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Magnesium Plus Mixed Berry Flavor

Pure Essence Ionic-Fizz
4.6
★ ★ ★ ★ ★
(985 ratings)
Folate 50 mcg
Potassium 100 mg
Magnesium 300 mg
Product Image
Score79
A useful long-supply magnesium drink with active B vitamins and modest potassium. The carbonate form and tiny botanical additions limit its edge.
How scoring works
Quantity:12 Ounce(s) • (60 servings)
Goals:
Energy
General Health
Heart Health
Bone Health
Sleep Support

Score 79

A useful long-supply magnesium drink with active B vitamins and modest potassium. The carbonate form and tiny botanical additions limit its edge.
How scoring works
$40.58($0.67 per serving)
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$ 40.58
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Analysis

A meaningful magnesium amount supports the product's core role, while vitamin C and active folate and B12 forms add quality. Potassium and trace minerals provide secondary coverage.

The magnesium comes from carbonate rather than a more readily absorbed form such as citrate or glycinate. Beet root and grape-skin extracts are present at token amounts that are unlikely to define the outcome.

The longer supply suits users who enjoy a berry-flavored drink each day. It is best understood as a magnesium powder, not a full solution for sleep, heart health, digestion, fitness, or testosterone.

Who is it for
  • Regular users of flavored magnesium powder
  • Adults wanting a longer mixed-berry supply
  • People focused primarily on magnesium
Best for
  • Daily magnesium routines
  • Muscle and nerve support
  • Drink-based supplementation

Pros

  • Meaningful magnesium amount
  • Includes active folate and B12
  • Long supply with practical value

Cons

  • Uses magnesium carbonate
  • Minimal plant-extract amounts
  • Not targeted enough for its many listed goals

Warnings

  • Magnesium carbonate can cause loose stools, gas, or cramping.
  • Keep the serving away from thyroid medicines and certain antibiotics.
  • Reduced kidney function can increase risk from concentrated magnesium and potassium.

Nutrient quality

79 High impact

A substantial magnesium amount and active folate provide a useful mineral foundation. Magnesium carbonate and several lightly dosed supporting ingredients limit absorption quality and formula depth.

Ingredient transparency

82 Highest impact

All listed actives have separate amounts and no proprietary blend hides the mineral formula. Complete mixing guidance and flavor-system ingredients are not supplied, while several botanical names lack standardization.

Customer satisfaction

75 High impact

The very strong average rating is supported by a useful review base. No review excerpts describe tolerance, ease of use, or repeated complaints, so those experiences remain uncertain.

Value for money

77 High impact

The larger package provides the strongest ongoing value among these flavor variants. The weaker magnesium form and token secondary additions keep quality below the strongest mineral powders.

Report analysis

Goals

Energy
Impact
Highest effect
A- Goal FitA- Strength of SupportB CoverageB- Formula Quality
Vitamin D · 2.5 mcgMagnesium · 300 mgVitamin B12 · 30 mcgPotassium · 100 mg

A substantial magnesium amount and useful vitamin C dose provide the clearest foundational support for muscles, nerves, energy metabolism, and antioxidant defenses. Several B vitamins and trace minerals broaden the drink, although many are modestly dosed.

Most active forms and amounts are transparent, but the botanical and sea-mineral additions add little assessable depth. The 300 mg magnesium serving may cause loose stools or cramping when combined with other magnesium sources.

Study evidence
Magnesium Supportive 4 studies
General Health
Impact
High effect
A Goal FitB- Strength of SupportB CoverageC Formula Quality
Folate · 50 mcgVitamin B12 · 30 mcgVitamin D · 2.5 mcgMagnesium · 300 mgBoron · 500 mcgZinc · 2 mgVitamin C · 250 mg

Magnesium anchors a broad mix of nutrients that may support muscle, nerve, energy, and antioxidant functions. Vitamin C is meaningful, while several other vitamins and minerals are included only in modest amounts.

