PlusOne

PlusOne

Metagenics4.8 (86 ratings)
Format:Pack Quantity: 30 Packet(s) · 30 servings
Goals
$89.95 $2.99 per serving

About this product

The combination is most relevant when several nutritional needs overlap, particularly iron, choline and omega-3 intake. Iron, folate and B12 support normal blood formation, while the wider vitamin mix supports metabolism and immune function. Extra energy or productivity benefits are not established when nutritional needs are already met.

The 30 mg iron amount and bisglycinate form are clearly identified, with favorable absorption and tolerance characteristics. The substantial 450 mg choline contribution is a meaningful distinction from low-choline multivitamins. Zinc is paired with a known copper amount, although zinc in the same serving may compete with iron absorption.

The declared EPA and DHA provide a meaningful omega-3 contribution, but their molecular forms and concentration are unresolved. No qualifying purity-testing claim is recorded, and conflicting DHA records limit confidence in some of the supplied goal findings. The declared amounts and preparations do not establish the triglyceride effects of specific higher-exposure purified regimens or consistent cognitive enhancement.

Breadth brings a high serving cost and makes nutritional fit especially important. Vitamin D supports bone nutrition, but calcium is absent, and K1 does not inherit MK-7-specific findings. The mixture proportions for some vitamins are also missing, so the packet is harder to assess than its long ingredient list suggests.

Who is it for
  • Adults with a confirmed iron need who also want substantial choline and broad nutrient coverage.
  • People seeking combined micronutrient and omega-3 intake and willing to accept incomplete omega-3 details.
Best for
  • Covering overlapping iron, choline and micronutrient needs.
  • Supporting normal blood formation when nutrient intake or status is low.

Pros

  • Iron bisglycinate offers favorable absorption and tolerance characteristics.
  • The choline amount is substantial rather than a minor addition.
  • Both zinc and copper amounts are disclosed.
  • EPA and DHA amounts are individually declared.

Cons

  • High serving cost is difficult to justify for a single nutritional need.
  • Omega-3 molecular form, concentration and qualifying purity testing are unconfirmed.
  • Conflicting DHA records limit interpretation of some benefit findings.
  • Some vitamin-mixture proportions are undisclosed.
  • Calcium is absent despite the bone-nutrition positioning.

Warnings

  • The 30 mg iron serving makes iron need an important selection factor; a general goal of more energy does not establish that need.
  • Zinc is included with iron and may compete with its absorption, even though vitamin C, B12 and folate are also present.

Product analysis

50 out of 100

PlusOne provides broad vitamin and mineral support for dietary gaps, including nutrients involved in normal immune function and energy use. Several mixtures leave their proportions unclear, making the formula harder to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality49

Some mineral forms are favorable, including zinc citrate and potassium iodide. Other forms are unnamed or cannot be confidently compared, so quality varies across the formula.

Ingredient Transparency71

Nutrient amounts are stated, but several forms and mixture proportions are missing. You can check the quantities more easily than the exact makeup of every ingredient.

Value For Money28

The price is difficult to justify for several of the nutrient amounts supplied. Some ingredients cannot be confidently compared for value, leaving the full picture uncertain.

Customer Satisfaction73

The available ratings show very positive customer feedback. The smaller review pool gives less reassurance than a much more widely reviewed product.

Product Focus28

The formula covers many nutritional needs rather than concentrating on one purpose. Benefits are most plausible when it fills dietary gaps, and the long ingredient list makes targeted selection harder.

Format
Pack
Container
30 Packet(s)
Per serving
$2.99
Customer rating
4.8 · 86 ratings
Report analysis

Goals

Immunity
Impact
Highest effect
C Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 250 mgZinc · 25 mgVitamin A · 1650 mcgVitamin D · 25 mcgSelenium · 200 mcg

Vitamin A supports protective barriers, while zinc and vitamin D contribute to normal immune regulation. Vitamin C supports immune-cell activity and has modest cold-duration evidence with regular use; selenium supports normal immune function and antioxidant processes. Copper, iron, B6, B12 and folate help when intake is low, with no established extra benefit from larger amounts. Vitamin E receives a saved contribution, but its supplied context does not establish routine respiratory benefit.

How this product is rated for Immunity

Ingredient fit62

The relevant ingredients have a connection to immune support, with the strength of their amount findings varying by nutrient.
Goal fit
The formula includes relevant immune ingredients alongside ingredients aimed at other uses, which makes its immune focus less concentrated.
Dose adequacy
The declared amounts provide partial coverage of the saved comparisons; unresolved amounts cannot establish a contribution.

Pathways100

The strongest saved connection is barrier and antimicrobial defense.
Depth
The strongest saved connection is barrier and antimicrobial defense.
Breadth
The saved findings span barrier protection, immune-cell activity, immune regulation and antioxidant balance.

Evidence100

The main support concerns normal nutrient functions, with any respiratory benefit limited to the specific evidence described above.
Evidence strength
Vitamin C leads the saved evidence finding; normal immune function does not itself establish infection prevention.
Studied preparation
The saved findings accept the relevant preparations; this does not imply that one nutrient form gives greater immune benefit.

Formulation logic100

The recognized ingredients meet the partner checks, and no configured conflict was found. Amount uncertainties still limit ingredients whose quantities are unresolved.
Partner coverage
The recognized ingredients do not require an additional partner for the roles considered here.
Conflicts
No configured ingredient conflict was identified from the available facts; this does not establish overall safety.
Effective doses
The recognized ingredients reach the saved amount threshold; that threshold is a comparison point, not proof of clinical effectiveness.
Study evidence
Iron Supportive 23 studies
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
Impact
Highest effect
B Ingredient FitA+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 1665 mcg DFEVitamin B12 · 800 mcgVitamin D · 25 mcgVitamin K · 90 mcgSelenium · 200 mcgZinc · 25 mgVitamin C · 250 mg

B vitamins and folate contribute to energy metabolism and blood formation, with iron helping when intake is insufficient. Vitamin D and K support bone nutrition, while zinc, selenium and vitamin C contribute to normal immune and antioxidant functions. Iodine can fill a dietary gap important to thyroid health. These nutritional roles do not imply additional health improvements from the larger amounts when intake is adequate.

How this product is rated for Everyday Health

Ingredient fit78

The formula includes relevant nutrients alongside ingredients aimed at other purposes. The contributing amounts vary, with some falling below the upper comparisons used in the saved result.
Goal fit
The formula includes relevant nutrients alongside ingredients aimed at other purposes.
Dose adequacy
The contributing amounts vary, with some falling below the upper comparisons used in the saved result.

Pathways100

The strongest recorded contribution concerns energy metabolism, with the breadth finding covering energy metabolism, blood formation and folate metabolism, bone and mineral functions, antioxidant and immune functions.
Depth
The strongest recorded contribution concerns energy metabolism.
Breadth
The recorded contributions extend to energy metabolism, blood formation and folate metabolism, bone and mineral functions, antioxidant and immune functions.

Evidence82

Vitamin B9 (Folate) leads the saved evidence finding. Preparation eligibility does not establish extra benefit beyond the supplied context.
Evidence strength
Vitamin B9 (Folate) provides the strongest eligible contribution; the supported health claim remains limited by its supplied nutritional or population context.
Studied preparation
The eligible contributing preparations match the saved preparation criteria; this does not establish superiority over other forms.

Formulation logic100

The contributing ingredients work independently or have their required partners present. No configured ingredient conflict was found in the supplied facts.
Partner coverage
The contributing ingredients work independently or have their required partners present.
Conflicts
No configured ingredient conflict was found in the supplied facts.
Effective doses
All ingredients retained for this finding meet its minimum amount comparison; this does not make every listed ingredient effective.
Study evidence
Folate Supportive 80 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Zinc Supportive 60 studies
Impact
Highest effect
C Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Zinc · 25 mgVitamin E · 100.3 mgVitamin C · 250 mgCopper · 2 mgVitamin A · 1650 mcgEPA (Eicosapentaenoic Acid) · 670 mg

Lutein contributes to macular pigment and has limited evidence for selected contrast and glare outcomes, without a consistent improvement in visual acuity. Vitamin A supports the visual cycle and can address night-vision problems caused by deficiency. Other nutrients in the formula have normal biological roles, but evidence from defined AMD regimens does not establish general vision improvement from this product.

How this product is rated for Eye Health

Ingredient fit61

Relevant ingredients form part of a broader formula with additional actives. Partial or unresolved quantities limit the comparison; the anchors are not proven effective vision doses.
Goal fit
Relevant ingredients form part of a broader formula with additional actives.
Dose adequacy
Partial or unresolved quantities limit the comparison; the anchors are not proven effective vision doses.

Pathways100

Retinal and lens antioxidant defense is the strongest recorded area; this describes the ingredient roles rather than a demonstrated clinical outcome.
Depth
Retinal and lens antioxidant defense is the strongest recorded area; this describes the ingredient roles rather than a demonstrated clinical outcome.
Breadth
Macular pigment, antioxidant defense and the visual cycle reach the coverage threshold.

Evidence99

Lutein leads the eligible evidence findings, with the limitations of its specific population and outcomes still applying.
Evidence strength
Lutein leads the eligible evidence findings, with the limitations of its specific population and outcomes still applying.
Studied preparation
Most eligible preparations match the supplied comparisons; DHA lacks a studied-preparation match.

Formulation logic100

No configured ingredient conflict was found. All retained ingredients meet the minimum amount threshold, which is not a proven effective vision dose.
Partner coverage
The retained ingredients have no unmet partner requirement in the supplied findings.
Conflicts
No configured ingredient conflict was found.
Effective doses
All retained ingredients meet the minimum amount threshold, which is not a proven effective vision dose.
Study evidence
Copper Supportive 7 studies
Riboflavin Supportive 69 studies
Selenium Supportive 15 studies
Vitamin A Supportive 65 studies
Vitamin C Disputed 24 studies
Vitamin D Disputed 35 studies
Vitamin E Disputed 35 studies
Zinc Supportive 39 studies
Cardiovascular Support
Impact
Highest effect
C Ingredient FitA+ PathwaysB+ EvidenceA+ Formulation Logic
Vitamin K · 90 mcgVitamin D · 25 mcgL-Carnitine · 500 mgSelenium · 200 mcgVitamin B12 · 800 mcgVitamin B6 · 20 mgVitamin E · 100.3 mgFolate · 1665 mcg DFENiacin · 35 mgVitamin C · 250 mg

EPA and DHA have a connection to triglyceride lowering, although the supplied component studies used specific purified preparations at higher daily exposures. Folate, vitamin B6 and B12 support homocysteine metabolism, but lowering that marker does not automatically reduce cardiovascular events. Thiamin and selenium can address heart problems caused by deficiency; extra intake has no established cardiovascular advantage when status is adequate. Broad nutrient coverage does not establish broad prevention.

How this product is rated for Cardiovascular Support

Ingredient fit65

EPA declared active is a key ingredient in the saved cardiovascular-related findings. Support from the disclosed amounts is uneven.
Goal fit
The cardiovascular-related ingredients sit within a broader formula that includes ingredients serving other purposes.
Dose adequacy
The disclosed amounts give uneven support, with partial or unknown amounts limiting some ingredient contributions.

Pathways100

The strongest coverage concerns triglyceride metabolism. The breadth finding includes triglyceride metabolism, antioxidant-related functions, homocysteine metabolism.
Depth
The strongest saved coverage concerns triglyceride metabolism; this does not establish a clinical outcome.
Breadth
The routes meeting the breadth criterion are triglyceride metabolism, antioxidant-related functions, homocysteine metabolism. Other routes receive less or no coverage.

Evidence83

EPA and DHA support triglyceride-related findings; the trials used specific purified preparations, and marker changes do not establish event prevention.
Evidence strength
EPA and DHA support triglyceride-related findings; the trials used specific purified preparations, and marker changes do not establish event prevention.
Studied preparation
The saved preparation criteria are met, while the supplied fatty-acid trials retain preparation and population distinctions.

Formulation logic100

The credited ingredients meet the minimum amount criterion, with no unmet partner requirement or evaluated ingredient conflict identified.
Partner coverage
No credited ingredient has an unmet partner requirement; this does not establish extra benefit from combining ingredients.
Conflicts
No ingredient conflict was identified by the evaluated rules.
Effective doses
All credited ingredients meet the saved minimum amount criterion, which is not a proven effective dose or benefit threshold.
Study evidence
Folate Supportive 93 studies
Niacin Supportive 136 studies
Selenium Supportive 107 studies
Vitamin B6 Supportive 35 studies
Vitamin C Supportive 101 studies
Vitamin D Mixed 170 studies
Vitamin E Mixed 79 studies
Vitamin K Supportive 40 studies
Impact
High effect
C- Ingredient FitB+ PathwaysA+ EvidenceA+ Formulation Logic
Vitamin K · 90 mcgEPA (Eicosapentaenoic Acid) · 670 mgVitamin B12 · 800 mcgVitamin B6 · 20 mgFolate · 1665 mcg DFEVitamin D · 25 mcg

EPA is relevant to triglyceride support, while folate and vitamins B6 and B12 contribute to homocysteine metabolism. Neither routine omega-3 supplementation nor homocysteine lowering establishes general prevention of major cardiac events. The separate DHA heart-health profile remains unresolved despite a retained catalogue declaration, so no additional DHA contribution is established. L-carnitine clinical findings also do not establish routine prevention.

How this product is rated for Heart Health

Ingredient fit58

The relevant ingredients sit within a broader formula linked to other goals. The counted amounts receive partial recognition overall, without establishing a clinically effective prevention regimen.
Goal fit
The relevant ingredients sit within a broader formula linked to other goals.
Dose adequacy
The counted amounts receive partial recognition overall, without establishing a clinically effective prevention regimen.

Pathways80

Homocysteine metabolism is the strongest contributing pathway; the biochemical finding does not establish cardiovascular-event prevention. Two evaluated pathways meet the breadth threshold.
Depth
Homocysteine metabolism is the strongest contributing pathway; the biochemical finding does not establish cardiovascular-event prevention.
Breadth
Two evaluated pathways meet the breadth threshold.

Evidence100

EPA (Eicosapentaenoic Acid) leads the saved finding. The counted preparations receive recognition, without proving the same population, duration or clinical outcome.
Evidence strength
EPA (Eicosapentaenoic Acid) leads the saved evidence finding; clinical interpretation remains specific to the ingredient and outcome.
Studied preparation
The counted preparations receive recognition, without proving the same population, duration or clinical outcome.

Formulation logic100

Each counted ingredient works independently or has its required partner; no extra combined benefit is established. No configured conflict was matched.
Partner coverage
Each counted ingredient works independently or has its required partner; no extra combined benefit is established.
Conflicts
No configured ingredient conflict was matched.
Effective doses
Counted ingredients meet the inclusion criterion; other relevant declared ingredients remain below it or unresolved.
Study evidence
Folate Supportive 116 studies
Niacin Supportive 105 studies
Selenium Mixed 89 studies
Vitamin B6 Supportive 44 studies
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Impact
Highest effect
C+ Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Choline · 450 mgThiamin · 3.4 mgVitamin B6 · 20 mgFolate · 1665 mcg DFEVitamin B12 · 800 mcgVitamin D · 25 mcgEPA (Eicosapentaenoic Acid) · 670 mg

DHA has a narrow learning and memory role supported mainly in older adults with age-associated memory weakness; findings are mixed across older populations. Thiamin, niacin, folate, B12 and iron can help when low intake or deficiency impairs cognition. Choline supports acetylcholine production, but generic choline has not consistently improved memory in healthy adults. The separately confirmed DHA declaration supports its presence despite an unresolved legacy ingredient record.

How this product is rated for Cognitive Support

Ingredient fit66

Cognitive ingredients sit within a broader formula containing ingredients aimed at other uses. Most counted amounts approach the comparison amounts, without establishing that they reproduce trial benefits.
Goal fit
Cognitive ingredients sit within a broader formula containing ingredients aimed at other uses.
Dose adequacy
Most counted amounts approach the comparison amounts, without establishing that they reproduce trial benefits.

Pathways100

The strongest assigned connection concerns oxidative and inflammatory protection, without proving improved cognitive performance. Three mechanisms reach the required coverage level; this describes ingredient connections rather than the breadth of proven benefits.
Depth
The strongest assigned connection concerns oxidative and inflammatory protection, without proving improved cognitive performance.
Breadth
Three mechanisms reach the required coverage level; this describes ingredient connections rather than the breadth of proven benefits.

Evidence100

Vitamin B6 leads the saved evidence comparison, but its specific population and outcome limitations still apply.
Evidence strength
Vitamin B6 leads the saved evidence comparison, but its specific population and outcome limitations still apply.
Studied preparation
The counted preparations were treated as matching the comparison; this does not remove the ingredient-specific evidence limitations.

Formulation logic100

The counted ingredients meet the partner and minimum-amount comparisons, and no configured conflict was identified. These findings do not establish combination benefits.
Partner coverage
No counted ingredient was missing a required partner; this does not establish an added benefit from combining ingredients.
Conflicts
No configured ingredient conflict was identified from the supplied facts.
Effective doses
All counted ingredients exceed the minimum comparison amount, which is not a proven effective-dose threshold.
Study evidence
Choline Supportive 76 studies
Folate Supportive 68 studies
Thiamin Supportive 30 studies
Vitamin B6 Supportive 17 studies
Vitamin D Supportive 118 studies
Zinc Supportive 48 studies

Ingredients

IngredientAmount per servingScore
Calories
25 Calorie(s)
Total Fat
3 Gram(s)
Cholesterol
5 mg
Vitamin A (Mixed Carotenoids, Retinyl Palmitate)
1650 mcg
Vitamin C (Ascorbic Acid, Niacinamide Ascorbate)
250 mg
Vitamin D (Cholecalciferol)
25 mcg
Vitamin E (D-Alpha-Tocopheryl Succinate, Mixed Tocopherols)
100.3 mg
Vitamin K (Phytonadione)
90 mcg 22
Thiamine (Thiamine Mononitrate)
3.4 mg
Riboflavin
3.4 mg
Niacin (Niacinamide Ascorbate)
35 mg 54
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
20 mg 68
Folate (Calcium L-5-Methyltetrahydrofolate)
1665 mcg DFE
Vitamin B12 (Methylcobalamin)
800 mcg 76
Biotin
300 mcg 59
Pantothenic Acid (Calcium D-Pantothenate)
20 mg 61
Choline (Choline Bitartrate)
450 mg 71
Iron (Ferrous Bis-Glycinate)
30 mg 69
Iodine (Potassium Iodide)
176 mcg 84
Zinc (Zinc Citrate)
25 mg 77
Selenium (Selenomethionine)
200 mcg 63
Copper (Copper Citrate)
2 mg 76
Manganese (Manganese Citrate)
2 mg 70
Chromium (Chromium Citrate)
200 mcg 47
Molybdenum (Molybdenum Aspartate Complex)
25 mcg 44
Docosahexaenoic Acid
1 Gram(s)
Eicosapentaenoic Acid
670 mg 35
L-Carnitine (L-Carnitine L-Tartrate)
500 mg 62
Lutein
6 mg
Zeaxanthin
2 mg
Gluten Free Pregnant Women 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving provides 176 mcg iodine from potassium iodide. A whole-product serving costs about $3.00.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The iodine comes from potassium iodide, a form regarded favorably in the evaluation.
Iodine Form & Bioavailability
Potassium iodide is the identified iodine form, which the evaluation regards favorably.
Marine Source Purity & Sourcing
No marine source is recorded in the saved facts, so the evaluation does not flag seaweed sourcing for this iodine.

Dose, Safety & Label Transparency100

The iodine amount is specified at 176 mcg per serving. The evaluation does not flag it as above its safety limit.
Dosage Efficacy for Daily Support
A serving provides 176 mcg iodine.
Dosage Safety & Upper Limits
The evaluation does not flag the 176 mcg of iodine in a serving as above its safety limit.
Elemental Iodine Transparency
The saved facts state an iodine amount of 176 mcg per serving.

Value20

A whole-product serving costs about $3.00, on the higher side in the evaluation.
Price Per Effective Serving
A whole-product serving costs about $3.00, on the higher side in the evaluation.
A+ Ingredient Form & Label QualityC Dose, Safety & Label TransparencyF Value
+1
Each serving provides 20 mg of vitamin B6, exceeding the European adult daily upper limit on its own. B6 from food and other supplements adds to total intake.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 comes from pyridoxal 5-phosphate and pyridoxine hydrochloride, with their relative amounts unknown.
Vitamin B6 Form Identification
The named B6 sources are pyridoxal 5-phosphate and pyridoxine hydrochloride; their relative amounts are not disclosed in the saved facts.
Clean Label and Excipient Purity
No listed additive concerns were flagged in the evaluation; that does not establish an additive-free formula.

Dose, Safety & Label Transparency65

The 20 mg of B6 per serving exceeds the European adult daily upper limit on its own; food and other supplements add to total intake.
Vitamin B6 Dose & Safety Policy
Each serving has 20 mg of vitamin B6, exceeding the European adult daily upper limit on its own. Other sources add to total intake.
Label Transparency
The B6 source is identified as pyridoxal 5-phosphate and pyridoxine hydrochloride.

Value11

Based on the whole-product price, the cost is about $0.15 per mg of vitamin B6, which is high on that basis.
Vitamin B6 Price Efficiency
Based on the whole-product price, the cost is about $0.15 per mg of vitamin B6, which is high on that basis.
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving provides 450 mg of choline from Choline Bitartrate, with high cost for the choline provided. The Other Ingredients list includes a flow agent and no flagged artificial additives.
How this ingredient is rated

Active Ingredient Quality & Bioavailability68

Choline Bitartrate is a standard form used for systemic choline support. The Other Ingredients list includes a flow agent and no flagged artificial additives.
Choline Form Efficacy & Bioavailability
Choline Bitartrate is a standard choline form used for systemic support.
Formula Purity & Excipient Quality
The Other Ingredients list includes a flow agent and no flagged artificial additives.

Dose, Safety & Label Transparency100

The serving provides 450 mg of choline, and its source is stated.
Choline Dose by Declared Basis
Each serving provides 450 mg of choline.
Elemental Yield Transparency
The choline amount and its Choline Bitartrate source are stated.

Value20

The cost for the amount of choline is high.
Price per 100 mg of Declared Choline Basis
The cost for the amount of choline is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  2. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  3. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  4. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  5. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  6. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  7. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsBone Health forFolate
  8. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate Bone Health forVitamin B6
  9. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsBone Health forFolate
  10. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsBone Health forFolate
  11. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  12. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  13. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  14. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  15. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  16. Evaluating the Protective Role of Vitamin A Supplementation in Periodontal Health: A Comprehensive Systematic Review and Meta-Analysis.
    Luca MM; Buzatu R; Bumbu BA · Journal of clinical medicine · 2024
    Meta-analysisBone Health forVitamin A
  17. Dietary vitamin A intake and bone health in the elderly: the Rotterdam Study.
    de Jonge EA; Kiefte-de Jong JC; Campos-Obando N; Booij L; Franco OH; Hofman A; Uitterlinden AG; Rivadeneira F; Zillikens MC · European journal of clinical nutrition · 2016
    Cohort study5,288 participantsBone Health forVitamin A
  18. Vitamin A and its dervatives effect on bone mineral density, a systematic review.
    Khojah Q; AlRumaihi S; AlRajeh G; Aburas A; AlOthman A; Ferwana M · Journal of family medicine and primary care · 2022
    Systematic review8 studies pooledBone Health forVitamin A
  19. Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study.
    Wang Q; Yu H; Kong Y · BMC musculoskeletal disorders · 2024
    Cross-sectional study1,536 participantsBone Health forVitamin A
  20. Association of dietary consumption and serum levels of vitamin A and β-carotene with bone mineral density in Chinese adults.
    Chen GD; Zhu YY; Cao Y; Liu J; Shi WQ; Liu ZM; Chen YM · Bone · 2016
    Cohort study3,154 participantsBone Health forVitamin A