Regeneration

Regeneration

NaturesPlus4.8 (299 ratings)
Format:Softgel Quantity: 90 Softgel(s) · 30 servings
Goals

About this product

Broad nutrient support is the clearest use, especially when the diet falls short in B vitamins or zinc. B vitamins contribute to normal energy use, while folate and B12 support blood formation. These roles do not establish an immediate lift in concentration, productivity or metabolism when intake is already adequate.

The 15 mg zinc serving is accompanied by 1 mg copper, and copper's glycinate form is a useful detail. Calcium at 100 mg and magnesium at 50 mg provide limited mineral coverage for bone support. Meanwhile, 50 mg of vitamin B6 is well above a routine nutritional amount and deserves more attention than the long list of added herbs.

The botanical additions leave substantial uncertainty about practical benefits. Green tea lacks an EGCG amount and caffeine information, while the milk thistle declaration does not clearly identify an extract preparation. Several ingredient forms and mixture details are also unclear, and the relatively high serving cost is difficult to justify for someone seeking only basic nutrient coverage.

Who is it for
  • Adults with dietary gaps who want broad vitamin and mineral coverage and have reviewed the high B6 amount
Best for
  • Supporting normal energy use when nutrient intake is low
  • Adding maintenance-level zinc with a stated copper contribution

Pros

  • Zinc and copper amounts are both stated
  • Copper uses the glycinate form
  • Folate and B12 add nutritional support for blood formation

Cons

  • Calcium and magnesium amounts offer limited bone-mineral coverage
  • Unclear botanical preparations weaken the case for the wider claimed uses
  • Several generic mineral-chelate names leave the precise forms uncertain
  • Relatively high cost for basic nutritional support

Warnings

  • The 50 mg B6 serving is well above routine nutritional needs; review total B6 intake before combining it with other supplements.
  • Glucosamine includes a crustacean-shell source, which matters for people avoiding shellfish because of allergy.
  • Green tea caffeine content is not stated, leaving its suitability uncertain for people who need to avoid caffeine.

Product analysis

52 out of 100

Regeneration combines vitamins, minerals and herbs, with its clearest benefits coming from filling nutrient gaps affecting normal immune, blood and energy functions. Several ingredients are costly for their contributions, weakening its value.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality44

Some ingredients have clearly identified, favorable forms, including copper and vitamin B6. Many other forms remain uncertain or unspecified, and two mixtures lack component proportions.

Ingredient Transparency74

All listed amounts and most forms are disclosed. Some form descriptions and the proportions within glucosamine and ginkgo mixtures are missing, limiting precise comparisons.

Value For Money36

Several nutrients and milk thistle are costly at the full serving price, while B6 and biotin offer more reasonable value. Many other ingredients have uncertain value, leaving a weak price case for the large combination.

Customer Satisfaction76

Customer feedback is very positive. A few hundred ratings give a broader view of satisfaction, without establishing health benefits.

Product Focus35

Filling dietary gaps is clearer than the many proposed liver, hormone or cosmetic benefits. The large ingredient list makes the formula complex without establishing equally broad outcomes.

Format
Softgel
Container
90 Softgel(s)
Per serving
$1.41
Customer rating
4.8 · 299 ratings
Report analysis

Goals

Impact
High effect
C Ingredient FitB+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 667 mcg DFEVitamin B12 · 100 mcgVitamin D · 10 mcgMagnesium · 50 mgSelenium · 20 mcgZinc · 15 mgVitamin C · 200 mg
Study evidence
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Zinc Supportive 60 studies
Impact
Moderate effect
C- Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Iodine · 150 mcgVitamin D · 10 mcgVitamin B5 · 100 mcgMagnesium · 50 mgRiboflavin · 50 mgThiamin · 50 mgVitamin B12 · 100 mcgIron · 4.5 mgPotassium · 25 mg
Study evidence
Iodine Adverse 3 studies
Iron Supportive 74 studies
Magnesium Supportive 4 studies
Potassium Supportive 2 studies
Thiamin Disputed 12 studies
Vanadium Adverse 2 studies
Vitamin D Supportive 32 studies
Bone Health
Impact
High effect
D+ Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 50 mgCalcium · 100 mgVitamin D · 10 mcgCopper · 1 mgManganese · 5 mgZinc · 15 mgVitamin C · 200 mg
Study evidence
Calcium Supportive 144 studies
Copper Disputed 20 studies
Folate Supportive 50 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Potassium Supportive 39 studies
Vitamin A Adverse 56 studies
Vitamin C Supportive 46 studies
Vitamin D Supportive 202 studies
Zinc Supportive 33 studies
Immunity
Impact
High effect
D+ Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 50 mgVitamin C · 200 mgZinc · 15 mgVitamin A · 7508 mcgVitamin D · 10 mcgSelenium · 20 mcg
Study evidence
Green Tea Not classified 2 studies
Iron Supportive 23 studies
Magnesium Supportive 8 studies
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
Impact
High effect
D Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Folate · 667 mcg DFEVitamin B12 · 100 mcgVitamin B6 · 50 mgMolybdenum · 20 mcgSelenium · 20 mcgMagnesium · 50 mgMilk Thistle · 75 mgVitamin E · 134 mgZinc · 15 mgVitamin C · 200 mgCholine · 50 mgRiboflavin · 50 mg
Study evidence
Choline Supportive 6 studies
Folate Supportive 16 studies
Green Tea Disputed 16 studies
Magnesium Supportive 19 studies
Selenium Supportive 10 studies
Vitamin C Supportive 9 studies
Vitamin E Supportive 23 studies
Zinc Supportive 30 studies
Impact
Moderate effect
C Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 300 mcgNiacin · 50 mg NEVitamin B12 · 100 mcgRiboflavin · 50 mgThiamin · 50 mgVitamin B5 · 100 mcgVitamin B6 · 50 mgVitamin D · 10 mcgZinc · 15 mgMagnesium · 50 mgGreen Tea · 25 mg
Study evidence
Biotin Supportive 5 studies
Chromium Supportive 47 studies
Green Tea Supportive 31 studies
Iodine Mixed 17 studies
Magnesium Supportive 61 studies
Niacin Supportive 17 studies
Selenium Mixed 28 studies
Thiamin Supportive 11 studies
Vanadium Supportive 7 studies
Vitamin B6 Supportive 16 studies
Vitamin D Supportive 65 studies
Zinc Supportive 12 studies

