Product Image

High Potency Vitamin B Complex

Lake Avenue Nutrition
4.5
★ ★ ★ ★ ★
(15687 ratings)
Thiamin 110 mg
Riboflavin 10 mg
Niacin 140 mg
Vitamin B5 110 mg
Vitamin B12 400 mcg
Biotin 500 mcg
Choline 28 mg
Product Image
Score82

A strong activated-form B complex with methylfolate and methylcobalamin. Very high niacin is the main safety and tolerance drawback.

How scoring works
Quantity:30 Capsule(s) • (30 servings)
Goals:
Energy
General Health
Metabolism Boost
Cognitive Support

Score 82

A strong activated-form B complex with methylfolate and methylcobalamin. Very high niacin is the main safety and tolerance drawback.

How scoring works

Also available as

1 option
90 servings 1 Capsule(s) • 90 Capsule(s) • 90 servings $20.23 ($0.22 per serving)
$7.18($0.23 per serving)
iHerb
$ 7.18
iHerb
$ 7.18
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Analysis

The capsule uses methylfolate, methylcobalamin, riboflavin 5-phosphate, and pyridoxal 5-phosphate. High thiamine and pantothenic acid amounts support the high-potency positioning.

Niacin reaches 140 mg across niacinamide and nicotinic acid, while vitamin B6 is supplied at 10 mg. The niacin amount is the dominant tolerance concern, and 28 mg choline provides only modest coverage.

The compact 30-serving package suits users who want to trial an activated B complex. It fits energy and general B-vitamin support better than hair or cognitive goals, where broader ingredients would be needed.

Who is it for
  • Adults seeking activated B-vitamin forms
  • People wanting methylfolate and methylcobalamin
  • Users comfortable with a high-niacin formula
Best for
  • Activated B-complex coverage
  • Normal energy metabolism
  • Methylated folate and B12 intake

Pros

  • Uses methylfolate and methylcobalamin
  • Includes riboflavin 5-phosphate
  • Includes pyridoxal 5-phosphate
  • Focused ingredient list

Cons

  • Very high niacin amount
  • Only modest choline
  • Shorter serving supply
  • Limited broader goal coverage

Warnings

  • The 140 mg niacin amount may cause flushing or digestive discomfort
  • High niacin can be unsuitable for people with glucose-control or liver concerns
  • Do not combine it with another high-dose niacin product without guidance

Nutrient quality

82 Highest impact

Several active coenzyme forms and substantial amounts create strong metabolic coverage. High niacin with an unclear nicotinic-acid share makes tolerability harder to predict.

Ingredient transparency

83 Highest impact

All B vitamins have separate amounts and no proprietary blend hides the core formula. Duplicate entries make the split between niacin forms and some nutrient sources harder to interpret.

Customer satisfaction

77 High impact

The strong average rating is supported by an exceptionally large review base. No review excerpts describe tolerance, effectiveness, or repeated complaints, so those experiences remain uncertain.

Value for money

84 Highest impact

Premium active forms and a focused capsule provide strong value. The short supply and potential niacin flushing reduce convenience compared with the larger version.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageA Formula Quality
Vitamin B5 · 110 mgRiboflavin · 10 mgThiamin · 110 mgVitamin B12 · 400 mcg

High-dose thiamin, methylcobalamin, active folate, riboflavin phosphate, and P5P provide a strong metabolic-energy B complex. B12 exceeds the preferred goal threshold and the active forms improve confidence in use.

The formula remains focused and transparent without proprietary blends. Niacin is high enough to cause flushing in sensitive users because part is supplied as nicotinic acid.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
General Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportB- CoverageA Formula Quality
Folate · 670 mcg DFEVitamin B12 · 400 mcg

Active riboflavin, vitamin B6, folate, and methylcobalamin make this a well-formed B-complex. The focused combination gives meaningful support for energy metabolism and methylation.

It does not cover minerals, vitamin D, essential fats, or other major general-health pillars. The combined niacin amount is high and the label does not show how much comes from flushing nicotinic acid, which limits suitability for unsupervised daily use.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C Goal FitB+ Strength of SupportC- CoverageA- Formula Quality
Biotin · 500 mcgNiacin · 140 mgVitamin B12 · 400 mcgRiboflavin · 10 mgThiamin · 110 mgVitamin B5 · 110 mgVitamin B6 · 10 mg

High-potency B vitamins directly support the enzyme systems that convert food into cellular energy. The formula does not add thyroid nutrients, glucose-control minerals, thermogenic agents, or a dedicated mitochondrial compound.

Active riboflavin, vitamin B6, folate, and vitamin B12 forms strengthen delivery, and all major amounts are clearly disclosed. The focused capsule works well as an energy-cofactor supplement but provides narrow pathway coverage for a broader metabolism goal.

Study evidence
Riboflavin Mixed 5 studies
Vitamin B12 Supportive 10 studies
Vitamin B6 Supportive 16 studies
Cognitive Support
Cognitive Support
Impact
High effect
C- Goal FitB Strength of SupportC CoverageB+ Formula Quality
Choline · 28 mgThiamin · 110 mgVitamin B6 · 10 mgFolate · 670 mcg DFEVitamin B12 · 400 mcg

High thiamin, active B6, methylfolate, methylcobalamin, and other B vitamins provide strong cofactor support for energy and neurotransmitter metabolism. The formula may help cognition when B-vitamin status is low, but its choline amount is too small for direct cholinergic support.

Bioactive forms, clear amounts, and a single capsule create a coherent design. High niacin may cause flushing or stomach upset in sensitive users, while cognitive benefits remain mostly foundational.

Study evidence
Choline Supportive 76 studies
Thiamin Supportive 30 studies
Vitamin B12 Disputed 84 studies
Hair Health
Hair Health
Impact
Moderate effect
C- Goal FitB Strength of SupportD+ CoverageB- Formula Quality
Biotin · 500 mcg

Biotin, methylfolate, methylcobalamin, and other B vitamins can support hair when a deficiency is present. The formula lacks iron, zinc, vitamin D, structural amino acids, or hormonal support.

Bioactive folate and B12 forms improve quality, but biotin remains a moderate maintenance amount. Its hair relevance is narrow and secondary to general B-vitamin supplementation.

Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Thiamine Hydrochloride
110 mg
Riboflavin (Riboflavin 5-Phosphate)
 10 mg
Niacin (Niacinamide, Nicotinic Acid)
 140 mg
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
 10 mg
Folate ((6S)-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
 670 mcg DFE
Vitamin B12 (Methylcobalamin)
 400 mcg
Biotin
500 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 110 mg
Choline (Choline Dihydrogen Citrate)
 28 mg
Inositol
100 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Thiamin · 110 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Thiamine hydrochloride is a clearly identified standard form supplied at a strong high-potency dose. The label makes the amount easy to verify, and the simple capsule format avoids a hidden proprietary blend. Its low serving cost and substantial thiamin amount create excellent value for a B-complex.

View ingredientView products
Riboflavin (Riboflavin 5-Phosphate) · 10 mg OverallScore81
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB+ Value

Riboflavin 5-phosphate is the bioactive coenzyme form and is ready for cellular use. The 10 mg dose provides low maintenance support despite using the active coenzyme form. Value is favorable because the premium phosphate form is offered at a modest serving cost.

View ingredientView products
Niacin (Niacinamide, Nicotinic Acid) · 140 mg OverallScore68
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

The B-complex clearly lists both niacinamide and nicotinic acid, pairing a general-use form with one that may support cardiovascular goals. Standard capsule delivery offers no special release control, but the disclosed amount is substantial. The 140 mg nicotinic acid dose may cause flushing, redness, or tingling, and no flush warning is provided.

View ingredientView products
Loading alternative details
85 Performance

B-Complex Plus

Pure Encapsulations
<p>Methylfolate, methylcobalamin, P-5-P, and activated riboflavin retain active forms with a more restrained vitamin B6 amount. Niacin is still elevated, but the profile is better balanced than the original high-potency blend.</p>
85 Performance

BioCoenzymated Active B Complex

Natural Factors
<p>Active thiamine, riboflavin, vitamin B6, folate, and vitamin B12 provide broad refined coverage. Moderate vitamin B6 and clearer niacin positioning make the formula more balanced than the original ambiguous high-niacin blend.</p>
81 Performance

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Several coenzyme B-vitamin forms offer broad energy and metabolism support with moderate vitamin B6. Mixed methylfolate and folic acid plus small choline are trade-offs, but the dosing is more balanced than the original.</p>
84 Budget

Super B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
<p>A broad B-complex supplies B12, niacin, thiamine, biotin, and riboflavin at a lower serving cost with less aggressive overall dosing. Forms are more basic and high biotin can interfere with laboratory tests, but the profile is gentler for everyday use.</p>
75 Budget

B-Complex

Paradise Earth's Blend
<p>Active thiamine, riboflavin, vitamin B6, folate, and vitamin B12 preserve refined form quality at a lower serving cost. Vitamin B6 remains high and tiny blended extras add little, but the niacin exposure is less ambiguous than in the original.</p>
75 Budget

B-100

NOW
<p>High-potency B vitamins provide inexpensive collection overlap at a lower serving cost. The supplied panel unexpectedly omits vitamin B6 and relies on conventional forms, making it less complete than the original active-form formula.</p>
83 Value

High Potency Vitamin B Complex

Lake Avenue Nutrition
<p>The same active-form formula comes in a longer supply with a lower serving cost. It retains the original uncertainty around flush-producing nicotinic acid, but improves value without changing the core nutrient profile.</p>
79 Value

B Complex Plus

Seeking Health
<p>Active riboflavin, vitamin B6, and vitamin B12 provide a well-designed B-complex with meaningful amounts. Niacin remains ambiguous and could cause flushing, but the profile is less extreme while offering reasonable value.</p>
80 Value

B-Complex '100'

Solgar
<p>Broad B12, niacin, thiamine, vitamin B6, riboflavin, choline, and pantothenic acid coverage comes at a low serving cost. Conventional forms and very high vitamin B6 reduce quality, but the formula offers economical breadth.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  2. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  3. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  4. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  5. Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis.
    Long C; Li Z; Feng H; Jiang Y; Pu Y; Tao J; Yue R · Frontiers in aging neuroscience · 2024
    Meta-analysis82,246 participants9 studies pooledCognitive Support forCholine
  6. Gut microbiota-mediated choline metabolism exacerbates cognitive impairment induced by chronic cerebral hypoperfusion.
    Li X; Ren Y; Gao X; Wang H; Zhang J; Xie J; Liang J; Zhao B; Zhou H; Yin J · Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Cross-sectional studyCognitive Support forCholine
  7. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  8. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  9. Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study.
    Yamashita S; Kawada N; Wang W; Susaki K; Takeda Y; Kimura M; Iwama Y; Miura Y; Sugano M; Matsuoka R · Lipids in health and disease · 2023
    Randomized trial41 participantsCognitive Support forCholine
  10. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  11. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  12. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  13. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  14. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  15. Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.
    Measelle JR; Baldwin DA; Gallant J; Chan K; Green TJ; Wieringa FT; Borath M; Prak S; Hampel D; Shahab-Ferdows S; Allen LH; Kroeun H; Whitfield KC · Annals of the New York Academy of Sciences · 2021
    Randomized trial335 participantsCognitive Support forThiamin
  16. What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? - A systematic review.
    Teixeira J; Pereira I; Castanho M; Simões do Couto F · European journal of internal medicine · 2025
    Systematic reviewCognitive Support forThiamin
  17. Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
    Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
    Cross-sectional study2,422 participantsCognitive Support forThiamin
  18. Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014.
    Ji K; Sun M; Hong Y; Li L; Wang X; Li C; Yang S; Du W; Xu K; Zhou H · Heliyon · 2024
    Cross-sectional study2,896 participantsCognitive Support forThiamin
  19. A systematic review of treatments for alcohol-related cognitive impairment: lessons from the past and gaps for future interventions.
    Caballeria E; Oliveras C; Nuño L; Balcells-Oliveró M; Gual A; López-Pelayo H · Psychological medicine · 2021
    Systematic review26 studies pooledCognitive Support forThiamin
  20. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  21. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  22. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support forVitamin B12
  23. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsCognitive Support forVitamin B12
  24. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support forVitamin B12
  25. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  26. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  27. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  28. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  29. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  30. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  31. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  32. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  33. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  34. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  35. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  36. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  37. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  38. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  39. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  40. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  41. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  42. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  43. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  44. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  45. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  46. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  47. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  48. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  49. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  50. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  51. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  52. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  53. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  54. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  55. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  56. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  57. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  58. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  59. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  60. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
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    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  62. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
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    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  64. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
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    Guideline / consensusMetabolism Boost forVitamin B12
  65. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  66. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
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    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12
  68. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
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    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  70. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
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    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
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    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6