Vitamin B5
Pantothenic acid, commonly known as Vitamin B5, is a crucial water-soluble B vitamin. It plays a central role in numerous metabolic pathways, primarily as a component of coenzyme A (CoA). CoA is vital for the synthesis and breakdown of fats, carbohydrates, and proteins, making B5 indispensable for energy production and nutrient utilization. Beyond its role in energy metabolism, Vitamin B5 is involved in the synthesis of steroid hormones, cholesterol, and various neurotransmitters. It also contributes to the production of red blood cells and supports the adrenal glands, which are responsible for stress response. Its broad involvement in bodily functions highlights its importance for overall health and well-being. Pantothenic acid is readily available from a wide array of food sources, and deficiencies are rare due to its widespread presence ("pantothen" comes from the Greek word "pantothen," meaning "from everywhere"). Supplementation is typically considered safe at recommended doses, with few adverse effects.
Meat (chicken, beef, liver)FishWhole grainsAvocadoMushroomsPotatoesEggsLegumesDairy productsBroccoli
Cheapest Vitamin B5 supplements
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Best Vitamin B5 supplements
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RDA (Men)5 mg
RDA (Women)5 mg
RDI5 mg
Minimum10 mg
Maximum50 mg
Toxicity Threshold10000 mg
Toxicity Effectdiarrhea, water retention
Impact
Highest effect
Typical dose:5–10 mg
Vitamin B5 (Pantothenic Acid) is central to energy production via the Krebs cycle and the breakdown of fatty acids. It's fundamental for creating ATP from all macronutrients, making it essential for sustained energy.
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Impact
Highest effect
Typical dose:5–10 mg
Pantothenic Acid is central to metabolism because as part of Coenzyme A, it is required for the oxidation of fatty acids and for the entry point into the citric acid cycle (as Acetyl-CoA). Virtually all energy-yielding pathways depend on it, establishing it as a foundational nutrient for metabolism.
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Impact
Moderate effect
Typical dose:50–250 mg
Vitamin B5 (Pantothenic Acid) is a critical component of Coenzyme A, which is essential for the synthesis of stress hormones like cortisol in the adrenal glands. Ensuring adequate levels helps the body maintain a robust and balanced response to stressors, preventing depletion during chronic stress. It is most effective as part of a B-complex.
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Impact
Situational effect
Typical dose:50–250 mg
Vitamin B5 (Pantothenic Acid) is involved in synthesizing coenzyme A, which is essential for fatty acid metabolism. This supports the skin's lipid barrier, aiding hydration and wound healing. It is particularly noted for its potential to help regulate sebum production, making it situationally useful for acne-prone skin.
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add_circle_outline Positive Interactions
Vitamin B6
B5 and B6 work together in numerous metabolic pathways, including amino acid metabolism and neurotransmitter synthesis.
Biotin
Both B5 and Biotin are B vitamins essential for metabolism, particularly of fats and carbohydrates.
Folate
As part of the B-complex, B5 works synergistically with Folate in various metabolic functions, including cell growth and repair.
Niacin
Another B vitamin that collaborates with B5 in energy production and other metabolic processes.
Riboflavin
As part of the B-complex, Riboflavin assists B5 in energy metabolism and enzyme function.
Thiamin
Essential for carbohydrate metabolism, Thiamin works with B5 and other B vitamins in converting food into energy.
Vitamin B12
All B vitamins work together; B12 is crucial for energy and nerve function, complementing B5's roles.
Choline
Choline and B5 are both involved in the synthesis of neurotransmitters and fat metabolism.
Magnesium
Magnesium is a cofactor for many enzymes involved in energy production, supporting the metabolic processes B5 facilitates.
L-Carnitine
B5 is essential for the synthesis of Coenzyme A, which is needed for fatty acid transport, a process L-Carnitine also supports.
Acetyl L-Carnitine
Similar to L-Carnitine, B5's role in CoA synthesis indirectly supports the fatty acid transport and energy production facilitated by Acetyl L-Carnitine.
Coenzyme Q-10
Both B5 (via Coenzyme A) and Coenzyme Q-10 are crucial for cellular energy production within the mitochondria.
Cysteine
Cysteine is a precursor to Coenzyme A, for which Vitamin B5 is a key component.
Glutathione
B vitamins, including B5, support liver detoxification pathways which are crucial for glutathione's antioxidant functions.
85 Value 
Pantothenic Acid 500 mg
NOW
4.7
★★★★★
(21999 ratings)
Vitamin B5: 500 mg
This Pantothenic Acid supplement delivers a standard 500 mg dose of Vitamin B5 (Calcium Pantothenate) in a convenient capsule form, suitable for daily support of energy, metabolism, and skin health.
87 Value 
Pantothenic Acid B5 500 mg
Jarrow Formulas
4.6
★★★★★
(10091 ratings)
Vitamin B5: 500 mg
This Jarrow Formulas product provides a standard 500 mg dose of Pantothenic Acid (D-Calcium Pantothenate) in vegetarian capsules, supporting metabolism, energy, and stress response.
70 Budget 
Complete Multivitamin Adults 50+
Equate
4.7
★★★★★
(2059 ratings)
Vitamin B5: 10 mg
This multivitamin for adults 50+ offers a foundational blend of essential vitamins, minerals, and key carotenoids like Lutein and Lycopene, supporting general health, bone density, and vision at a very accessible price.
68 Budget 
Daily Vits
NOW
4.7
★★★★★
(11036 ratings)
Vitamin B5: 10 mg
This multivitamin is a convenient, basic option covering fundamental vitamin needs with some well-absorbed minerals, although doses for key minerals like calcium and magnesium are quite low.
72 Budget 
B-50 Complex 50 mg
Source Naturals
4.7
★★★★★
(2645 ratings)
Vitamin B5: 100 mg
A standard B-50 complex with 50mg doses of most B vitamins, plus Choline, PABA, and Inositol, featuring a higher dose of Folic Acid, and offering exceptional value.
88 Value 
Pantothenic Acid 550 mg
Solgar
4.7
★★★★★
(1089 ratings)
Vitamin B5: 550 mg
A high-dose Vitamin B5 option at 550 mg that supports energy metabolism and general well-being.
75 Budget 
One Daily Essential
21st Century
4.7
★★★★★
(3224 ratings)
Vitamin B5: 10 mg
A very affordable, basic daily multivitamin providing essential vitamins and some calcium for general wellness support.
68 Budget 
Therapeutic-M
21st Century
4.7
★★★★★
(615 ratings)
Vitamin B5: 10 mg
Therapeutic-M is a cost-effective multivitamin-mineral supplement designed to offer broad, everyday nutritional support for general wellness.
80 Value 
Pantothenic Acid 500 mg
Swanson
4.8
★★★★★
(157 ratings)
Vitamin B5: 500 mg
This Swanson Pantothenic Acid provides a 500 mg dose of D-Calcium Pantothenate in a capsule form, suitable for long-term daily support of energy, metabolism, and skin.
85 Value 
Pantothenic Acid 500 mg
NOW
4.9
★★★★★
(45 ratings)
Vitamin B5: 500 mg
A standard 500 mg Pantothenic Acid (Calcium Pantothenate) supplement from NOW in capsule form, providing foundational support for energy, metabolism, and stress response.
80 Value 
Pantothenic Acid 250 mg
Source Naturals
4.7
★★★★★
(197 ratings)
Vitamin B5: 250 mg
This Source Naturals product delivers 250 mg of Pantothenic Acid (Calcium D-Pantothenate) in a tablet, offering long-lasting and economical support for metabolism, energy, and stress response.
79 Best 
ImmunAbreve
Advanced Nutrition by Zahler
4.7
★★★★★
(113 ratings)
Vitamin B5: 1000 mg
This product delivers a focused blend of essential vitamins in specific forms and traditional herbs, designed to support overall wellness and immune system function.
78 Best 
Abreve
Zahler
4.6
★★★★★
(2851 ratings)
Vitamin B5: 1000 mg
This product is a multi-ingredient blend featuring a strong lineup of traditional herbs and vitamins, mainly focusing on supporting general health and immune function.
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Extra Strength Hair Skin & Nails
Nature's Bounty Optimal Solutions
4.7
★★★★★
(69 ratings)
Vitamin B5: 15 mg
This supplement provides a comprehensive mix of high-dose biotin, essential vitamins, and minerals, plus supporting beauty ingredients like collagen and hyaluronic acid, all aimed at enhancing hair, skin, and nail health.
75 Budget 
One Daily Women's Health
Equate
4.7
★★★★★
(5571 ratings)
Vitamin B5: 10 mg
This multivitamin provides essential vitamins and minerals in a convenient daily tablet, formulated to help meet the general nutritional needs of women.
80 Best 
Pantothenic Acid 1000 mg
KAL
4.7
★★★★★
(895 ratings)
Vitamin B5: 1000 mg
This KAL product offers a high 1000 mg dose of Pantothenic Acid (Calcium D-Pantothenate) in tablet form, designed for intensive support of metabolism, energy, and overall cellular functions.
93 Best 
Life Extension Mix Powder
Life Extension
4.3
★★★★★
(418 ratings)
Vitamin B5: 600 mg
A highly comprehensive multi-nutrient powder packed with a vast array of vitamins, minerals, and botanical extracts for broad-spectrum wellness support, offered in a versatile powder form.
94 Best 
Life Extension Mix Tablets
Life Extension
4.7
★★★★★
(315 ratings)
Vitamin B5: 600 mg
A highly comprehensive multi-nutrient formula packed with a vast array of vitamins, minerals, and botanical extracts designed for broad-spectrum wellness support.
88 Best 
Life Extension Mix Tablets without Copper
Life Extension
4.7
★★★★★
(139 ratings)
Vitamin B5: 600 mg
This comprehensive tablet supplement provides a wide range of vitamins, chelated minerals, antioxidants, and adaptogenic herbs, offering robust, broad-spectrum nutritional support, especially for those seeking a copper-free formula.
83 Value 
Pantothenic Acid 500 mg
Solaray
4.7
★★★★★
(4448 ratings)
Vitamin B5: 500 mg
This Solaray product provides 500 mg of Pantothenic Acid (Calcium D-Pantothenate) in a VegCap, offering vegetarian-friendly support for metabolism, energy, and stress response.
78 Budget 
B-Complex plus Vitamin C
21st Century
4.7
★★★★★
(26874 ratings)
Vitamin B5: 10 mg
A budget-friendly tablet offering a full spectrum of B vitamins alongside Vitamin C and supplemental Calcium, supporting energy and general well-being.
68 Budget 
One Daily Men's Health
Equate
4.7
★★★★★
(2147 ratings)
Vitamin B5: 16 mg
This is a comprehensive and budget-friendly multivitamin for men, providing a wide array of essential vitamins and minerals for daily nutritional support.
72 Budget 
Women's One Daily
INNATE Response Formulas
4.5
★★★★★
(334 ratings)
Vitamin B5: 10 mg
An exceptionally affordable daily multivitamin for women, delivering essential vitamins and well-absorbed mineral forms, providing great value despite lacking calcium and having modest Vitamin D3 for bone health.
90 Value 
Pantothenic Acid 500 mg
Solaray
4.7
★★★★★
(4065 ratings)
Vitamin B5: 500 mg
An outstanding value option for 500 mg Vitamin B5 from Solaray, offering foundational metabolic and energy support at a highly competitive price.
78 Best 
Pantothenic Acid 1000 mg
NaturesPlus
4.7
★★★★★
(785 ratings)
Vitamin B5: 1000 mg
This NaturesPlus product delivers a high 1000 mg dose of Pantothenic Acid (Calcium Pantothenate) in tablet form, intended for intensive support of metabolism, energy, and overall cellular health.
93 Best 
Life Extension Mix Capsules
Life Extension
4.7
★★★★★
(531 ratings)
Vitamin B5: 600 mg
A highly comprehensive multi-nutrient capsule formula packed with a vast array of vitamins, minerals, and botanical extracts for broad-spectrum wellness support, offered in a convenient capsule form.
93 Best 
Life Extension Mix Tablets with Extra Niacin
Life Extension
4.7
★★★★★
(213 ratings)
Vitamin B5: 600 mg
A highly comprehensive multi-nutrient tablet formula with an extra high dose of niacin, offering extensive vitamin, mineral, and botanical support for a wide range of wellness objectives.
87 Best 
Life Extension Mix Capsules without Copper
Life Extension
4.8
★★★★★
(161 ratings)
Vitamin B5: 600 mg
This multi-ingredient capsule blend offers extensive nutritional support through vitamins, chelated minerals, antioxidants, and adaptogenic herbs, making it a comprehensive choice for general wellness for those who prefer capsules and no added copper.
83 Value 
Pantothenic Acid (Vitamin B-5) 500 mg
Life Extension
4.8
★★★★★
(2221 ratings)
Vitamin B5: 500 mg
This is a standard 500 mg Pantothenic Acid (D-Calcium Pantothenate) supplement from Life Extension in capsule form, aimed at supporting energy, metabolism, and stress response.
Average$31.41
Median$26.80
Average$0.76
Median$0.56
Average$0.37
Median$0.19
Reference amount: 10 mg
D-Calcium Pantothenate is a widely used and stable salt form of Vitamin B5, meaning the active D-pantothenic acid is bound to calcium. This form is well-absorbed in the digestive system and efficiently converted to coenzyme A, which is vital for numerous metabolic processes. It is a preferred form in many dietary supplements due to its stability and excellent bioavailability.
- Highly stable
- Excellent bioavailability
- Well-researched and widely available
- Generally well-tolerated
- Requires conversion in the body to its active form (pantothenic acid), though this process is efficient
Avg$29.05
Med$23.99
Avg$0.76
Med$0.45
Avg$0.34
Med$0.16
Price distribution
Calcium D-Pantothenate is the preferred and most common supplemental form of Vitamin B5, explicitly indicating the biologically active D-isomer bound to calcium. This combination ensures stability and optimal absorption. Once absorbed, it is readily utilized by the body to synthesize coenzyme A, which is indispensable for carbohydrate, fat, and protein metabolism, and for the synthesis of fatty acids, cholesterol, and steroid hormones.
- Highly stable with excellent bioavailability
- Explicitly contains the active D-isomer
- Well-researched and widely available
- No significant cons compared to other effective forms.
Avg$33.19
Med$29.59
Avg$0.75
Med$0.60
Avg$0.37
Med$0.19
Price distribution
Calcium Pantothenate is a common supplemental form of Vitamin B5, usually referring to D-Calcium Pantothenate. It combines pantothenic acid with calcium, enhancing stability and ease of incorporation into supplements. Upon ingestion, it releases pantothenic acid, which is then converted into coenzyme A, a key molecule for energy production and nutrient metabolism.
- Stable and widely available
- Good bioavailability
- Generally well-tolerated
- Generic term, might not always explicitly state D-isomer, though usually implies it for supplements.
Avg$33.90
Med$25.46
Avg$0.76
Med$0.48
Avg$0.26
Med$0.16
Price distribution
Vitamin B5, also known as pantothenic acid, is an essential water-soluble vitamin required for numerous metabolic functions, including the synthesis of coenzyme A (CoA). CoA is crucial for the metabolism of carbohydrates, fats, and proteins, and for the synthesis of fatty acids, cholesterol, and steroid hormones. While "Vitamin B5" refers to the nutrient itself, supplements typically contain a stable form like calcium pantothenate.
- Essential nutrient for overall health
- Involved in critical metabolic pathways
- As a general term, it doesn't specify a particular form, which can impact absorption or stability in supplements.
Avg$43.17
Med$30.98
Avg$0.77
Med$0.54
Avg$1.92
Med$0.52
Price distribution
Pantethine is a derivative of pantothenic acid that is composed of two pantetheine molecules. Pantetheine is the precursor to coenzyme A, making pantethine a more direct and often considered more metabolically active form of Vitamin B5. It is particularly known for its potential role in supporting healthy lipid profiles, as it's a key component of the acyl carrier protein (ACP) and coenzyme A, involved in fatty acid synthesis and degradation.
- Directly converts to pantetheine and then coenzyme A
- Potentially more potent for specific metabolic pathways (e.g., lipid metabolism)
- Well-absorbed
- More expensive than standard pantothenic acid forms
- May not be necessary for general B5 supplementation
Avg$28.99
Med$27.84
Avg$0.65
Med$0.68
Avg$0.58
Med$0.59
Price distribution
Pantothenic acid is the biologically active core compound of Vitamin B5. It is a water-soluble vitamin essential for life, primarily acting as a precursor to coenzyme A (CoA). CoA is critical for energy metabolism, fatty acid synthesis and breakdown, and the synthesis of neurotransmitters and hormones. While fundamental, the free acid form is less stable than its salt derivatives like calcium pantothenate, especially when exposed to heat, acid, or alkaline conditions.
- The active chemical form, essential for all B5 functions
- Less stable than salt forms, can degrade during processing or storage, potentially leading to lower potency in supplements if not properly stabilized.
Avg$26.84
Med$27.92
Avg$0.80
Med$0.85
Avg$0.53
Med$0.43
Price distribution
d-Panthenol is synonymous with D-Panthenol and dexpanthenol. It is a provitamin of B5, meaning it converts to pantothenic acid within the body or upon topical application. It is highly valued in cosmetics and skincare for its ability to hydrate, soothe, and promote tissue repair, making it effective for improving skin barrier function and overall skin health. When taken internally, it serves as a bioavailable source of Vitamin B5.
- Excellent for topical skin and hair health
- Readily converted to active B5
- Well-tolerated, effective orally
- Less common in oral supplements compared to calcium pantothenate
- Primarily known for topical applications
Avg$12.22
Med$12.22
Avg$0.73
Med$0.66
Avg$0.12
Med$0.12
Price distribution
Organic brown rice is a natural, unprocessed whole grain that contains pantothenic acid (Vitamin B5) along with other B vitamins, minerals, and dietary fiber. While it contributes to overall B5 intake as part of a balanced diet, it is not a concentrated or isolated form of Vitamin B5. Its benefits stem from the synergy of its complete nutritional profile, rather than delivering a high dose of a single nutrient.
- Natural food source of B5 and other essential nutrients
- Provides dietary fiber
- Certified organic status
- Not a concentrated source of Vitamin B5
- B5 intake levels are highly variable
- Not suitable for targeted high-dose B5 supplementation
Avg$32.65
Med$29.59
Avg$0.83
Med$0.88
Avg$0.44
Med$0.46
Price distribution