Ingredients

IngredientAmount per servingScore
Calories
20 Calorie(s)
Total Fat
1.5 Gram(s)
Vitamin A (Beta-Carotene)
7508 mcg
Vitamin C (Ascorbic Acid)
200 mg
Vitamin D (Ergocalciferol)
10 mcg
Vitamin E (D-Alpha-Tocopheryl Acetate)
134 mg
Thiamine (Thiamine Hydrochloride)
50 mg 76
Riboflavin
50 mg 54
Niacin (Niacinamide)
50 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
50 mg 67
Folate (Folic Acid)
667 mcg DFE
Vitamin B12 (Cyanocobalamin)
100 mcg 21
Biotin
300 mcg 59
Pantothenic Acid (Calcium Pantothenate)
100 mcg
Choline (Choline Bitartrate)
50 mg 58
Calcium (Calcium Amino Acid Chelate/Complex)
100 mg
Iron (Iron Amino Acid Chelate/Complex)
4.5 mg 45
Iodine (Kelp)
150 mcg 58
Magnesium (Magnesium Amino Acid Chelate/Complex)
50 mg
Zinc (Zinc Amino Acid Chelate)
15 mg 58
Selenium (Selenium Amino Acid Chelate)
20 mcg
Copper (Copper Glycinate)
1 mg 78
Manganese (Manganese Amino Acid Chelate/Complex)
5 mg 72
Chromium (Chromium Polynicotinate)
50 mcg
Molybdenum (Molybdenum Amino Acid Complex)
20 mcg
Potassium (Potassium Glycero-Phosphate)
25 mg
Milk Thistle (Silymarin)
75 mg 40
Juniper
50 mg
Celery
50 mg
Cayenne
50 mg
Echinacea
50 mg
Bioflavonoids (Citrus limon)
50 mg
Inositol
50 mg
Korean Ginseng root complex (Ginsenosides)
50 mg
Borage seed Oil (Gamma-Linolenic Acid)
31.5 mg
Glucosamine Sulfate (Aminomonosaccharide, Bovine Cartilage, Crustacean shell)
30 mg
Parsley
27 mg
Green Tea leaf extract (Polyphenols)
25 mg 8
Ginkgo biloba (Ginkgo Flavone-Glycosides, Terpene Lactones)
10 mg
Bilberry (Anthocyanosides)
5 mg
Grape seed extract (Polyphenols)
5 mg
Oleoresin Turmeric (Curcumin)
5 mg
Vanadium (Vanadyl Sulfate)
1 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
A serving provides 5 mg of manganese. The cost per serving is high. It uses Manganese Amino Acid Chelate, but the specific amino acid is not named.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

It uses Manganese Amino Acid Chelate, but the specific amino acid is not named.
Manganese Chemical Form
It uses Manganese Amino Acid Chelate, but the specific amino acid is not named.

Dose, Safety & Label Transparency100

A serving provides 5 mg of manganese. The amount is stated separately.
Manganese Dosage Efficacy & Safety
A serving provides 5 mg of manganese.
Elemental Weight Disclosure
The manganese amount is stated separately.

Value20

The cost per serving is high.
Price per Serving vs. Median
The cost per serving is high.
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
Each serving provides 1 mg of copper at a high cost. It uses Copper Glycinate. It also contains 15 mg of zinc.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The label names Copper Glycinate and states the copper amount.
Copper Form Bioavailability
It uses Copper Glycinate.
Elemental Copper Labeling Clarity
The label states 1 mg of copper and names Copper Glycinate as its source.

Dose, Safety & Label Transparency86

The serving has 1 mg of copper and 15 mg of zinc.
Copper Dosage Safety & Efficacy
The serving provides 1 mg of copper.
Zinc-to-Copper Balance
The serving also provides 15 mg of zinc alongside 1 mg of copper.

Value20

The cost per serving is high.
Price Per Serving Efficiency
The cost per serving is high.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
The 50 mg of thiamin per serving is a high amount, but its cost per amount of thiamin is high. It uses thiamine hydrochloride.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

It uses thiamine hydrochloride, a standard water-soluble form. The listed ingredients show no configured artificial colors or sweeteners.
Thiamin Chemical Form
It uses thiamine hydrochloride, a standard water-soluble form.
Excipient Purity
The listed ingredients show no configured artificial colors or sweeteners.

Dose, Safety & Label Transparency100

The label states 50 mg of thiamin per serving, a high amount.
Thiamin Dosage Potency
The serving provides 50 mg of thiamin, a high amount.
Label Transparency & Proprietary Blends
The thiamin amount per serving is stated.

Value40

The cost is high for the amount of thiamin provided.
Price per Declared Dose
The cost is high for the amount of thiamin provided.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  7. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  8. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  9. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  10. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  11. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  12. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsBone Health forFolate
  13. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate Bone Health forVitamin B6
  14. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsBone Health forFolate
  15. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsBone Health forFolate
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  20. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium