Vitamin K
Vitamin K is a group of fat-soluble vitamins that are vital for various bodily functions. The two primary forms are Vitamin K1 (phylloquinone), found mainly in plant foods, and Vitamin K2 (menaquinone), found in animal products and fermented foods, and also produced by gut bacteria. Both forms are crucial, but K2 is gaining recognition for its broader systemic benefits. Its most well-known function is its role in blood coagulation. Vitamin K acts as a coenzyme for the enzyme gamma-glutamyl carboxylase, which is necessary for the activation of several clotting factors in the liver. Without adequate Vitamin K, the blood's ability to clot effectively is impaired, leading to excessive bleeding. Beyond clotting, Vitamin K is also critical for bone health. It activates proteins like osteocalcin, which helps bind calcium to the bone matrix, and Matrix Gla Protein (MGP), which prevents calcium deposition in soft tissues like arteries. This dual action contributes to strong bones and cardiovascular health, preventing arterial calcification.
Leafy green vegetables (kale, spinach, collard greens, Swiss chard)BroccoliBrussels sproutsCabbageNatto (fermented soybeans - particularly rich in K2)Meat (liver, chicken)EggsHard cheesesFermented foods
Cheapest Vitamin K supplements
Discover the most affordable Vitamin K supplements to support your heart, bone, and general health, aiding in cardiovascular support, joint health, and anti-aging benefits.
Best Vitamin K supplements
Explore our top picks for Vitamin K supplements, essential for supporting crucial functions like bone mineralization, cardiovascular health, and overall vitality to achieve your heart health, joint health, and anti-aging goals.
Value Vitamin K Supplements
Explore and compare top value Vitamin K supplements, essential for supporting bone and heart health, cardiovascular function, and overall well-being and anti-aging goals.
RDA (Men)120 mcg
RDA (Women)90 mcg
RDI120 mcg
Minimum100 mcg
Maximum200 mcg
Toxicity Effectno known toxicity
Impact
Highest effect
Vitamin K2, in particular, activates proteins like osteocalcin and Matrix Gla Protein (MGP). Osteocalcin helps bind calcium to the bone matrix, while MGP prevents calcium from depositing in soft tissues like arteries and blood vessels. This dual action is fundamental for maintaining both skeletal strength and cardiovascular flexibility with age.
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Impact
Highest effect
Typical dose:90–200 mcg
Specifically, Vitamin K2 (menaquinone) is critical for directing calcium into the bones and teeth and away from soft tissues like arteries. It activates osteocalcin, a protein that incorporates calcium into bone, and Matrix Gla Protein (MGP), which prevents vascular calcification.
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Impact
Highest effect
Typical dose:90–200 mcg
While often known for blood clotting (Vitamin K1), the K2 form (specifically MK-7) is vital for cardiovascular health. It activates proteins that inhibit calcium deposition in arterial walls, a key factor in atherosclerosis and arterial stiffening. This helps maintain blood vessel elasticity and function.
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Impact
Highest effect
Typical dose:100–200 mcg
Primarily in its K2 form, this vitamin is crucial for proper calcium metabolism. It activates proteins that help bind calcium to the bone matrix and prevent its accumulation in soft tissues like arteries, where it can cause calcification. It is an essential partner to Vitamin D supplementation.
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Impact
Highest effect
Typical dose:100–200 mcg
The K2 form (specifically MK-7) activates matrix Gla-protein (MGP), the most potent inhibitor of vascular calcification. By ensuring calcium is deposited in bone rather than soft tissues, Vitamin K2 directly contributes to maintaining arterial flexibility and preventing stiffness.
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add_circle_outline Positive Interactions
Calcium
Vitamin K helps activate proteins (like osteocalcin) that are essential for binding Calcium into the bone matrix, promoting stronger bones.
Vitamin D
Vitamin K and Vitamin D work synergistically to regulate Calcium metabolism, promoting bone mineralization and preventing arterial calcification. Vitamin D aids Calcium absorption, while Vitamin K directs it to the bones.
Magnesium
Magnesium is involved in bone formation and works with Vitamin K and Vitamin D to support overall bone health and mineral density.
remove_circle_outline Negative Interactions
Vitamin E
High doses of Vitamin E may interfere with Vitamin K's absorption and metabolism, potentially exacerbating bleeding in susceptible individuals.
Vitamin A
Very high doses of Vitamin A may interfere with Vitamin K absorption and function, potentially affecting blood clotting.
72 Value 
One Daily Men's Health with Lycopene
21st Century
4.7
★★★★★
(29081 ratings)
Vitamin K: 20 mcg
This multivitamin serves as a general daily nutritional support for men, offering essential vitamins and minerals along with lycopene in a convenient, affordable tablet form.
68 Value 
Therapeutic-M
21st Century
4.7
★★★★★
(615 ratings)
Vitamin K: 28 mcg
Therapeutic-M is a cost-effective multivitamin-mineral supplement designed to offer broad, everyday nutritional support for general wellness.
90 Best 
ADK Vitamins
Codeage
4.8
★★★★★
(2594 ratings)
Vitamin K: 1000 mcg
A comprehensive, high-potency ADK complex with multiple forms of Vitamin K, providing broad support for bone, immune, and cardiovascular health at a great value.
68 Value 
One Daily Women's
Equate
4.7
★★★★★
(5571 ratings)
Vitamin K: 25 mcg
This women's multivitamin offers a budget-conscious blend of essential vitamins and minerals, including a significant amount of Biotin, to support women's daily health needs.
65 Value 
Complete Multivitamin
Equate
4.7
★★★★★
(1663 ratings)
Vitamin K: 25 mcg
This multivitamin offers a broad range of basic vitamins and minerals to support general daily health and fill common nutritional gaps at an economical price.
78 Best 
Vitamin K2 Advantage 2200 mcg
Source Naturals
4.8
★★★★★
(375 ratings)
Vitamin K: 1820 mcg
A comprehensive blend of Vitamin K1, K2 (MK-4, MK-7), and a touch of calcium, providing broad support for vitamin K needs in one tablet.
60 Value 
TriCalcium Complex with D & K
Swanson Premium Brand
4.8
★★★★★
(476 ratings)
Vitamin K: 30 mcg
This is a basic, very affordable calcium blend with low doses of Vitamin D and K1, suitable for general calcium needs.
90 Best 
Full Spectrum Vitamin K2
InnovixLabs
4.7
★★★★★
(9048 ratings)
Vitamin K: 500 mcg
This InnovixLabs supplement combines 500 mcg MK-4 and 100 mcg MK-7, offering comprehensive K2 support for bone and cardiovascular health at a great value.
72 Value 
One Daily Maximum
21st Century
4.7
★★★★★
(7795 ratings)
Vitamin K: 25 mcg
This multivitamin delivers a broad spectrum of essential vitamins and minerals at a very accessible price point, designed for general daily nutritional support.
70 Value 
One Daily Women's
21st Century
4.7
★★★★★
(34510 ratings)
Vitamin K: 25 mcg
This women's multivitamin offers a comprehensive, budget-friendly blend of essential vitamins and minerals, including a high dose of Biotin, to support daily health and specific needs like hair and nail wellness.
68 Value 
One Daily Men's Health
Equate
4.7
★★★★★
(2147 ratings)
Vitamin K: 20 mcg
This is a comprehensive and budget-friendly multivitamin for men, providing a wide array of essential vitamins and minerals for daily nutritional support.
78 Best 
Vitamin K2 Advantage 2200 mcg
Source Naturals
4.8
★★★★★
(375 ratings)
Vitamin K: 1820 mcg
A comprehensive Vitamin K complex with K1, K2 (MK-4, MK-7), and a touch of calcium, providing broad support for blood, bone, and heart health.
89 Best 
Wellness Essentials Women's Prime
Metagenics
4.8
★★★★★
(41 ratings)
Vitamin K: 1060 mcg
This is a comprehensive daily packet system for women, packed with a wide range of vitamins, minerals, and specialized extracts that support overall health, bone density, and cardiovascular function.
85 Best 
Once-Daily Health Booster
Life Extension
4.5
★★★★★
(983 ratings)
Vitamin K: 3735 mcg
This softgel offers a broad spectrum of vitamins K and E, alongside chlorophyllin, lycopene, and other plant extracts designed for comprehensive daily health support.
89 Best 
Bone Solid
Country Life
4.6
★★★★★
(769 ratings)
Vitamin K: 1010 mcg
Country Life Bone Solid is a highly comprehensive supplement designed to support robust bone health through a rich blend of essential minerals and key vitamins like D3 and K, available in a larger quantity for extended use.
70 Value 
One Daily Men's Health
Equate
4.7
★★★★★
(2147 ratings)
Vitamin K: 20 mcg
This is a standard daily multivitamin for men, providing a broad mix of essential vitamins and minerals, including lycopene, in a convenient one-tablet dose for general nutritional support.
85 Best 
Super K
Life Extension
4.7
★★★★★
(12512 ratings)
Vitamin K: 2600 mcg
A high-dose Vitamin K supplement (2600 mcg) paired with Vitamin C, aimed at broad support for bone and cardiovascular health.
88 Best 
Bone Solid
Country Life
4.6
★★★★★
(757 ratings)
Vitamin K: 1010 mcg
Country Life Bone Solid is a highly comprehensive supplement designed to support robust bone health through a rich blend of essential minerals and key vitamins like D3 and K.
70 Value 
Complete Multivitamin Adults 50+
Equate
4.7
★★★★★
(2059 ratings)
Vitamin K: 30 mcg
This multivitamin for adults 50+ offers a foundational blend of essential vitamins, minerals, and key carotenoids like Lutein and Lycopene, supporting general health, bone density, and vision at a very accessible price.
83 Best 
A-D-K Essential Vitamins
Terra Origin
4.8
★★★★★
(500 ratings)
Vitamin K: 1000 mcg
A robust blend of Vitamins A, D3 (5000 IU), and K (1000 mcg) in one capsule, targeting comprehensive fat-soluble vitamin support.
Average$31.74
Median$27.79
Average$0.79
Median$0.64
Average$0.20
Median$0.08
Reference amount: 10 mcg
Menaquinone-7 (MK-7) is a long-chain menaquinone, a type of Vitamin K2, primarily found in fermented foods like natto. It is known for its superior bioavailability and longer half-life compared to other K2 forms and K1, allowing for more sustained physiological activity. MK-7 activates Matrix Gla Protein (MGP) to prevent arterial calcification and osteocalcin to promote bone mineralization, making it crucial for cardiovascular and bone health.
- Highly bioavailable and long half-life for sustained action.
- Significant impact on bone health by promoting calcium incorporation.
- Strong preventative effect against arterial calcification for cardiovascular health.
- Can be more expensive than other Vitamin K forms.
- Primarily found in a few specific fermented foods, making dietary intake challenging without supplementation.
Avg$34.01
Med$29.99
Avg$0.84
Med$0.77
Avg$1.66
Med$0.79
Price distribution
Phytonadione is the synthetic form of Vitamin K1 (phylloquinone) and is also naturally abundant in green leafy vegetables. Its primary physiological role is as a co-factor for gamma-glutamyl carboxylase, an enzyme necessary for the synthesis of coagulation factors (II, VII, IX, X) in the liver. It is crucial for hemostasis (blood clotting) and is often administered therapeutically to reverse anticoagulant effects or treat K1 deficiency. While essential for clotting, its role in bone and cardiovascular health is less pronounced than that of Vitamin K2 forms.
- Essential for normal blood clotting and prevention of hemorrhage.
- Readily available in a wide range of common dietary sources.
- Safe at recommended daily allowance levels.
- Less effective for bone and cardiovascular health compared to Vitamin K2 forms.
- Shorter half-life than MK-7, limiting systemic benefits.
Avg$28.57
Med$24.50
Avg$0.65
Med$0.53
Avg$0.10
Med$0.06
Price distribution
Menaquinone-4 (MK-4) is a short-chain menaquinone, a form of Vitamin K2, found in animal products like meat, eggs, and dairy. Unlike other menaquinones, MK-4 can be synthesized in the body from K1 in certain tissues, although dietary intake is also a source. It has a rapid turnover and tissue-specific functions, particularly in brain, testes, and pancreas, and plays a role in bone metabolism.
- Rapidly absorbed and utilized in the body.
- Important for specific tissue functions, including brain and bone health.
- Can be synthesized endogenously from K1 in certain tissues.
- Short half-life, requiring higher or more frequent dosing for sustained systemic effects.
- Less effective for preventing arterial calcification than MK-7 at typical supplemental doses.
Avg$35.93
Med$33.64
Avg$0.85
Med$0.96
Avg$0.64
Med$0.62
Price distribution
Vitamin K1, or phylloquinone, is the most common dietary form of Vitamin K, predominantly found in plant-based foods such as spinach, kale, and broccoli. Its primary function is in the liver, where it acts as a co-factor for the enzyme gamma-glutamyl carboxylase, which is necessary for the activation of several proteins involved in blood coagulation. While crucial for clotting, its role in bone and cardiovascular health is less pronounced than that of Vitamin K2.
- Essential for blood clotting and prevention of hemorrhage.
- Widely available and easily obtainable through a healthy diet.
- Generally safe at recommended dietary intake levels.
- Less effective for bone health and preventing arterial calcification compared to K2 forms.
- Shorter half-life than MK-7, limiting sustained systemic benefits.
Avg$47.77
Med$45.50
Avg$1.09
Med$0.80
Avg$1.33
Med$0.79
Price distribution
Vitamin K2 is a collective term for a series of menaquinones (MK-n) distinguished by the length of their isoprenoid side chains (e.g., MK-4, MK-7). Found in fermented foods and animal products, K2 is vital for activating Matrix Gla Protein (MGP) and osteocalcin, which are key proteins involved in calcium regulation. This dual action helps prevent arterial calcification and promotes proper bone mineralization, offering significant benefits for cardiovascular and skeletal health.
- Crucial for both bone and cardiovascular health.
- Prevents arterial calcification by directing calcium appropriately.
- Long-chain forms (like MK-7) have high bioavailability and extended action.
- Less common in typical Western diets than K1, often requiring supplementation.
- Potential interaction with blood thinners.
Avg$33.02
Med$30.36
Avg$0.79
Med$0.60
Avg$0.81
Med$0.67
Price distribution
Menaquinone refers to a group of fat-soluble compounds collectively known as Vitamin K2. These compounds are characterized by their isoprenoid side chains of varying lengths (e.g., MK-4, MK-7). Menaquinones are crucial for the activation of proteins involved in calcium metabolism, such as osteocalcin (for bone) and Matrix Gla Protein (MGP, for vascular health), helping to direct calcium to bones and away from soft tissues like arteries.
- Encompasses highly beneficial forms of K2, vital for bone and heart health.
- Crucial for proper calcium utilization in the body.
- A broad term, specific benefits and bioavailability depend on the particular menaquinone form (e.g., MK-4 vs. MK-7).
- Less common in typical Western diets than K1.
Avg$28.99
Med$24.23
Avg$0.71
Med$0.56
Avg$0.64
Med$0.37
Price distribution
Cabbage is a leafy green vegetable that is a good natural source of Vitamin K1 (phylloquinone). While it provides essential Vitamin K, the amount per serving is typically lower than in concentrated supplements or certain other leafy greens (like kale or spinach). Regular consumption of cabbage contributes to meeting daily Vitamin K requirements, supporting blood clotting and general health, while also providing fiber and other vitamins.
- Natural food source of Vitamin K1 and other essential nutrients.
- Provides fiber and antioxidants, contributing to overall dietary health.
- No direct risk of overconsumption of K1 from food sources.
- Lower concentration of Vitamin K compared to supplements, primarily K1 (less K2).
- Absorption of K1 from plant sources can be variable.
Avg$45.29
Med$48.49
Avg$0.89
Med$0.92
Avg$0.66
Med$0.62
Price distribution
K1, or Vitamin K1, is the form of Vitamin K found predominantly in plants, specifically green leafy vegetables. Its most well-known function is its indispensable role in the liver's synthesis of blood clotting factors, which are essential for preventing excessive bleeding. While its primary action is related to coagulation, K1 also plays a lesser role in bone metabolism compared to K2.
- Essential for blood clotting and prevention of hemorrhage.
- Readily available in a wide range of common dietary sources.
- Safe at recommended daily allowance levels.
- Less effective for bone and cardiovascular health compared to Vitamin K2 forms.
- Shorter half-life than MK-7, limiting systemic benefits.
Avg$36.78
Med$34.29
Avg$0.89
Med$1.01
Avg$0.69
Med$0.72
Price distribution