Journal of drugs in dermatology : JDD · 2018
Cohort study54 participantsflagHair Health forscienceVitamin A
- Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients.
Willaert M; Van Dongen T; Dikrama P; Nijsten T; Hijnen D; Waalboer-Spuij R · Acta dermato-venereologica · 2025
Cohort study315 participantsflagHair Health forscienceVitamin A
- Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes.
Sharma A; Goren A; Dhurat R; Agrawal S; Sinclair R; Trüeb RM; Vañó-Galván S; Chen G; Tan Y; Kovacevic M; Situm M; McCoy J · Dermatologic therapy · 2020
Single-arm trialflagHair Health forscienceVitamin A
- Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
Meta-analysis2,039 participants14 studies pooledflagHair Health forscienceVitamin D
- Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
Randomized trial60 participantsflagHair Health forscienceVitamin D
- Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
Meta-analysisflagHair Health forscienceVitamin D
- Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial.
El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
Randomized trial60 participantsflagHair Health forscienceVitamin D
- Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
Meta-analysis10,670 participants23 studies pooledflagHair Health forscienceVitamin D
- Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
Randomized trial119 participantsflagImmunity forscienceSelenium
- Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
Randomized trial62 participantsflagImmunity forscienceSelenium
- Chemoprevention trial of human hepatitis with selenium supplementation in China.
Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
Non-randomized trial20,847 participantsflagImmunity forscienceSelenium
- Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
Randomized trial70 participantsflagImmunity forscienceSelenium
- Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
Randomized trial70 participantsflagImmunity forscienceSelenium
- Depressed immune response to tetanus in children with vitamin A deficiency.
Semba RD; Muhilal; Scott AL; Natadisastra G; Wirasasmita S; Mele L; Ridwan E; West KP; Sommer A · The Journal of nutrition · 1992
Randomized trial236 participantsflagImmunity forscienceVitamin A
- Impact of a single megadose of vitamin A at delivery on breastmilk of mothers and morbidity of their infants.
Roy SK; Islam A; Molla A; Akramuzzaman SM; Jahan F; Fuchs G · European journal of clinical nutrition · 1997
Randomized trial50 participantsflagImmunity forscienceVitamin A
- Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial.
Coutsoudis A; Broughton M; Coovadia HM · The American journal of clinical nutrition · 1991
Randomized trial60 participantsflagImmunity forscienceVitamin A
- Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles.
Coutsoudis A; Kiepiela P; Coovadia HM; Broughton M · The Pediatric infectious disease journal · 1992
Randomized trial60 participantsflagImmunity forscienceVitamin A
- Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
Long KZ; Santos JI; Estrada Garcia T; Haas M; Firestone M; Bhagwat J; Dupont HL; Hertzmark E; Rosado JL; Nanthakumar NN · The Journal of nutrition · 2006
Randomized trial127 participantsflagImmunity forscienceVitamin A
- Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagImmunity forscienceVitamin C
- Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
Meta-analysis2,334 participants14 studies pooledflagImmunity forscienceVitamin C
- Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
Meta-analysisflagImmunity forscienceVitamin C
- New evidence for antioxidant properties of vitamin C.
Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
Randomized trial20 participantsflagImmunity forscienceVitamin C
- Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
Calder PC; Kreider RB; McKay DL · Nutrients · 2025
Systematic review13 studies pooledflagImmunity forscienceVitamin C
- Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
Meta-analysis11,321 participants25 studies pooledflagImmunity forscienceVitamin D
- Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
Meta-analysis4,859 participants10 studies pooledflagImmunity forscienceVitamin D
- Vitamin D3 and deconvoluting a rash.
Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
Randomized trial28 participantsflagImmunity forscienceVitamin D
- Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
Randomized trial110 participantsflagImmunity forscienceVitamin D
- Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
Meta-analysis50,554 participants65 studies pooledflagImmunity forscienceVitamin D
- Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
Meta-analysis199,055 participants115 studies pooledflagImmunity forscienceZinc
- Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
Randomized trial609 participantsflagImmunity forscienceZinc
- A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
Randomized trial64 participantsflagImmunity forscienceZinc
- The effect of zinc and vitamin A supplementation on immune response in an older population.
Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
Randomized trial136 participantsflagImmunity forscienceZinc
- The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
Systematic review13 studies pooledflagImmunity forscienceZinc
- Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
Randomized trial50 participantsflagNail Health forscienceBiotin
- A pilot iron substitution programme in female blood donors with iron deficiency without anaemia.
Pittori C; Buser A; Gasser UE; Sigle J; Job S; Rüesch M; Tichelli A; Infanti L · Vox sanguinis · 2011
Non-randomized trial224 participantsflagNail Health forscienceIron
- Evaluation of nail abnormalities.
Tully AS; Trayes KP; Studdiford JS · American family physician · 2013
Narrative reviewflagNail Health forscienceIron
- Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial
Adele Sparavigna, Beatrice Tenconi, Laura La Penna · Clinical, Cosmetic and Investigational Dermatology · 2019
Randomized trial48 participantsflagNail Health forscienceIron
- Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
Other20 participantsflagNail Health forscienceVitamin C
- Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
Randomized trialflagSkin Health forscienceCopper
- Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
Randomized trial57 participantsflagSkin Health forscienceCopper
- Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
Animal experimentflagSkin Health forscienceCopper
- Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
Animal experimentflagSkin Health forscienceCopper
- Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
Single-arm trialflagSkin Health forscienceCopper
- The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
Randomized trial138 participantsflagSkin Health forscienceNiacin
- Niacinamide: A B vitamin that improves aging facial skin appearance.
Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
Randomized trial50 participantsflagSkin Health forscienceNiacin
- The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
Randomized trial52 participantsflagSkin Health forscienceNiacin
- A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
Randomized trial386 participantsflagSkin Health forscienceNiacin
- Nicotinamide for Skin Cancer Chemoprevention.
Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
Cohort study33,822 participantsflagSkin Health forscienceNiacin
- Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
Chu AC · Dermatologica · 1985
Randomized trial38 participantsflagSkin Health forscienceSelenium
- Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
Randomized trial1,312 participantsflagSkin Health forscienceSelenium
- Evidence-Based Nutritional Interventions in Wound Care.
Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
Systematic review2,339 participants36 studies pooledflagSkin Health forscienceSelenium flagSkin Health forscienceVitamin E
- A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
Randomized trial121 participantsflagSkin Health forscienceSelenium
- The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
Clinical trial31 participantsflagSkin Health forscienceSelenium
- Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
Meta-analysis471 participants6 studies pooledflagSkin Health forscienceVitamin A
- Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
Randomized trial120 participantsflagSkin Health forscienceVitamin A
- Antiaging action of retinol: from molecular to clinical.
Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
Randomized trial48 participantsflagSkin Health forscienceVitamin A
- An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
Narrative reviewflagSkin Health forscienceVitamin A
- Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
Randomized trialflagSkin Health forscienceVitamin A
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C
- Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
Randomized trial45 participantsflagSkin Health forscienceVitamin E
- Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
Meta-analysis20 studies pooledflagSkin Health forscienceVitamin E
- Effects of tocotrienol on aging skin: A systematic review.
Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
Systematic reviewflagSkin Health forscienceVitamin E
- Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
Randomized trialflagSkin Health forscienceVitamin E
- What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
Systematic review27 studies pooledflagVision Support forscienceCopper
- Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E; Mares J; Clemons TE; Swaroop A; Chew EY; Keenan TDL; AREDS and AREDS2 Research Groups · Ophthalmology · 2021
Cohort study8,242 participantsflagVision Support forscienceCopper
- Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational study.
Lu Y; Li C; Liu Y; Wu T; Lu P · BMC ophthalmology · 2025
Observational study4,996 participantsflagVision Support forscienceCopper
- Associations between dietary nutrient intake and the risk of multiple age-related ocular diseases: evidence from longitudinal analysis.
Yang Y; Zou H · The journal of nutrition, health & aging · 2026
Cohort study103,192 participantsflagVision Support forscienceCopper
- Dietary habits and dietary nutrient intake in patients with age-related macular degeneration: A case-control study.
Šalková Kráľová J; Kolář P; Kapounová Z; Veselý P; Derflerová Brázdová Z · Central European journal of public health · 2023
Case-control study151 participantsflagVision Support forscienceCopper
- Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial.
Watson SL; Jones LW; Stapleton F; Hinds M; Ng A; Tan J; Alster Y; Bosworth C; Rafaeli O; DePuy V; CELESTIAL STUDY Group · The ocular surface · 2026
Randomized trial245 participantsflagVision Support forscienceSelenium
- Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial.
Downie LE; Craig JP; Stapleton F; Tan J; Jones LW; Ng A; Hinds M; Bosworth C; Alster Y · The ocular surface · 2025
Randomized trial245 participantsflagVision Support forscienceSelenium
- AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
Stapleton F; Hinds M; Tan J; Jones L; Chalmers R; Bosworth C; Alster Y · The ocular surface · 2025
Randomized trial67 participantsflagVision Support forscienceSelenium
- The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study.
Stapleton F; Jia T; DePuy V; Bosworth C; Gleeson M; Tan J · The ocular surface · 2025
Randomized trial14 participantsflagVision Support forscienceSelenium
- A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
Randomized trial601 participantsflagVision Support forscienceVitamin A
- Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
Randomized trial66 participantsflagVision Support forscienceVitamin A
- Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
Meta-analysis1,223,856 participants47 studies pooledflagVision Support forscienceVitamin A
- Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
Randomized trial89 participantsflagVision Support forscienceVitamin A
- Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
Randomized trial104 participantsflagVision Support forscienceVitamin A
- Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
Randomized trial400 participantsflagVision Support forscienceVitamin C
- Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
Observational studyflagVision Support forscienceVitamin C
- Nutritional modulation of cataract.
Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
Narrative reviewflagVision Support forscienceVitamin C
- Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
Case-control study530 participantsflagVision Support forscienceVitamin C flagVision Support forscienceVitamin E
- Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; LaÃns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
Case-control study883 participantsflagVision Support forscienceVitamin C
- Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
Meta-analysis55,614 participants4 studies pooledflagVision Support forscienceVitamin E
- Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
Cohort study35,551 participantsflagVision Support forscienceVitamin E
- Long-term nutrient intake and 5-year change in nuclear lens opacities.
Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
Cohort study408 participantsflagVision Support forscienceVitamin E
- Dietary intake of antioxidants and risk of age-related macular degeneration.
van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
Cohort study4,765 participantsflagVision Support forscienceVitamin E
- Antioxidant vitamin and mineral supplements for age-related macular degeneration.
Evans JR · The Cochrane database of systematic reviews · 2002
Systematic review170 participants7 studies pooledflagVision Support forscienceZinc
- Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2023
Meta-analysis3,790 participants5 studies pooledflagVision Support forscienceZinc
- Oral zinc in macular degeneration.
Newsome DA; Swartz M; Leone NC; Elston RC; Miller E · Archives of ophthalmology (Chicago, Ill. : 1960) · 1988
Randomized trial151 participantsflagVision Support forscienceZinc
- A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
Age-Related Eye Disease Study Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
Randomized trial3,640 participantsflagVision Support forscienceZinc
- Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand.
Udomkesmalee E; Dhanamitta S; Sirisinha S; Charoenkiatkul S; Tuntipopipat S; Banjong O; Rojroongwasinkul N; Kramer TR; Smith JC · The American journal of clinical nutrition · 1992
Randomized trial133 participantsflagVision Support forscienceZinc