Magnesium carbonate is less attractive than well-absorbed chelated forms, although active methylfolate and methylcobalamin improve the vitamin profile. The magnesium amount may cause loose stools or stomach upset in sensitive users.

Study evidence
Boron Supportive 6 studies
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Vitamin C Supportive 56 studies
Heart Health
Impact
High effect
B- Goal FitB+ Strength of SupportC+ CoverageC Formula Quality
Magnesium · 300 mgVitamin B12 · 30 mcgVitamin B6 · 1 mgFolate · 50 mcgVitamin D · 2.5 mcg

Magnesium at 300 mg provides meaningful foundational cardiovascular support, while methylated B vitamins may aid homocysteine metabolism. A small beet amount adds only minimal nitric-oxide support.

Magnesium carbonate is clearly disclosed, and methylcobalamin and methylfolate improve B-vitamin form quality. Numerous trace minerals and tiny botanical additions make the formula broader on the label than in functional cardiovascular depth.

Study evidence
Magnesium Supportive 158 studies
Bone Health
Impact
High effect
B Goal FitB- Strength of SupportC+ CoverageC Formula Quality
Magnesium · 300 mgVitamin D · 2.5 mcgCopper · 0.25 mgManganese · 1 mgBoron · 500 mcgZinc · 2 mgVitamin C · 250 mg

Magnesium provides a meaningful mineral contribution to bone formation and vitamin D function. Small amounts of vitamin D3, zinc, copper, manganese, and boron add related support but are not substantial enough to make the formula comprehensive.

The magnesium amount is useful, although magnesium carbonate is less appealing than citrate or a well-defined chelate. Many added vitamins and plant powders broaden the label more than they deepen skeletal support.

Study evidence
Boron Supportive 5 studies
Copper Disputed 20 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Vitamin D Supportive 202 studies
Zinc Supportive 33 studies
Sleep Support
Impact
High effect
B- Goal FitB Strength of SupportC CoverageD Formula Quality
Magnesium · 300 mg

Magnesium may support relaxation and sleep quality when intake is inadequate. The serving provides 300 mg as magnesium carbonate in a broad vitamin-and-mineral drink mix.

Magnesium carbonate is less preferred for bedtime use than glycinate, and the amount may cause digestive discomfort in sensitive users. Numerous vitamins, minerals, and botanical extras add complexity without creating another strong sleep pathway.

Study evidence
Magnesium Supportive 23 studies
Stress Relief
Impact
Moderate effect
B- Goal FitC+ Strength of SupportD+ CoverageC- Formula Quality
Vitamin D · 2.5 mcgMagnesium · 300 mgFolate · 50 mcgVitamin B12 · 30 mcgVitamin B6 · 1 mgVitamin C · 250 mg

Magnesium provides a meaningful foundation for nervous-system regulation, while methylfolate and B vitamins offer light metabolic support. Magnesium carbonate is less compelling than better-absorbed citrate, glycinate, or taurate forms.

Most of the remaining botanicals and trace minerals are too small or too indirect to deepen stress relief. The broad label lacks an adaptogen or a direct calming amino acid.

Study evidence
Folate Supportive 19 studies
Magnesium Supportive 13 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
150 mcg
Vitamin C (Ascorbic Acid)
250 mg
Vitamin D3
2.5 mcg
Vitamin B6 (Pyridoxine Hydrochloride)
1 mg
Folate (L-5-Methyltetrahydrofolate)
50 mcg
Vitamin B12 (Methylcobalamin)
30 mcg
Magnesium (Magnesium Carbonate)
300 mg
Zinc (Zinc Lactate)
2 mg
Copper (Copper Gluconate)
0.25 mg
Manganese (Manganese Gluconate)
1 mg
Potassium (Potassium Bicarbonate)
100 mg
Bamboo extract
60 mg
ionic Sea Minerals
10 mg
Beet root powder
8 mg
Grape skin extract
7 mg
Boron (Boron Citrate)
500 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
A Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyB+ Value

L-5-MTHF provides a body-ready form, while its amount is very low for general folate support. The dose disclosure is clear despite omitting explicit DFE wording, and adequate B12 supports masking-risk safeguards. Cost efficiency is strong for the active folate delivered.

A+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyF Value

The formula uses bioavailable potassium bicarbonate with useful alkalizing properties. Potency remains low, and full elemental-yield disclosure is absent. A moderate serving cost offers only modest value for potassium.

F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Uses low-bioavailability magnesium carbonate at a therapeutic elemental amount. Vitamin B6, vitamin D, or boron adds relevant formulation support. High cost and a primary oxide or carbonate source weaken value.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses.
    Bo Y; Zhu Y; Tao Y; Li X; Zhai D; Bu Y; Wan Z; Wang L; Wang Y; Yu Z · Frontiers in public health · 2021
    Meta-analysis108 studies pooledGeneral Health forFolate
  2. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledGeneral Health forFolate
  3. Association of folate intake with cardiovascular-disease mortality and all-cause mortality among people at high risk of cardiovascular-disease.
    Xu X; Wei W; Jiang W; Song Q; Chen Y; Li Y; Zhao Y; Sun H; Yang X · Clinical nutrition (Edinburgh, Scotland) · 2022
    Cohort study14,234 participantsGeneral Health forFolate
  4. The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review.
    Wang R; Chen C; Liu W; Zhou T; Xun P; He K; Chen P · Magnesium research · 2018
    Meta-analysis542 participants14 studies pooledFitness forMagnesium
  5. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation.
    Setaro L; Santos-Silva PR; Nakano EY; Sales CH; Nunes N; Greve JM; Colli C · Journal of sports sciences · 2014
    Randomized trial25 participantsFitness forMagnesium
  6. Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.
    Bomar MC; Ewell TR; Brown RL; Brown DM; Kwarteng BS; Abbotts KSS; Butterklee HM; Williams NNB; Wrigley SD; Walsh MA; Hamilton KL; Thomson DP; Weir TL; Bell C · Nutrients · 2025
    Randomized trial15 participantsFitness forMagnesium
  7. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  8. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature.
    Arab A; Rafie N; Amani R; Shirani F · Biological trace element research · 2023
    Systematic review7,582 participants9 studies pooledSleep Support forMagnesium
  9. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep.
    Nielsen FH; Johnson LK; Zeng H · Magnesium research · 2011
    Randomized trial100 participantsSleep Support forMagnesium
  10. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledHeart Health Cardiovascular Support forMagnesium
  11. Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial.
    Schutten JC; Joris PJ; Groendijk I; Eelderink C; Groothof D; van der Veen Y; Westerhuis R; Goorman F; Danel RM; de Borst MH; Bakker SJL · Journal of the American Heart Association · 2022
    Randomized trial164 participantsHeart Health forMagnesium
  12. Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults.
    Joris PJ; Plat J; Bakker SJ; Mensink RP · Scientific reports · 2018
    Randomized trial52 participantsHeart Health forMagnesium
  13. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  14. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  15. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  16. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  17. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  18. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  19. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  20. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  21. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  22. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  23. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  24. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  25. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  26. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  27. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  28. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  29. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  30. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  31. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  32. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  33. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  34. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  35. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  36. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  37. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  38. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  39. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  40. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  41. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  42. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  43. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  44. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsBone Health forZinc
  45. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsBone Health forZinc
  46. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsBone Health forZinc
  47. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  48. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledBone Health forZinc
  49. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  50. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  51. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  52. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  53. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  54. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  55. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  56. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  57. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  58. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  59. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  60. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  61. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support forVitamin B6
  62. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  63. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  64. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy Fitness forMagnesium
  65. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  66. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  67. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsFitness forMagnesium
  68. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
    Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study2,570 participantsFitness forMagnesium
  69. Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
    Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; Martín-Vallejo J; Barbero-Iglesias FJ; Montero-Errasquín B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
    Randomized trial80 participantsFitness forMagnesium
  70. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forMagnesium
  71. Longitudinal Association Between Sodium and Potassium Intake and Physical Performance in Older Adults.
    Lana A; Struijk EA; Ortolá R; Rodríguez-Artalejo F; Lopez-Garcia E · The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Cohort study868 participantsFitness forPotassium
  72. Exercise-induced hyperkalaemia can be reduced in human subjects by moderate training without change in skeletal muscle Na,K-ATPase concentration.
    Kjeldsen K; Nørgaard A; Hau C · European journal of clinical investigation · 1991
    Observational study15 participantsFitness forPotassium
  73. Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
    Zamani P; Shah SJ; Cohen JB; Zhao M; Yang W; Afable JL; Caturla M; Maynard H; Pourmussa B; Demastus C; Mohanty I; Miyake MM; Adusumalli S; Margulies KB; Prenner SB; Poole DC; Wilson N; Reddy R; Townsend RR; Ischiropoulos H; Cappola TP; Chirinos JA · JAMA cardiology · 2025
    Randomized trial84 participantsFitness forPotassium
  74. Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial.
    Dawson-Hughes B; Harris SS; Palermo NJ; Gilhooly CH; Shea MK; Fielding RA; Ceglia L · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Randomized trial244 participantsFitness forPotassium
  75. Exercise-Associated Muscle Cramps in Ironman-Distance Triathletes Over 3 Decades.
    Nilssen PK; Johnson KB; Hiller WDB; Miller TK; Connolly CP · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2026
    Observational study10,533 participantsFitness forPotassium
  76. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM · Complementary therapies in clinical practice · 2015
    Randomized trial113 participantsGeneral Health forBoron
  77. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; González Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R · Journal of the American Academy of Dermatology · 2015
    Randomized trialGeneral Health forBoron
  78. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT · Journal of drugs in dermatology : JDD · 2015
    Clinical trial336 participantsGeneral Health forBoron
  79. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; Franzén L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2009
    Single-arm trial30 participantsGeneral Health forBoron
  80. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei · Biological Trace Element Research · 2015
    Randomized trial78 participantsGeneral Health forBoron
  81. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  82. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  83. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  84. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  85. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  86. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  87. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  88. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  89. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  90. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  91. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  92. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  93. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  94. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  95. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  96. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  97. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  98. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  99. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  100. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  101. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  102. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  103. Influence of folic acid on postprandial endothelial dysfunction.
    Wilmink HW; Stroes ES; Erkelens WD; Gerritsen WB; Wever R; Banga JD; Rabelink TJ · Arteriosclerosis, thrombosis, and vascular biology · 2000
    Randomized trial20 participantsStress Relief forFolate
  104. The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial.
    Bahmani F; Karamali M; Shakeri H; Asemi Z · Clinical endocrinology · 2015
    Randomized trial69 participantsStress Relief forFolate
  105. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
    Taylor MJ; Carney SM; Goodwin GM; Geddes JR · Journal of psychopharmacology (Oxford, England) · 2004
    Meta-analysis247 participants3 studies pooledStress Relief forFolate
  106. Depressive symptoms and associated factors among women preparing for pregnancy: a population-based study from the Seoul metropolitan preconception health management program.
    Lee HJ; Shin W; Han JY; Choi HZ; Kang J; Woo SY · BMC women's health · 2026
    Cross-sectional study14,004 participantsStress Relief forFolate
  107. Folate administration decreases oxidative status and blood pressure in postmenopausal women.
    Cagnacci A; Cannoletta M; Xholli A; Piacenti I; Palma F; Palmieri B · European journal of nutrition · 2016
    Randomized trial30 participantsStress Relief forFolate
  108. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  109. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  110. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  111. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  112. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium