Product Image

Magnesium Plus Orange-Vanilla Flavor

Pure Essence Ionic-Fizz
4.8
★ ★ ★ ★ ★
(492 ratings)
Folate 50 mcg
Potassium 100 mg
Magnesium 300 mg
Product Image
Score77
A convenient long-supply magnesium powder with useful vitamin C and methylfolate. Carbonate magnesium and cyanocobalamin hold back the ingredient quality.
How scoring works
Quantity:12 Ounce(s) • (60 servings)
Goals:
Energy
General Health
Cardiovascular Support
Heart Health
Bone Health
Sleep Support

Score 77

A convenient long-supply magnesium powder with useful vitamin C and methylfolate. Carbonate magnesium and cyanocobalamin hold back the ingredient quality.
How scoring works

Also available as

5 options
Raspberry Lemonade Flavor B9 50 mcg, Magnesium 300 mg +1 more • 12 Ounce(s) • 60 servings $40.75 ($0.67 per serving) Mixed Berry Flavor B9 50 mcg, Magnesium 300 mg +1 more • 12 Ounce(s) • 60 servings $40.58 ($0.67 per serving) Raspberry Lemonade Flavor B9 50 mcg, Magnesium 300 mg +1 more • 6 Ounce(s) • 30 servings $22.32 ($0.74 per serving) Mixed Berry Flavor B9 50 mcg, Magnesium 300 mg +1 more • 6 Ounce(s) • 30 servings $22.32 ($0.74 per serving) 6 servings B9 50 mcg, Magnesium 300 mg +1 more • 6 Ounce(s) • 30 servings $25.41 ($0.84 per serving)
$37.01($0.61 per serving)
iHerb
$ 40.24
iHerb
$ 40.24
Vitacost
$ 40.25
Walmart
$ 37.01
Pure Formulas
$ 40.25
Report prices

Analysis

The drink supplies enough magnesium to make a meaningful contribution to muscle, nerve, and energy metabolism. Vitamin C, methylfolate, potassium, and trace minerals provide a broader nutritional frame.

Magnesium carbonate is less attractive than citrate or glycinate, and this version uses cyanocobalamin rather than methylcobalamin. The minor bamboo, sea-mineral, beet, and boron additions remain secondary.

The larger size and flavored format may support adherence for people who enjoy drink powders. Its value rests on magnesium delivery, not the many unrelated goals attached to the product.

Who is it for
  • Adults wanting a long-supply magnesium drink
  • People who prefer orange-vanilla flavor
  • Users focused mainly on magnesium intake
Best for
  • Routine magnesium supplementation
  • Powder-based mineral support
  • Muscle and nervous-system nutrition

Pros

  • Meaningful magnesium amount
  • Includes vitamin C and methylfolate
  • Longer bottle supply

Cons

  • Magnesium carbonate is a middling form
  • Uses cyanocobalamin
  • Token botanical additions

Warnings

  • Magnesium carbonate may cause loose stools, gas, or cramping.
  • Keep magnesium several hours away from thyroid medicine and certain antibiotics.
  • Supplemental magnesium and potassium require caution with impaired kidney function.

Nutrient quality

77 High impact

A substantial magnesium amount and active folate provide a useful mineral foundation. Magnesium carbonate and several lightly dosed supporting ingredients limit absorption quality and formula depth.

Ingredient transparency

82 Highest impact

All listed actives have separate amounts and no proprietary blend hides the mineral formula. Complete mixing guidance and flavor-system ingredients are not supplied, while several botanical names lack standardization.

Customer satisfaction

74 High impact

The exceptional average rating is supported by a moderate review base. No review excerpts describe tolerance, ease of use, or repeated complaints, so those experiences remain uncertain.

Value for money

74 High impact

The larger package improves ongoing value, although the vitamin B12 form is less favorable. The weaker magnesium form and token secondary additions keep quality below the strongest mineral powders.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A- Goal FitA- Strength of SupportB CoverageB- Formula Quality
Vitamin D · 2.5 mcgMagnesium · 300 mgVitamin B12 · 30 mcgPotassium · 100 mg

A substantial magnesium amount and useful vitamin C dose provide the clearest foundational support for muscles, nerves, energy metabolism, and antioxidant defenses. Several B vitamins and trace minerals broaden the drink, although many are modestly dosed.

Most active forms and amounts are transparent, but the botanical and sea-mineral additions add little assessable depth. The 300 mg magnesium serving may cause loose stools or cramping when combined with other magnesium sources.

Study evidence
Magnesium Supportive 4 studies
General Health
General Health
Impact
High effect
A Goal FitC+ Strength of SupportB CoverageC+ Formula Quality
Folate · 50 mcgVitamin B12 · 30 mcgVitamin D · 2.5 mcgMagnesium · 300 mgBoron · 500 mcgZinc · 2 mgVitamin C · 250 mg

Magnesium anchors a broad mix of nutrients that may support muscle, nerve, energy, and antioxidant functions. Vitamin C is meaningful, while several other vitamins and minerals are included only in modest amounts.

Magnesium carbonate is less attractive than well-absorbed chelated forms, and cyanocobalamin is a basic vitamin B12 form. The magnesium amount may cause loose stools or stomach upset in sensitive users.

Study evidence
Boron Supportive 6 studies
Magnesium Supportive 114 studies
Vitamin C Supportive 56 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B+ Goal FitB- Strength of SupportC CoverageB- Formula Quality
Potassium · 100 mgMagnesium · 300 mgVitamin D · 2.5 mcgVitamin B12 · 30 mcgVitamin B6 · 1 mgFolate · 50 mcgVitamin C · 250 mg

Magnesium supplies the main cardiovascular benefit through support for vascular tone, blood-pressure regulation, and normal heart rhythm. The disclosed amount is meaningful, while the folate, vitamin B6, and potassium amounts add only modest support.

The formula also includes active B-vitamin forms and antioxidant vitamin C, but magnesium carbonate is not a preferred absorbable form. Several minor minerals and botanicals add breadth without a clear cardiovascular contribution.

Study evidence
Folate Supportive 93 studies
Magnesium Supportive 123 studies
Potassium Supportive 117 studies
Vitamin B6 Supportive 35 studies
Vitamin C Supportive 101 studies
Heart Health
Heart Health
Impact
High effect
B- Goal FitB+ Strength of SupportC+ CoverageC Formula Quality
Magnesium · 300 mgVitamin B12 · 30 mcgVitamin B6 · 1 mgFolate · 50 mcgVitamin D · 2.5 mcg

Magnesium at 300 mg provides meaningful foundational cardiovascular support, while methylated B vitamins may aid homocysteine metabolism. The formula lacks a meaningful direct vascular-tone ingredient.

Magnesium carbonate is clearly disclosed, and cyanocobalamin is a less preferred B12 form. Numerous trace minerals and tiny botanical additions make the formula broader on the label than in functional cardiovascular depth.

Study evidence
Magnesium Supportive 158 studies
Bone Health
Bone Health
Impact
High effect
B Goal FitB- Strength of SupportC+ CoverageC Formula Quality
Magnesium · 300 mgVitamin D · 2.5 mcgCopper · 0.25 mgManganese · 1 mgBoron · 500 mcgZinc · 2 mgVitamin C · 250 mg

Magnesium provides a meaningful mineral contribution to bone formation and vitamin D function. Small amounts of vitamin D3, zinc, copper, manganese, and boron add related support but are not substantial enough to make the formula comprehensive.

The magnesium amount is useful, although magnesium carbonate is less appealing than citrate or a well-defined chelate. Many added vitamins and plant powders broaden the label more than they deepen skeletal support.

Study evidence
Boron Supportive 5 studies
Copper Disputed 20 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Vitamin D Supportive 202 studies
Zinc Supportive 33 studies
Sleep Support
Sleep Support
Impact
High effect
B- Goal FitB Strength of SupportC CoverageD Formula Quality
Magnesium · 300 mg

Magnesium may support relaxation and sleep quality when intake is inadequate. The serving provides 300 mg as magnesium carbonate in a broad vitamin-and-mineral drink mix.

Magnesium carbonate is less preferred for bedtime use than glycinate, and the amount may cause digestive discomfort in sensitive users. Numerous vitamins, minerals, and botanical extras add complexity without creating another strong sleep pathway.

Study evidence
Magnesium Supportive 23 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 150 mcg
Vitamin C (Ascorbic Acid)
 250 mg
Vitamin D3
2.5 mcg
Vitamin B6 (Pyridoxine Hydrochloride)
 1 mg
Folate (L-5-Methyltetrahydrofolate)
 50 mcg
Vitamin B12 (Cyanocobalamin)
 30 mcg
Magnesium (Magnesium Carbonate)
 300 mg
Zinc (Zinc Lactate)
 2 mg
Copper (Copper Gluconate)
 0.25 mg
Manganese (Manganese Gluconate)
 1 mg
Potassium (Potassium Bicarbonate)
 100 mg
Bamboo extract
60 mg
ionic Sea Minerals
10 mg
Boron (Boron Citrate)
 500 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
Folate (L-5-Methyltetrahydrofolate) · 50 mcg OverallScore73
A Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyB+ Value

L-5-MTHF provides a body-ready form, while its amount is very low for general folate support. The dose disclosure is clear despite omitting explicit DFE wording, and adequate B12 supports masking-risk safeguards. Cost efficiency is strong for the active folate delivered.

View ingredientView products
Potassium (Potassium Bicarbonate) · 100 mg OverallScore65
A+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyF Value

A premium potassium bicarbonate form supports absorption and buffering. The dose remains low and the label only implies, rather than fully demonstrates, elemental yield. Moderate cost produces limited potassium value.

View ingredientView products
Magnesium (Magnesium Carbonate) · 300 mg OverallScore50
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Uses low-bioavailability magnesium carbonate at a therapeutic elemental amount. Vitamin B6, vitamin D, or boron adds relevant formulation support. High cost and a primary oxide or carbonate source weaken value.

View ingredientView products
Loading alternative details
82 Performance

MagSoothe Tart Raspberry Lemonade Flavor

Jigsaw Health
<p>Magnesium lysinate glycinate offers a more favorable form than magnesium carbonate, while potassium bicarbonate preserves useful electrolyte coverage in a simpler formula. Magnesium is lower and folate is absent, but the ingredient list is easier to assess.</p>
79 Performance

Target-Mins Magnesium Potassium Aspartate

Country Life
<p>Several organic magnesium and potassium forms broaden mineral coverage and raise the listed amounts. Magnesium oxide and apparently repeated totals reduce confidence, while folate, methylcobalamin, and the original’s wider vitamin profile are omitted.</p>
72 Performance

Super D-K Calcium Plus Raspberry Lemonade Flavor

Pure Essence Ionic-Fizz
<p>Calcium, magnesium, vitamin D3, vitamin K2, methylfolate, potassium, and boron create broader bone-oriented coverage. Magnesium remains carbonate and the drink base is incompletely disclosed, but the mineral-and-vitamin combination is more coherent for bone support.</p>
80 Budget

Target-Mins Magnesium Potassium Aspartate With Other Target-Mins Chelates

Country Life
<p>A lower-cost formula provides magnesium and potassium across several listed forms, including citrate and taurinate. The repeated full amounts make the true totals unclear, magnesium oxide lowers form quality, and folate plus the broader vitamin profile are absent.</p>
79 Budget

MagSRT

Jigsaw Health
<p>Magnesium malate, active P-5-P, methylfolate, and methylcobalamin provide better form quality and a more meaningful folate amount. The large magnesium amount may upset sensitive stomachs, and the serving cost is not lower for the least expensive original variants.</p>
79 Budget

Magnesium Plus Mixed Berry Flavor

Pure Essence Ionic-Fizz
<p>The same magnesium carbonate, potassium bicarbonate, methylfolate, methylcobalamin, vitamins, and trace minerals preserve the closest ingredient match with better serving value. Core limitations are unchanged, including the less favorable magnesium form and several token additions.</p>
81 Value

MagSoothe Tart Raspberry Lemonade Flavor

Jigsaw Health
<p>Magnesium lysinate glycinate and potassium bicarbonate provide stronger mineral forms in a concise drink mix. The serving value is weaker than the original variants, and lower magnesium plus no folate make it a quality trade rather than an economy upgrade.</p>
66 Value

Calcium Plus Raspberry Lemonade Flavor

Pure Essence Ionic-Fizz
<p>A lower-cost serving keeps the original’s magnesium, potassium, methylfolate, methylcobalamin, vitamins, and trace minerals while adding a calcium entry. The supplied calcium amount appears implausibly low, so its added bone-support value cannot be trusted without label verification.</p>
71 Value

Pink 1000 mg Vitamin C Pink Lemonade

Emergen-C
<p>A low-cost drink mix adds far more vitamin C and more listed potassium while retaining small amounts of folate and magnesium. Basic mineral forms, notable carbohydrates, and duplicated entries make it a weaker fit for magnesium, sleep, and stress goals.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  2. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  3. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy Fitness forMagnesium
  4. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  5. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  6. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  7. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  8. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  9. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  10. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  11. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  12. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  13. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  14. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  15. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  16. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  17. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  18. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  19. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  20. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  21. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  22. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  23. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  24. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  25. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  26. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  27. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  28. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  29. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  30. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsBone Health forZinc
  31. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsBone Health forZinc
  32. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsBone Health forZinc
  33. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  34. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledBone Health forZinc
  35. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  36. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  37. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  38. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  39. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  40. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  41. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  42. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  43. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  44. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  45. Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies.
    Gan L; Zhao B; Inoue-Choi M; Liao LM; Graubard BI; Weinstein SJ; Albanes D; Huang J · BMC medicine · 2024
    Meta-analysis416,104 participantsCardiovascular Support forPotassium
  46. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P · Journal of the American College of Cardiology · 2011
    Meta-analysis247,510 participants11 studies pooledCardiovascular Support forPotassium
  47. Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials.
    Geleijnse JM; Kok FJ; Grobbee DE · Journal of human hypertension · 2003
    Meta-analysis27 studies pooledCardiovascular Support forPotassium
  48. Twenty-Four-Hour Urinary Sodium and Potassium Excretion and Their Associations With Blood Pressure Among Adults in China: Baseline Survey of Action on Salt China.
    Li Y; Zhang P; Wu J; Ma J; Xu J; Zhang X; Luo R; Liu M; Sun Y; Li X; Tan M; He FJ; MacGregor GA; Li X · Hypertension (Dallas, Tex. : 1979) · 2021
    Cross-sectional study5,353 participantsCardiovascular Support forPotassium
  49. Dietary Sodium and Potassium Intake and Risk of Non-Fatal Cardiovascular Diseases: The Million Veteran Program.
    Wang DD; Li Y; Nguyen XT; Song RJ; Ho YL; Hu FB; Willett WC; Wilson PWF; Cho K; Gaziano JM; Djoussé L; On Behalf Of The Va Million Veteran Program · Nutrients · 2022
    Cohort study180,156 participantsCardiovascular Support forPotassium
  50. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  51. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  52. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  53. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support forVitamin B6
  54. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  55. Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
    Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
    Meta-analysis872 participants7 studies pooledCardiovascular Support forVitamin C
  56. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
    Clinical trial49 participantsCardiovascular Support forVitamin C
  57. Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
    Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
    Randomized trial24 participantsCardiovascular Support forVitamin C
  58. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
    Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
    Randomized trial58 participantsCardiovascular Support forVitamin C
  59. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
    Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
    Randomized trial30 participantsCardiovascular Support forVitamin C
  60. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsFitness forMagnesium
  61. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
    Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study2,570 participantsFitness forMagnesium
  62. Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
    Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; Martín-Vallejo J; Barbero-Iglesias FJ; Montero-Errasquín B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
    Randomized trial80 participantsFitness forMagnesium
  63. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forMagnesium
  64. Longitudinal Association Between Sodium and Potassium Intake and Physical Performance in Older Adults.
    Lana A; Struijk EA; Ortolá R; Rodríguez-Artalejo F; Lopez-Garcia E · The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Cohort study868 participantsFitness forPotassium
  65. Exercise-induced hyperkalaemia can be reduced in human subjects by moderate training without change in skeletal muscle Na,K-ATPase concentration.
    Kjeldsen K; Nørgaard A; Hau C · European journal of clinical investigation · 1991
    Observational study15 participantsFitness forPotassium
  66. Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
    Zamani P; Shah SJ; Cohen JB; Zhao M; Yang W; Afable JL; Caturla M; Maynard H; Pourmussa B; Demastus C; Mohanty I; Miyake MM; Adusumalli S; Margulies KB; Prenner SB; Poole DC; Wilson N; Reddy R; Townsend RR; Ischiropoulos H; Cappola TP; Chirinos JA · JAMA cardiology · 2025
    Randomized trial84 participantsFitness forPotassium
  67. Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial.
    Dawson-Hughes B; Harris SS; Palermo NJ; Gilhooly CH; Shea MK; Fielding RA; Ceglia L · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Randomized trial244 participantsFitness forPotassium
  68. Exercise-Associated Muscle Cramps in Ironman-Distance Triathletes Over 3 Decades.
    Nilssen PK; Johnson KB; Hiller WDB; Miller TK; Connolly CP · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2026
    Observational study10,533 participantsFitness forPotassium
  69. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM · Complementary therapies in clinical practice · 2015
    Randomized trial113 participantsGeneral Health forBoron
  70. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; González Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R · Journal of the American Academy of Dermatology · 2015
    Randomized trialGeneral Health forBoron
  71. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT · Journal of drugs in dermatology : JDD · 2015
    Clinical trial336 participantsGeneral Health forBoron
  72. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; Franzén L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2009
    Single-arm trial30 participantsGeneral Health forBoron
  73. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei · Biological Trace Element Research · 2015
    Randomized trial78 participantsGeneral Health forBoron
  74. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  75. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  76. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  77. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  78. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  79. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  80. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  81. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  82. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  83. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  84. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  85. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  86. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  87. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  88. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  89. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  90. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  91. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  92. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  93. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  94. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  95. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  96. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  97. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  98. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  99. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  100. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6