Product Image

B-Complex '100'

Solgar
4.7
★ ★ ★ ★ ★
(30198 ratings)
Thiamin 100 mg
Niacin 100 mg
Riboflavin 100 mg
Vitamin B5 100 mg
Vitamin B6 100 mg
Choline 20 mg
Vitamin B12 100 mcg
Product Image
Score80

A complete high-potency capsule with a generous supply but ordinary forms. The 100 mg vitamin B6 amount limits long-term daily suitability.

How scoring works
Quantity:250 Capsule(s) • (250 servings)
Goals:
Energy
General Health
Metabolism Boost

Score 80

A complete high-potency capsule with a generous supply but ordinary forms. The 100 mg vitamin B6 amount limits long-term daily suitability.

How scoring works

Also available as

4 options
50 mg • 250 Capsule(s) servings 50 mg • 250 Capsule(s) • 250 servings $25.87 ($0.10 per serving) 100 servings 1 Vegetable Capsule(s) • 100 Capsule(s) • 100 servings $11.96 ($0.11 per serving) 50 mg • 100 Capsule(s) servings 50 mg • 100 Capsule(s) • 100 servings $11.96 ($0.11 per serving) 50 servings 1 Vegetable Capsule(s) • 50 Capsule(s) • 50 servings $11.02 ($0.22 per serving)
$41.94($0.16 per serving)
iHerb
$ 42.09
Vitacost
$ 43.79
Vitacost
$ 43.79
Daily Vita
$ 48.67
Amazon
$ 41.94
Report prices

Analysis

The capsule delivers 100 mg each of thiamine, riboflavin, niacin, vitamin B6, and pantothenic acid. Folate, cyanocobalamin, biotin, choline, and inositol fill out the profile.

Most forms are conventional, and 20 mg choline is small relative to ordinary nutritional intake. The pyridoxine amount is high enough to make cumulative exposure important.

A generous serving supply adds convenience for people who have selected this dose intentionally. For general wellness, a lower vitamin B6 amount would be easier to use safely over time.

Who is it for
  • Adults intentionally seeking a B-100 formula
  • Capsule users
  • People using high-dose B vitamins with guidance
Best for
  • Short-term high-potency B coverage
  • Energy metabolism support
  • Broad B-complex intake

Pros

  • Complete B-vitamin profile
  • Clearly stated amounts
  • Large serving supply
  • Includes inositol

Cons

  • 100 mg vitamin B6 is very high
  • Mostly conventional forms
  • Only 20 mg choline
  • Not ideal for unrestricted daily use

Warnings

  • Prolonged daily use of 100 mg vitamin B6 may cause nerve symptoms
  • Do not combine it with another high-dose vitamin B6 product
  • Seek professional advice if tingling or numbness appears

Nutrient quality

68 High impact

The complete B-vitamin profile provides substantial metabolic cofactors in a focused formula. Conventional forms and an excessive vitamin B6 amount make the design less suitable for routine long-term use.

Ingredient transparency

84 Highest impact

The major B vitamins have separate amounts and no hidden blend obscures the core formula. Complete usage directions and the inactive-ingredient list are not supplied here.

Customer satisfaction

78 High impact

The very strong average rating is supported by an exceptionally large review base. No review excerpts describe tolerance, effectiveness, or repeated complaints, so those experiences remain uncertain.

Value for money

91 Highest impact

A very long supply and focused capsule provide excellent economic value. The excessive vitamin B6 amount limits value for routine long-term supplementation.

Report analysis

Goals

Energy
Energy
Impact
High effect
B+ Goal FitB- Strength of SupportC CoverageA Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A high-potency B-complex supplies the cofactors needed for carbohydrate, fat, and protein metabolism. Substantial thiamin, riboflavin, niacin, and pantothenic acid create focused support for cellular energy production.

Cyanocobalamin remains below the targeted B12 range for energy, and the formula does not address alertness or stress adaptation. The very high pyridoxine amount raises concern for prolonged daily use because excess vitamin B6 can affect nerves.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
A- Goal FitC Strength of SupportB- CoverageB+ Formula Quality
Folate · 666 mcg DFEVitamin B12 · 100 mcg

The broad B-vitamin formula supports energy metabolism and helps cover several common nutritional gaps. Most amounts are clearly stated, but cyanocobalamin and pyridoxine are basic rather than preferred active forms.

The very high vitamin B6 amount makes the formula less suitable for routine long-term use without a specific need. People using it daily should consider total vitamin B6 intake because sustained high exposure can harm peripheral nerves.

Study evidence
Vitamin B12 Adverse 66 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C Goal FitB- Strength of SupportC CoverageA- Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

The concentrated B-vitamin blend supplies broad cofactor support for cellular energy production. It may help when intake is inadequate, but it is not a direct thermogenic or fat-oxidation formula.

Most amounts are fully disclosed and substantial, while the vitamin forms are generally conventional. The pyridoxine amount is high for routine long-term use, which weakens the practical dose profile despite the formula's focus.

Study evidence
Vitamin B6 Supportive 16 studies
Heart Health
Heart Health
Impact
Moderate effect
C Goal FitD Strength of SupportC- CoverageB Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 666 mcg DFE

B vitamins provide a coherent homocysteine-support pathway, but the formula uses standard rather than preferred forms for several key nutrients. The very high vitamin B6 amount also makes long-term daily use less appealing.

Coverage stays largely within one metabolic pathway and does not include lipid, vascular-tone, or cellular-energy actives. Prolonged intake of 100 mg pyridoxine may increase neuropathy risk.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
D Goal FitC- Strength of SupportD CoverageC Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 666 mcg DFENiacin · 100 mg

B vitamins support homocysteine metabolism and general energy pathways that can matter for cardiovascular health. The formula is not a targeted heart product because it lacks magnesium, omega-3 fats, CoQ10, or a nitric-oxide active.

Folate and B12 are present, but cyanocobalamin and conventional pyridoxine reduce form quality. The 100 mg vitamin B6 amount reaches a chronic-use ceiling and may raise the risk of sensory nerve symptoms with prolonged daily use.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Mononitrate, Vitamin B1)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide, Vitamin B3)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
666 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Biotin (D-Biotin)
 100 mcg
Pantothenic Acid (D-Calcium Pantothenate, Vitamin B5)
 100 mg
Choline (Choline Bitartrate)
 20 mg
Inositol
100 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Halal Vegetarian
Report overview
Thiamin (Thiamine Mononitrate, Vitamin B1) · 100 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

A high-potency thiamin dose uses a standard water-soluble form and is fully disclosed. The conventional capsule provides ordinary delivery quality without a premium absorption system. Value is excellent for a broad formula priced below the collection norm.

View ingredientView products
Niacin (Niacinamide, Vitamin B3) · 100 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

The B-complex provides a substantial niacinamide amount for general nutritional use. A standard capsule offers no special release control, while the clearly disclosed form keeps classic flushing unlikely. Its serving cost is favorable for the amount and the wider B-vitamin profile.

View ingredientView products
Riboflavin (Vitamin B2) · 100 mg OverallScore77
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Standard riboflavin requires enzymatic conversion before it becomes metabolically active, while the capsule should dissolve readily. The amount reaches the high-potency range for metabolic support. The low serving cost makes the clearly stated dose highly efficient.

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Loading alternative details
85 Performance

BioCoenzymated Active B Complex

Natural Factors
Active thiamine, riboflavin, vitamin B6, folate, and vitamin B12 provide a more refined form profile than a mostly conventional B-complex. The formula remains potent, but its more moderate vitamin B6 amount improves routine-use balance.
83 Performance

Advanced B Complex

AOR Advanced Orthomolecular Research Advanced
Benfotiamine, active riboflavin, P-5-P, methylfolate, methylcobalamin, and pantethine create a substantially more refined B-complex. Several amounts are still high enough that stacking with fortified products should be deliberate, and the niacin form is unclear.
81 Performance

Coenzyme B-Complex Caps

Country Life
Multiple coenzyme forms improve ingredient quality while maintaining meaningful B-vitamin amounts. Vitamin B6 remains elevated for prolonged use and choline is modest, but the larger supply supports practical value.
76 Budget

B-100

NOW
Broad B-vitamin coverage keeps serving cost low for targeted high-potency use. Most forms are conventional, and very high pyridoxine may raise the risk of tingling, numbness, or other nerve symptoms with prolonged use.
79 Budget

B-100 Complex

21st Century
A broad high-potency profile provides economical energy-metabolism support with clearly stated amounts. Conventional forms and vitamin B6 at the chronic-use safety ceiling make unsupervised daily use a poor fit.
74 Budget

B-Complex '50'

Solgar
Broad B-vitamin coverage offers a lower-potency and inexpensive alternative to a B-100 formula. The forms remain conventional, and vitamin B6 is still unnecessarily high for prolonged daily use.
77 Value

B-50 Complex

Nature's Way
Active riboflavin improves a broad B-complex base while the lower-potency format supports favorable serving value. Vitamin B6 remains unnecessarily high for long-term daily use despite the more balanced direction.
76 Value

Megasorb B-Complex '50'

Solgar
Active riboflavin and vitamin B6 forms add quality within a more economical B-50 profile. The vitamin B6 amount is still aggressive, so prolonged daily use deserves caution.
75 Value

Sustained Release B-100

NOW
Broad high-potency coverage and strong serving value make this a practical option when a B-100 dose is specifically wanted. Most forms are conventional, and very high pyridoxine may raise nerve-symptom risk with prolonged daily use.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  2. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  3. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  4. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  5. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  6. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  7. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  8. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  9. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  10. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  11. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  12. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  13. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  14. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  15. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  16. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  17. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  18. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  19. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  20. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  21. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  22. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  23. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  24. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  25. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  26. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  27. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  28. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  29. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  30. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  31. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  32. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  33. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  34. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  35. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  36. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  37. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  38. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  39. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  40. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  41. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  42. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  43. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  44. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  45. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  46. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  47. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  48. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  49. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  50. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  51. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  52. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6