Product Image

Ultimate B+C Complex

Solgar
4.7
★ ★ ★ ★ ★
(896 ratings)
Vitamin B6 50 mg
Thiamin 50 mg
Riboflavin 50 mg
Niacin 50 mg
Glutamic Acid 15 mg
Vitamin B5 50 mg
Vitamin C 1000 mg
Product Image
Score75
Broad, affordable B-plus-C coverage is the main strength, while conventional forms and a high B6 amount make daily long-term use less attractive.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
General Health
Energy
Immunity
Skin Health

Score 75

Broad, affordable B-plus-C coverage is the main strength, while conventional forms and a high B6 amount make daily long-term use less attractive.
How scoring works
$18.92($0.21 per serving)
Daily Vita
$ 20.24
iHerb
$ 18.92
Vitacost
$ 20.25
Pure Formulas
$ 20.24
Vitacost
$ 20.55
Report prices

Analysis

The formula supplies the main B vitamins plus 1,000 mg of vitamin C, giving it broad support for normal energy metabolism and antioxidant needs. Choline, inositol, bioflavonoids, and related additions widen the ingredient list but contribute only modest amounts.

Several nutrients use conventional forms, including pyridoxine hydrochloride, cyanocobalamin, and folate with no clear form disclosure. Multiple label entries for some vitamins also make the total composition less straightforward to interpret.

The single-tablet serving and favorable value are practical strengths for occasional use. A 50 mg B6 amount is aggressive for sustained daily intake, and the large vitamin C amount may be uncomfortable for sensitive stomachs.

Who is it for
  • Adults wanting a combined high-potency B-complex and vitamin C
  • People who prefer a one-tablet nutrient blend
Best for
  • Occasional high-potency B-vitamin support
  • Broad water-soluble vitamin coverage

Pros

  • Provides complete B-vitamin coverage
  • Includes a substantial vitamin C amount
  • Strong serving value for the breadth of nutrients

Cons

  • Relies mainly on conventional vitamin forms
  • Supporting bioflavonoids and related extras are lightly dosed
  • Duplicate label entries complicate interpretation

Warnings

  • Long-term daily use of 50 mg pyridoxine may raise the risk of tingling, numbness, or other nerve symptoms
  • The 1,000 mg vitamin C amount may cause stomach upset or loose stools in sensitive users

Nutrient quality

66 High impact

Several conventional forms are named, but folate is unspecified and vitamin B12 is cyanocobalamin. Vitamin C and the principal B vitamins are present in substantial amounts.

Ingredient transparency

79 High impact

Specific amounts are listed for all supplied active ingredients. The supplied data omit inactive tablet ingredients.

Customer satisfaction

70 High impact

The supplied average and volume indicate strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

83 Highest impact

Broad dosing and a substantial vitamin C amount support the modest cost. The formula provides strong nutrient quantity per serving for its cost.

Report analysis

Goals

General Health
General Health
Impact
High effect
B Goal FitB- Strength of SupportC+ CoverageA- Formula Quality
Folate · 666 mcg DFEVitamin B12 · 50 mcgVitamin C · 1000 mg

A full vitamin C dose and comprehensive B-complex provide meaningful support for antioxidant defenses and energy metabolism. The focused formula clearly discloses each nutrient and avoids a proprietary blend.

Vitamin C is unbuffered, folate and B12 use conventional forms, and the product does not address minerals, fat-soluble vitamins, or essential fats. It works as focused B-plus-C support rather than a complete general-health foundation.

Study evidence
Folate Supportive 80 studies
Vitamin C Supportive 56 studies
Energy
Energy
Impact
High effect
A- Goal FitB- Strength of SupportC CoverageC Formula Quality
Vitamin B5 · 50 mgRiboflavin · 50 mgThiamin · 50 mgVitamin B12 · 50 mcg

Substantial B vitamins support cellular energy metabolism, while vitamin C adds antioxidant and deficiency coverage. The main nutrient amounts are clearly declared.

Vitamin B12 remains modest for targeted energy support, and pyridoxine plus cyanocobalamin are conventional forms. Several tiny bioflavonoid and amino-acid additions add label complexity without a meaningful energy role.

Immunity
Immunity
Impact
High effect
C+ Goal FitB+ Strength of SupportD+ CoverageC+ Formula Quality
Vitamin C · 1000 mg

A substantial vitamin C amount gives this B-complex a clear antioxidant and immune-support role. The formula lacks zinc, vitamin D, vitamin A, and selenium, so support remains concentrated in one pathway.

Bioflavonoids and rose hips are present only in small amounts and do not add much demonstrated depth. It can complement an otherwise adequate diet but is not a broad immune formula.

Study evidence
Vitamin C Supportive 53 studies
Skin Health
Skin Health
Impact
High effect
C+ Goal FitC+ Strength of SupportC- CoverageC Formula Quality
Vitamin C · 1000 mg

Vitamin C directly supports collagen synthesis and antioxidant defense, while the B-complex adds several maintenance cofactors. The product is useful for one important skin pathway but is not a complete skin-health formula.

The vitamin C amount is substantial and clearly disclosed, yet ordinary unbuffered ascorbic acid offers no enhanced absorption or stomach-comfort feature. Missing zinc, copper, vitamin E, structural actives, and hydration ingredients leaves the formula narrow.

Study evidence
Vitamin C Supportive 53 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
C- Goal FitB- Strength of SupportC- CoverageB- Formula Quality
Biotin · 50 mcgNiacin · 50 mgVitamin B12 · 50 mcgRiboflavin · 50 mgThiamin · 50 mgVitamin B5 · 50 mgVitamin B6 · 50 mg

High-dose B vitamins provide the cofactors needed to convert food into cellular energy. They do not directly stimulate thermogenesis, thyroid activity, or glucose control when nutritional status is already adequate.

The formula is focused and clearly dosed, but most vitamins use standard rather than active coenzyme forms. Daily long-term use of 50 mg vitamin B6 may cause tingling, numbness, or other nerve symptoms.

Study evidence
Niacin Supportive 17 studies
Riboflavin Mixed 5 studies
Vitamin B6 Supportive 16 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Moderate effect
D+ Goal FitB- Strength of SupportC- CoverageB Formula Quality
Vitamin C · 1000 mg

A high vitamin C amount provides focused antioxidant support that may help moderate oxidative inflammatory stress. The formula does not directly target COX, LOX, or cytokine signaling.

The dose is clear and substantial, but unbuffered ascorbic acid has no absorption or tolerance advantage. A focused B-and-C design provides depth without much unnecessary padding.

Study evidence
Rutin Supportive 6 studies
Vitamin C Supportive 50 studies
Detoxification
Detoxification
Impact
Moderate effect
D+ Goal FitC- Strength of SupportD- CoverageB- Formula Quality
Folate · 666 mcg DFEVitamin B12 · 50 mcgVitamin B6 · 50 mgVitamin C · 1000 mgCholine · 21 mgRiboflavin · 50 mg

High vitamin C and broad B vitamins support antioxidant recycling and methylation-related metabolism. Small amounts of betaine and glutamic acid do not provide robust Phase II or glutathione support.

The label clearly discloses amounts, but folate and several B vitamins use basic precursor forms. The focused vitamin formula lacks mineral cofactors, liver botanicals, and digestive elimination support.

Study evidence
Folate Supportive 16 studies
Glutamic Acid Adverse 1 study
Vitamin C Supportive 9 studies

Ingredients

IngredientAmount per serving
Vitamin C (L-Ascorbic Acid)
 1000 mg
Thiamine (Thiamine Mononitrate, Vitamin B1)
 50 mg
Riboflavin (Vitamin B2)
 50 mg
Niacin (Niacinamide, Vitamin B3)
 50 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 50 mg
Folate
666 mcg DFE
Vitamin B12 (Cyanocobalamin)
 50 mcg
Biotin (D-Biotin)
 50 mcg
Pantothenic Acid (D-Calcium Pantothenate, Vitamin B5)
 50 mg
Choline (Choline Bitartrate)
 21 mg
Inositol
50 mg
Citrus Bioflavonoid Complex
25 mg
Rose Hips
25 mg
Hesperidin
5 mg
Rutin
5 mg
Betaine (Betaine HCl)
 15 mg
L-Glutamic Acid
15 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
Vitamin B6 (Pyridoxine Hydrochloride) · 50 mg OverallScore86
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The formula supplies 50 mg of pyridoxine hydrochloride with riboflavin to support conversion to active B6. The dose fits the preferred range, and the one-tablet serving is clearly labeled. The serving cost is low for a B-complex formula.

View ingredientView products
Thiamin (Thiamine Mononitrate, Vitamin B1) · 50 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

Thiamine mononitrate is clearly disclosed at the low end of the preferred high-potency range. The tablet uses a conventional delivery format, while the serving cost is less attractive relative to the active thiamin amount. The substantial pyridoxine and vitamin C amounts may cause nerve symptoms with prolonged use or digestive discomfort in sensitive users.

View ingredientView products
Riboflavin (Vitamin B2) · 50 mg OverallScore74
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 50 mg amount is in the high-potency range for metabolic support, although standard riboflavin requires conversion to its active coenzyme form. The tablet may release more slowly than a capsule or powder. The dose-for-cost balance is especially favorable.

View ingredientView products
Loading alternative details
80 Performance

B-100 Complex with B2 Coenzyme

Nature's Way
<p>Active riboflavin and partial P-5-P provide more refined forms than the original’s conventional riboflavin and pyridoxine. The much higher B-vitamin amounts remain a drawback, and the listed vitamin B6 total deserves caution with prolonged use.</p>
79 Performance

B Complex Plus

Seeking Health
<p>Active riboflavin, vitamin B6, and vitamin B12 forms improve form quality while keeping broad B-vitamin coverage. The niacin declaration is ambiguous and the formula does not replace the original’s vitamin C, so the upgrade is mainly in B-vitamin form quality.</p>
74 Performance

Stress B-Complex

Thorne
<p>Methylcobalamin, choline citrate, and substantial pantothenic acid create a more coherent stress-focused B-complex. High vitamin B6 and niacin still limit routine use, and vitamin C is not included.</p>
77 Budget

B-50

NOW
<p>The large supply gives similar 50 mg B-vitamin coverage at a lower serving cost. It omits the original’s vitamin C and still uses basic forms with a high vitamin B6 amount, so it fits users seeking a simpler B-complex rather than the same full formula.</p>
80 Budget

B-Complex '100'

Solgar
<p>The broad B-complex costs less per serving and raises most B vitamins to 100 mg. It leaves out vitamin C and makes the already aggressive dosing issue more pronounced, especially for long-term vitamin B6 exposure.</p>
76 Budget

Hi Potency B Complex

Natural Factors
<p>The 50 mg B-vitamin pattern closely resembles the original while offering stronger serving value. It lacks vitamin C, and its high folate and vitamin B6 amounts make routine unsupervised use less balanced.</p>
77 Value

B-50 Complex 50 mg

Source Naturals
<p>The similar 50 mg B-vitamin profile and higher choline amount provide close coverage with favorable serving value. High folate and vitamin B6 remain meaningful trade-offs, and the formula does not include vitamin C.</p>
76 Value

B-Complex with Vitamin C Stress Formula

Solgar
<p>Vitamin C and a broad B-complex preserve the original’s main nutrient strategy while using more moderate thiamin, riboflavin, and vitamin B6 amounts. Conventional forms and an undefined herbal blend limit refinement, but the larger supply improves practical value.</p>
77 Value

Stress B-Complex

Bluebonnet
<p>Vitamin C, broad B-vitamin coverage, choline, and inositol make this a close functional match with a larger package. The formula remains aggressively dosed, particularly for vitamin B6, so its value advantage does not remove the long-term-use concern.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses.
    Xu K; Peng R; Zou Y; Jiang X; Sun Q; Song C · International journal of food sciences and nutrition · 2022
    Meta-analysis76 studies pooledGeneral Health forVitamin C
  2. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forVitamin C
  3. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial.
    Bazyar H; Moradi L; Zaman F; Zare Javid A · Phytotherapy research : PTR · 2023
    Randomized trial50 participantsAnti-Inflammatory Support forRutin
  4. Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature.
    Muvhulawa N; Dludla PV; Ziqubu K; Mthembu SXH; Mthiyane F; Nkambule BB; Mazibuko-Mbeje SE · Pharmacological research · 2022
    Systematic reviewAnti-Inflammatory Support forRutin
  5. Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity.
    Cosco D; Failla P; Costa N; Pullano S; Fiorillo A; Mollace V; Fresta M; Paolino D · Carbohydrate polymers · 2018
    OtherAnti-Inflammatory Support forRutin
  6. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsAnti-Inflammatory Support forRutin
  7. The Impact of the Combination of Proteolytic Enzyme and Rutin on the Post-operative Management of Inflammation: A Randomized, Controlled, Double-Blind, Comparative Clinical Trial
    Rathi PC, Rathi CL, Risbud SP, Ganu GP · Cureus · 2024
    Randomized trial65 participantsAnti-Inflammatory Support forRutin
  8. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  9. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  10. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  11. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  12. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  13. Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: a randomized clinical trial.
    Asgarshirazi M; Shariat M; Sheikh M · Hepatobiliary & pancreatic diseases international : HBPD INT · 2018
    Randomized trial55 participantsDetoxification forFolate
  14. Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
    Yuan S; Chen J; Dan L; Xie Y; Sun Y; Li X; Larsson SC · The American journal of clinical nutrition · 2022
    Meta-analysis30,368 participants22 studies pooledDetoxification forFolate
  15. Serum folate levels and urinary arsenic methylation profiles in the US population: NHANES, 2003-2012.
    Zhang X; Xu X; Zhong Y; Power MC; Taylor BD; Carrillo G · Journal of exposure science & environmental epidemiology · 2020
    Cross-sectional study11,016 participantsDetoxification forFolate
  16. Association between serum folate levels and blood concentrations of cadmium and lead in US adults.
    Wu Z; Hu H; Wang C; Wu J; Xiong Y; Fu Y; Cheng X; Su H; Li P · Environmental science and pollution research international · 2022
    Cross-sectional study15,501 participantsDetoxification forFolate
  17. Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
    Molaqanbari MR; Zarringol S; Talari HR; Taghizadeh M; Bahmani F; Mohtashamian A; Ebrahimzadeh A; Sharifi N · Advanced biomedical research · 2023
    Randomized trial66 participantsDetoxification forFolate
  18. Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men.
    Harada S; Takebayashi T; Kurihara A; Akiyama M; Suzuki A; Hatakeyama Y; Sugiyama D; Kuwabara K; Takeuchi A; Okamura T; Nishiwaki Y; Tanaka T; Hirayama A; Sugimoto M; Soga T; Tomita M · Environmental health and preventive medicine · 2016
    Cross-sectional study896 participantsDetoxification forGlutamic Acid
  19. Vitamin C supplementation ameliorates liver function profile and antiviral treatment response in Hepatitis C patients.
    Nayila I; Javed MS; Khan MA; Hussain G; Raza Naqvi SA; Ali S; Jabeen Z; Shahnawaz S; Akram R; Iman T; Hassan Dogar MZ; Malik SA · Pakistan journal of pharmaceutical sciences · 2022
    Non-randomized trial200 participantsDetoxification forVitamin C
  20. Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress.
    Alleva R; Di Donato F; Strafella E; Staffolani S; Nocchi L; Borghi B; Pignotti E; Santarelli L; Tomasetti M · The British journal of nutrition · 2012
    Non-randomized trial46 participantsDetoxification forVitamin C
  21. Dietary Vitamin C Intake Is Associated With Improved Liver Function and Glucose Metabolism in Chinese Adults.
    Luo X; Zhang W; He Z; Yang H; Gao J; Wu P; Ma ZF · Frontiers in nutrition · 2022
    Observational study8,307 participantsDetoxification forVitamin C
  22. Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection.
    Trepanier LA; Yoder AR; Bajad S; Beckwith MD; Bellehumeur JL; Graziano FM · Journal of acquired immune deficiency syndromes (1999) · 2005
    Observational studyDetoxification forVitamin C
  23. Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso.
    Lavergne SN; Kurian JR; Bajad SU; Maki JE; Yoder AR; Guzinski MV; Graziano FM; Trepanier LA · Toxicology · 2006
    Clinical trial53 participantsDetoxification forVitamin C
  24. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  25. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  26. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  27. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  28. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  29. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  30. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  31. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  32. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  33. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  34. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  35. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  36. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  37. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  38. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  39. Niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Boost forNiacin
  40. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
    Fangmann D; Theismann EM; Türk K; Schulte DM; Relling I; Hartmann K; Keppler JK; Knipp JR; Rehman A; Heinsen FA; Franke A; Lenk L; Freitag-Wolf S; Appel E; Gorb S; Brenner C; Seegert D; Waetzig GH; Rosenstiel P; Schreiber S; Schwarz K; Laudes M · Diabetes care · 2018
    Clinical trialMetabolism Boost forNiacin
  41. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.
    Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frézal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B · Nature metabolism · 2026
    Randomized trial65 participantsMetabolism Boost forNiacin
  42. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance.
    Linke A; Sonnabend M; Fasshauer M; Höllriegel R; Schuler G; Niebauer J; Stumvoll M; Blüher M · Atherosclerosis · 2009
    Randomized trial30 participantsMetabolism Boost forNiacin
  43. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
    Vaag A; Skött P; Damsbo P; Gall MA; Richter EA; Beck-Nielsen H · The Journal of clinical investigation · 1991
    Clinical trial12 participantsMetabolism Boost forNiacin
  44. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  45. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  46. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  47. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  48. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledMetabolism Boost forRiboflavin
  49. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  50. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  51. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  52. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  53. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6
  54. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  55. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  56. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  57. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  58. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C