Prenatal Folic Acid + DHA

Prenatal Folic Acid + DHA

Nature Made4.4 (3,291 ratings)
Format:Softgel
Goals
$16.98 $0.00 per serving

Product analysis

53 out of 100

Prenatal Folic Acid + DHA supplies nutrients for normal blood formation and bone nutrition, particularly when dietary intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality39

Iodine uses a favorable form, while vitamin K uses a less favored form and omega-3 fats use ethyl esters. Several other forms are unspecified or cannot be confidently compared.

Ingredient Transparency74

Amounts and most forms are stated. Missing preparations and incomplete oil-component details limit a full comparison of the contents.

Value For Money40

Value cannot be judged confidently for the listed nutrients. A meaningful comparison needs usable pricing and serving information.

Customer Satisfaction80

Customer feedback is generally positive across thousands of reviews. The broad review history supports satisfaction without establishing nutritional completeness.

Product Focus46

The clearest benefits are nutritional, particularly where low intake affects bone health or tiredness. The long ingredient list does not establish extra benefits, and the DHA amount is well below exposures linked to some heart-related effects.

Format
Softgel
Customer rating
4.4 · 3,291 ratings
Report analysis

Goals

Hair Health
Impact
Moderate effect
C+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 30 mcgVitamin D · 25 mcgZinc · 11 mgIron · 27 mgVitamin C · 85 mg
Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Iodine No effect 1 study
Iron Disputed 25 studies
Niacin Disputed 2 studies
Omega-3 Adverse 4 studies
Vitamin A Disputed 13 studies
Vitamin D Disputed 34 studies
Vitamin E No effect 3 studies
Zinc Supportive 22 studies
Impact
High effect
C+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Iodine · 150 mcgVitamin D · 25 mcgVitamin B5 · 6 mgMagnesium · 45 mgRiboflavin · 1.4 mgThiamin · 1.4 mgVitamin B12 · 5.2 mcgIron · 27 mg
Study evidence
Iodine Adverse 3 studies
Iron Supportive 74 studies
Magnesium Supportive 4 studies
Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies
Heart Health
Impact
High effect
C- Ingredient FitC PathwaysA- EvidenceA+ Formulation Logic
Vitamin K · 90 mcgMagnesium · 45 mgVitamin B12 · 5.2 mcgVitamin B6 · 1.9 mgFolate · 1330 mcg DFEVitamin D · 25 mcg
Study evidence
Folate Supportive 116 studies
Magnesium Supportive 158 studies
Niacin Supportive 105 studies
Vitamin B6 Supportive 44 studies
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Productivity Boost
Impact
Moderate effect
D+ Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
Iron · 27 mgVitamin B12 · 5.2 mcgVitamin B12 · 5.2 mcgVitamin B6 · 1.9 mgZinc · 11 mgMagnesium · 45 mgOmega-3 · 260 mg
Study evidence
Iron Supportive 69 studies
Magnesium Supportive 10 studies
Omega-3 Supportive 46 studies
Zinc Supportive 11 studies
Impact
High effect
C- Ingredient FitB+ PathwaysA+ EvidenceA Formulation Logic
Vitamin K · 90 mcgMagnesium · 45 mgCalcium · 150 mgVitamin D · 25 mcgZinc · 11 mgVitamin C · 85 mg
Study evidence
Calcium Supportive 144 studies
Folate Supportive 50 studies
Magnesium Supportive 48 studies
Omega-3 Supportive 32 studies
Vitamin A Adverse 56 studies
Vitamin C Supportive 46 studies
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Zinc Supportive 33 studies
Cardiovascular Support
Impact
High effect
C- Ingredient FitC- PathwaysB+ EvidenceA+ Formulation Logic
Vitamin K · 90 mcgMagnesium · 45 mgVitamin D · 25 mcgVitamin B12 · 5.2 mcgVitamin B6 · 1.9 mgVitamin E · 15 mgFolate · 1330 mcg DFENiacin · 18 mgVitamin C · 85 mg
Study evidence
Folate Supportive 93 studies
Magnesium Supportive 123 studies
Niacin Supportive 136 studies
Vitamin B6 Supportive 35 studies
Vitamin C Supportive 101 studies
Vitamin D Mixed 170 studies
Vitamin E Mixed 79 studies
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per servingScore
Calories
5 Calorie(s)
Vitamin A (Beta-Carotene)
770 mcg
Vitamin C (Ascorbic Acid)
85 mg
Vitamin D3 (Cholecalciferol)
25 mcg
Vitamin E (D-Alpha-Tocopherol)
15 mg
Vitamin K (Phytonadione)
90 mcg 42
Thiamine (Thiamine Mononitrate)
1.4 mg
Riboflavin
1.4 mg
Niacin (Niacinamide)
18 mg
Vitamin B6 (Pyridoxine Hydrochloride)
1.9 mg
Folate
1330 mcg DFE
Vitamin B12 (Cyanocobalamin)
5.2 mcg
Biotin
30 mcg
Pantothenic Acid (Calcium D-Pantothenate)
6 mg
Calcium (Calcium Carbonate)
150 mg
Iron (Ferrous Fumarate)
27 mg 73
Iodine (Potassium Iodide)
150 mcg 100
Magnesium (Magnesium Oxide)
45 mg
Zinc (Zinc Oxide)
11 mg
Omega-3 Fatty Acids (Ethyl Esters, Fish Oil concentrate)
260 mg 55
Gluten Free Pregnant Women 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
D- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD+ Value
A serving provides 260 mg of combined EPA and DHA, at a moderate cost per gram based on the full serving price. The omega-3 is in ethyl ester form. A purity certification is reported.
How this ingredient is rated

Active Ingredient Quality & Bioavailability42

The omega-3 is in ethyl ester form. The serving contains 15 mg of vitamin E.
Molecular Form & Absorption Potential
The omega-3 is in ethyl ester form.
Source Purity & Oxidative Protection
The serving contains 15 mg of vitamin E.

Dose, Safety & Label Transparency70

The serving lists 60 mg EPA and 200 mg DHA separately. A purity certification is reported.
EPA & DHA Label Specificity
The serving lists 60 mg EPA and 200 mg DHA separately.
Active Ingredient Concentration
EPA and DHA concentration is unclear because the matching oil amount is unavailable.
Third-Party Purity Verification
A purity certification is reported.

Value50

The cost per gram of EPA and DHA is moderate, based on the full serving price.
Price per 1000mg of EPA+DHA
The cost per gram of EPA and DHA is moderate when the full serving price is attributed to them.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  7. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsBone Health forFolate
  8. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate Bone Health forVitamin B6
  9. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsBone Health forFolate
  10. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsBone Health forFolate
  11. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  12. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  13. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  14. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  15. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  16. Habitual use of fish oil supplements, genetic predisposition, and risk of fractures: a large population-based study.
    Mei Z; Chen GC; Hu J; Lin C; Sun Z; Liu C; Geng X; Yuan C; Qi Q; Zheng Y · The American journal of clinical nutrition · 2021
    Cohort study492,713 participantsBone Health forOmega-3
  17. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
    Matsuzaki K; Hossain S; Wakatsuki H; Tanabe Y; Ohno M; Kato S; Shido O; Hashimoto M · Phytotherapy research : PTR · 2023
    Randomized trial52 participantsBone Health forOmega-3
  18. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans.
    Griel AE; Kris-Etherton PM; Hilpert KF; Zhao G; West SG; Corwin RL · Nutrition journal · 2007
    Randomized trial23 participantsBone Health forOmega-3
  19. The Relationship Between Omega-3, Omega-6 and Total Polyunsaturated Fat and Musculoskeletal Health and Functional Status in Adults: A Systematic Review and Meta-analysis of RCTs.
    Abdelhamid A; Hooper L; Sivakaran R; Hayhoe RPG; Welch A; PUFAH Group · Calcified tissue international · 2020
    Meta-analysis7,288 participants28 studies pooledBone Health forOmega-3
  20. Dietary intake of fish, n-3 polyunsaturated fatty acids and risk of hip fracture: A systematic review and meta-analysis on observational studies.
    Sadeghi O; Djafarian K; Ghorabi S; Khodadost M; Nasiri M; Shab-Bidar S · Critical reviews in food science and nutrition · 2019
    Meta-analysis292,657 participants10 studies pooledBone Health forOmega-3