Prenatal Advanced Care Vitamins & Minerals with 5-MTHF

Prenatal Advanced Care Vitamins & Minerals with 5-MTHF

Kirkman4.8 (62 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 60 servings
Goals
$41.50 $0.69 per serving

About this product

Folate and iron give this prenatal a clear nutritional purpose. The formula supplies 27 mg iron as ferrous bisglycinate, a form favored for absorption and stomach tolerance. B vitamins and vitamin C support normal energy use, with benefits depending on nutritional need.

Zinc citrate and potassium iodide are favorable mineral choices, and the 5-MTHF folate source is named. Copper oxide is a less favorable choice for absorption. The vitamin A and riboflavin mixtures lack proportions, so those parts of the formula cannot be compared fully.

The 200 mg calcium and 100 mg magnesium contributions are limited, so dietary mineral intake still matters. The broad formula does not establish additional pregnancy-specific gains in energy, hair or metabolism. Its cost is relatively high for several individual nutrients, making the fit with the person's prenatal nutrition plan more important than the length of the ingredient list.

Who is it for
  • People seeking prenatal nutrient support that fits their individual needs
  • Those whose prenatal nutrition plan includes supplemental iron and folate
Best for
  • Prenatal nutrient coverage
  • Supporting normal blood formation
  • Filling dietary iron and folate gaps

Pros

  • Ferrous bisglycinate favors iron absorption and stomach tolerance
  • The folate source is specifically identified
  • Zinc citrate and potassium iodide are favorable forms

Cons

  • Copper oxide is less favorable for absorption
  • Calcium coverage is limited
  • Vitamin A and riboflavin proportions are undisclosed
  • Relatively high cost for several individual nutrient contributions

Warnings

  • Zinc in the same serving may compete with iron absorption, so the combination does not establish how much of the 27 mg iron will be absorbed.

Product analysis

54 out of 100

Prenatal Advanced Care Vitamins & Minerals with 5-MTHF provides folate, iron and other nutrients that can help fill dietary gaps and support normal blood formation and energy use.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality47

Iodine, zinc and several trace minerals have clearly identified forms, while copper oxide is a weaker choice for copper availability. Many other nutrient forms are named, but their quality cannot be compared confidently.

Ingredient Transparency79

Amounts and nearly all nutrient forms are disclosed, making most of the formula easy to identify. The proportions within mixed forms and the biotin preparation remain unclear.

Value For Money37

Iron and zinc are costly at the serving price, while selenium and chromium compare especially poorly for the amounts supplied. Other trace minerals offer middling value, with much of the broader formula still uncertain.

Customer Satisfaction73

Customer feedback is favorable, but it comes from a small number of ratings. That makes the satisfaction pattern less settled and does not establish effectiveness or safety.

Product Focus41

The broad nutrient mix mainly helps fill dietary gaps relevant to normal blood formation and energy use. Its many possible nutrient roles do not establish extra benefits when intake is already adequate.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.69
Customer rating
4.8 · 62 ratings
Report analysis

Goals

Impact
Highest effect
B+ Ingredient FitA+ PathwaysA- EvidenceA+ Formulation Logic
Folate · 1530 mcg DFEVitamin B12 · 200 mcgVitamin D · 50 mcgMagnesium · 100 mgVitamin K · 40 mcgSelenium · 70 mcgZinc · 20 mgVitamin C · 250 mg
Study evidence
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Zinc Supportive 60 studies
Immunity
Impact
Highest effect
C Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 100 mgVitamin C · 250 mgZinc · 20 mgVitamin A · 1500 mcg RAEVitamin D · 50 mcgSelenium · 70 mcg
Study evidence
Iron Supportive 23 studies
Magnesium Supportive 8 studies
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
Impact
Moderate effect
C+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Iodine · 150 mcgVitamin D · 50 mcgVitamin B5 · 10 mgMagnesium · 100 mgRiboflavin · 5 mgThiamin · 5 mgVitamin B12 · 200 mcgIron · 27 mg
Study evidence
Iodine Adverse 3 studies
Iron Supportive 74 studies
Magnesium Supportive 4 studies
Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies
Impact
High effect
B- Ingredient FitD+ PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 30 mcgVitamin D · 50 mcgZinc · 20 mgIron · 27 mgVitamin C · 250 mg
Study evidence
Biotin Supportive 4 studies
Copper Adverse 4 studies
Folate Mixed 15 studies
Iodine No effect 1 study
Iron Disputed 25 studies
Niacin Disputed 2 studies
Selenium Disputed 7 studies
Vitamin A Disputed 13 studies
Vitamin D Disputed 34 studies
Vitamin E No effect 3 studies
Zinc Supportive 22 studies
Bone Health
Impact
High effect
C Ingredient FitB+ PathwaysA+ EvidenceA+ Formulation Logic
Vitamin K · 40 mcgMagnesium · 100 mgCalcium · 200 mgVitamin D · 50 mcgCopper · 2 mgManganese · 2 mgZinc · 20 mgVitamin C · 250 mg
Study evidence
Calcium Supportive 144 studies
Copper Disputed 20 studies
Folate Supportive 50 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Vitamin A Adverse 56 studies
Vitamin C Supportive 46 studies
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Zinc Supportive 33 studies
Impact
High effect
D+ Ingredient FitC+ PathwaysA+ EvidenceA+ Formulation Logic
Folate · 1530 mcg DFEVitamin B12 · 200 mcgVitamin B6 · 4 mgMolybdenum · 75 mcgSelenium · 70 mcgMagnesium · 100 mgVitamin E · 40 mgZinc · 20 mgVitamin C · 250 mgRiboflavin · 5 mg
Study evidence
Folate Supportive 16 studies
Magnesium Supportive 19 studies
Selenium Supportive 10 studies
Vitamin C Supportive 9 studies
Vitamin E Supportive 23 studies
Zinc Supportive 30 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Beta-Carotene, Retinol)
1500 mcg RAE
Vitamin C (Ascorbic Acid)
250 mg
Vitamin D3 (Cholecalciferol)
50 mcg
Vitamin E (Alpha-Tocopherol)
40 mg
Vitamin K1 (Phylloquinone)
40 mcg
Vitamin B1 (Thiamine Mononitrate)
5 mg
Vitamin B2 (Riboflavin, Riboflavin 5-Phosphate)
5 mg
Vitamin B3 (Niacinamide)
20 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
4 mg
Folate (Calcium L-5-Methyltetrahydrofolate)
1530 mcg DFE
Vitamin B12 (Cyanocobalamin)
200 mcg 21
Biotin
30 mcg
Vitamin B5 (Calcium Pantothenate)
10 mg
Calcium (Calcium Carbonate)
200 mg
Iron (Ferrous Bisglycinate Chelate)
27 mg 69
Iodine (Potassium Iodide)
150 mcg 90
Magnesium (Magnesium Oxide)
100 mg
Zinc (Zinc Citrate)
20 mg 74
Selenium (Selenium Glycinate Complex)
70 mcg 51
Copper (Cupric Oxide)
2 mg 62
Manganese (Manganese Citrate)
2 mg
Chromium (Chromium Nicotinate Glycinate Chelate)
100 mcg 47
Molybdenum (Molybdenum Glycinate)
75 mcg 79
Gluten Free Dairy Free Pregnant Women 18–50 No Allergies Children 4+
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
A serving provides 150 mcg of iodine at a relatively high cost per serving. The iodine comes from potassium iodide. The amount is clearly listed.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The iodine comes from potassium iodide. A marine source is not indicated, so seaweed contamination concerns do not apply to the stated source.
Iodine Form & Bioavailability
The iodine comes from potassium iodide.
Marine Source Purity & Sourcing
A marine source is not indicated, so seaweed contamination concerns do not apply to the stated source.

Dose, Safety & Label Transparency100

A serving lists 150 mcg of iodine. The amount is below the stated adult upper intake level.
Dosage Efficacy for Daily Support
A serving lists 150 mcg of iodine.
Dosage Safety & Upper Limits
The listed 150 mcg is below the stated adult upper intake level.
Elemental Iodine Transparency
The iodine amount per serving is listed.

Value50

The cost per serving is relatively high.
Price Per Effective Serving
The cost per serving is relatively high.
A- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
It provides 75 mcg of molybdenum per serving at a high cost per serving. It uses molybdenum glycinate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability85

It uses molybdenum glycinate. No TRAACS branded source is indicated.
Molybdenum Chemical Form
It uses molybdenum glycinate.
Branded or Patented Source
No TRAACS branded source is indicated.

Dose, Safety & Label Transparency88

It supplies 75 mcg of molybdenum per serving. The 75 mcg per serving is below the adult upper intake level.
Elemental Dose Optimization
It supplies 75 mcg of molybdenum per serving.
Upper Limit (UL) Safety Compliance
The 75 mcg per serving is below the adult upper intake level.

Value50

The cost per serving is relatively high.
Price per Effective Serving
The cost per serving is relatively high.
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyF Value
+1
It provides 20 mg zinc per serving at a high cost per serving. It uses zinc citrate. It also provides 2 mg copper.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

It uses zinc citrate.
Zinc Form Bioavailability
It uses zinc citrate.

Dose, Safety & Label Transparency91

20 mg of zinc per serving can support nutritional maintenance. The serving also contains 2 mg copper, giving a zinc-to-copper ratio of 10:1.
Elemental Dose Transparency
The label states the zinc amount and its source.
Zinc Dosage Safety & Effectiveness
20 mg of zinc per serving can support nutritional maintenance.
Zinc-to-Copper Mineral Balance
The serving also contains 2 mg copper, giving a zinc-to-copper ratio of 10:1.

Value30

The cost per serving is high.
Price Per Serving Efficiency
The cost per serving is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  7. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  8. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  9. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  10. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  11. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  12. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsBone Health forFolate
  13. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate Bone Health forVitamin B6
  14. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsBone Health forFolate
  15. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsBone Health forFolate
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  20. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium