Special Two

Special Two

NOW4.7 (2,080 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 30 servings
Goals
$16.69 $0.55 per serving

Product analysis

53 out of 100

Special Two provides broad vitamin and mineral support for filling dietary gaps. Its many plant and enzyme additions make it less focused, while small calcium and magnesium amounts limit its usefulness as a dedicated bone supplement.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality52

Ingredient quality varies, with favorable forms for several minerals alongside less favorable vitamin D and folate forms. Many other ingredients cannot be judged confidently, so the broad mix does not establish uniformly high quality.

Ingredient Transparency71

All ingredient amounts are stated, but several forms are missing. The proportions of the combined vitamin C and calcium forms are also undisclosed, limiting a full understanding of the mixture.

Value For Money40

Value is uneven, with favorable comparisons for some nutrients but high costs for several others. The broad ingredient list therefore does not establish economical delivery of each nutrient.

Customer Satisfaction85

Customer feedback is favorable across a substantial review pool. Those opinions describe satisfaction rather than establishing the benefits of every ingredient.

Product Focus13

The formula covers many nutritional needs and health goals, which makes it less tailored to one purpose. Its clearest role is helping fill dietary gaps rather than providing stronger effects simply through a longer ingredient list.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.55
Customer rating
4.7 · 2,080 ratings
Report analysis

Goals

Impact
Moderate effect
D Ingredient FitF PathwaysA+ EvidenceA Formulation Logic
Zinc · 15 mgVitamin C · 500 mgCopper · 1 mgSelenium · 50 mcgLycopene · 250 mcgGreen Tea · 50 mgVitamin E · 200 IU

Vitamin C and copper support connective-tissue processes, zinc contributes to normal skin repair, and B vitamins support skin nutrition. Green tea and small carotenoid amounts offer less certain cosmetic support because skin findings are mixed and preparation-specific.

How this product is rated for Skin Health

Ingredient fit45

Skin-related ingredients are part of a broader formula with other purposes. Smaller or unresolved amounts limit the contribution in the saved dose assessment.
Goal fit
Skin-related ingredients are part of a broader formula with other purposes.
Dose adequacy
Smaller or unresolved amounts limit the contribution in the saved dose assessment.

Pathways18

The strongest saved contribution relates to dermal collagen matrix.
Depth
The strongest saved contribution relates to dermal collagen matrix.
Breadth
The saved findings show limited coverage across the different skin-related mechanisms.

Evidence100

Vitamin C provides the strongest evidence contribution among the assessed ingredients; this does not guarantee a visible skin benefit.
Evidence strength
Vitamin C provides the strongest evidence contribution among the assessed ingredients; this does not guarantee a visible skin benefit.
Studied preparation
The ingredients assessed at relevant amounts match preparations recognized in the saved findings.

Formulation logic94

The assessed ingredients can contribute independently or have their required partner.
Partner coverage
The assessed ingredients can contribute independently or have their required partner.
Conflicts
No configured ingredient conflicts were identified in the saved findings.
Effective doses
Some assessed ingredients fall below the saved minimum amount threshold: Vitamin A, Vitamin E.
Study evidence
Biotin Supportive 10 studies
Copper Supportive 16 studies
Green Tea Supportive 37 studies
Lycopene Supportive 20 studies
Niacin Supportive 61 studies
Selenium Supportive 22 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies
Impact
Moderate effect
F Ingredient FitC PathwaysA- EvidenceA Formulation Logic
Zinc · 15 mgVitamin E · 200 IUVitamin C · 500 mgCopper · 1 mgVitamin A · 10000 IU

Riboflavin may help when a deficiency is causing eye problems. Prolonged severe deficiency can contribute to cataracts, so correcting it matters, but extra riboflavin is not known to improve vision when you already get enough.

How this product is rated for Eye Health

Ingredient fit39

Riboflavin is relevant to eye problems caused by deficiency.
Goal fit
Riboflavin is relevant to eye problems caused by deficiency.
Dose adequacy
Zinc: 15 mg; Lycopene: 0.25 mg. These serving amounts do not guarantee better vision.

Pathways60

Riboflavin is relevant to eye problems caused by deficiency.
Depth
Riboflavin is relevant to eye problems caused by deficiency.
Breadth
Vitamin A relates to the visual cycle, while other nutrients relate to antioxidant functions; these roles do not show broad improvement in sight.

Evidence88

Riboflavin is relevant to eye problems caused by deficiency.
Evidence strength
Riboflavin is relevant to eye problems caused by deficiency.
Studied preparation
The declared nutrient forms do not by themselves show that the complete eye-health combination is reproduced.

Formulation logic93

No particular ingredient conflict is identified.
Partner coverage
Copper is present alongside zinc; this does not by itself confirm adequate copper balance.
Conflicts
No particular ingredient conflict is identified.
Effective doses
Zinc: 15 mg; Lycopene: 0.25 mg. These serving amounts do not guarantee better vision.
Study evidence
Copper Supportive 7 studies
Lycopene Supportive 5 studies
Riboflavin Supportive 69 studies
Rutin Not classified 1 study
Selenium Supportive 15 studies
Vitamin A Supportive 65 studies
Vitamin C Disputed 24 studies
Vitamin D Disputed 35 studies
Vitamin E Disputed 35 studies
Zinc Supportive 39 studies
Impact
High effect
C Ingredient FitA+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 400 mcgVitamin B12 · 100 mcgVitamin D · 400 IUMagnesium · 50 mgSelenium · 50 mcgZinc · 15 mgVitamin C · 500 mg

B vitamins contribute nutrients involved in energy metabolism, while folate and vitamin B12 contribute to normal blood formation. Iodine and iron can help fill low intakes that affect thyroid function and blood health, respectively. Zinc, selenium and vitamin C contribute to normal antioxidant and immune functions. These nutritional roles do not establish additional health benefits when intake is adequate, and the higher B-vitamin amounts do not establish stronger effects.

How this product is rated for Everyday Health

Ingredient fit63

Nutrients provide the relevant general-health contribution, while other actives make the formula less focused on these nutritional roles. The relevant nutrient amounts provide substantial, though uneven, contributions compared with the saved reference amounts.
Goal fit
Nutrients provide the relevant general-health contribution, while other actives make the formula less focused on these nutritional roles.
Dose adequacy
The relevant nutrient amounts provide substantial, though uneven, contributions compared with the saved reference amounts.

Pathways100

Normal energy metabolism is the strongest connection. Contributions span energy metabolism, blood formation, and antioxidant and immune functions.
Depth
Normal energy metabolism is the strongest connection.
Breadth
Contributions span energy metabolism, blood formation, and antioxidant and immune functions.

Evidence82

Vitamin B9 (Folate) provides the strongest supported nutritional contribution; this does not establish extra benefit when intake is adequate.
Evidence strength
Vitamin B9 (Folate) provides the strongest supported nutritional contribution; this does not establish extra benefit when intake is adequate.
Studied preparation
The relevant nutrient declarations are accepted in the supplied preparation findings; no superiority of form or delivery is established.

Formulation logic100

The counted nutrient amounts meet the saved comparison threshold, and no configured conflict or missing required partner was identified.
Partner coverage
The relevant ingredients can contribute without a required missing partner; this does not establish added benefit from combining them.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
The counted ingredients reach the saved amount threshold, which is a comparison marker rather than a proven clinical effect.
Study evidence
Bromelain Supportive 11 studies
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Zinc Supportive 60 studies
Impact
Moderate effect
C- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Iodine · 150 mcgVitamin D · 400 IUVitamin B5 · 50 mgMagnesium · 50 mgRiboflavin · 50 mgThiamin · 50 mgVitamin B12 · 100 mcgIron · 10 mgPotassium · 50 mg

B vitamins support normal energy metabolism, while iron contributes to oxygen transport and magnesium supports energy-related processes. Vitamin C and iodine add nutritional support. B12, vitamin D, magnesium and potassium provide smaller contributions at these serving amounts, and the botanical declaration gives no quantified caffeine contribution.

How this product is rated for Energy

Ingredient fit55

The formula mainly addresses broader nutritional needs, with a limited focus on energy. The counted amounts provide substantial support, with some smaller contributions.
Goal fit
The formula mainly addresses broader nutritional needs, with a limited focus on energy.
Dose adequacy
The counted amounts provide substantial support, with some smaller contributions.

Pathways0

The saved contribution is nutritional, without meaningful coverage of the specific alertness or performance mechanisms assessed. No specific energy mechanism reaches the saved coverage threshold.
Depth
The saved contribution is nutritional, without meaningful coverage of the specific alertness or performance mechanisms assessed.
Breadth
No specific energy mechanism reaches the saved coverage threshold.

Evidence97

Iron supplies the strongest relevant evidence at a counted amount, with benefits limited to the particular contexts and outcomes assessed. Most counted preparations match trial materials, while some retain preparation uncertainty.
Evidence strength
Iron supplies the strongest relevant evidence at a counted amount, with benefits limited to the particular contexts and outcomes assessed.
Studied preparation
Most counted preparations match trial materials, while some retain preparation uncertainty.

Formulation logic100

The counted ingredients can contribute independently or have their needed partner. No configured ingredient conflict was identified. All ingredients counted here reach a meaningful amount in the saved comparison.
Partner coverage
The counted ingredients can contribute independently or have their needed partner.
Conflicts
No configured ingredient conflict was identified.
Effective doses
All ingredients counted here reach a meaningful amount in the saved comparison.
Study evidence
Iodine Adverse 3 studies
Iron Supportive 74 studies
Magnesium Supportive 4 studies
Potassium Supportive 2 studies
Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies
Immunity
Impact
High effect
D- Ingredient FitC+ PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 50 mgVitamin C · 500 mgZinc · 15 mgVitamin A · 10000 IUVitamin D · 400 IUSelenium · 50 mcg

Vitamin C supports normal immune nutrition and may modestly shorten colds with regular use, without establishing infection prevention or treatment of an established cold. Zinc provides a separate nutritional contribution to normal immune function, especially when intake is low. The B vitamins add support when low intake would otherwise impair immune-cell function. The declared serving does not establish the regular regimen used in the cold-duration evidence.

How this product is rated for Immunity

Ingredient fit43

Relevant nutrient declarations provide the immune connection. Small or unresolved amounts limit some contributions without establishing ingredient absence.
Goal fit
The relevant declared ingredients connect with immune support; additional ingredients and other product purposes make the focus less exclusive.
Dose adequacy
Declared amounts contribute to varying degrees; the comparison does not make higher quantities a proven prevention or treatment dose.

Pathways65

The saved findings concentrate on innate immune cell activity. These associations do not establish clinical immune protection.
Depth
The strongest saved association is innate immune cell activity, which does not establish a measured immune or infection outcome.
Breadth
Two immune-related areas meet the saved coverage threshold; the remaining areas contribute less or nothing.

Evidence100

Vitamin C leads the counted contribution. Normal nutrient functions and any regular-use cold findings retain their distinct limitations.
Evidence strength
Vitamin C provides the strongest counted contribution, with the specific nutritional or regular-use limitations retained.
Studied preparation
The counted preparations are accepted in the saved comparison; this does not independently establish clinical equivalence or an advantage for this product.

Formulation logic95

No required partner or configured conflict was found. Vitamin A, Vitamin E do not meet the saved amount inclusion threshold.
Partner coverage
No required partner is missing for the counted ingredients, without establishing an added immune benefit from combining them.
Conflicts
No configured formulation conflict was found at the supplied ingredient amounts and partner declarations.
Effective doses
Vitamin A, Vitamin E do not meet the saved amount threshold; the other counted ingredients do. This does not establish a proven immune-response dose.
Study evidence
Bromelain Not classified 1 study
Green Tea Not classified 2 studies
Iron Supportive 23 studies
Magnesium Supportive 8 studies
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
Impact
Moderate effect
F Ingredient FitD- PathwaysA- EvidenceA Formulation Logic
Vitamin D · 400 IUVitamin E · 200 IUVitamin C · 500 mgBlue-Green Algae · 400 mgGreen Tea · 50 mg

Zinc may help when low zinc contributes to ongoing low-level inflammation. Getting enough supports normal immune function, but extra zinc isn't known to provide the same benefit when your intake is already adequate. The other ingredients don't turn this conditional nutrient benefit into a predictable reduction in inflammation or joint symptoms.

How this product is rated for Inflammation

Ingredient fit29

Zinc relates to inflammation mainly when zinc levels are low.
Goal fit
Zinc relates to inflammation mainly when zinc levels are low.
Dose adequacy
The selected serving supplies Zinc 15 mg, Lycopene 0.25 mg, Selenium 50 mcg. These amounts are comparisons, not guarantees of symptom relief.

Pathways42

The connection concerns processes involved in inflammation; it does not predict a noticeable reduction in pain or other symptoms.
Depth
The strongest connection concerns oxidative and mitochondrial stress, a process involved in inflammation rather than a prediction of symptom relief.
Breadth
The connection is concentrated in one inflammation process rather than spread broadly across several.

Evidence87

Zinc may help when low zinc contributes to ongoing low-level inflammation. Getting enough supports normal immune function, but extra zinc isn't known to provide the same benefit when your intake is already adequate.
Evidence strength
Zinc may help with inflammation related to low zinc; benefits when zinc intake is adequate are unclear.
Studied preparation
The named ingredient forms are compatible with the preparation context used here; that does not guarantee the same practical benefit.

Formulation logic94

No particular ingredient conflict is identified. A required extra partner is not identified for the ingredients with a contribution.
Partner coverage
No required additional ingredient partner is identified for the ingredients with a contribution.
Conflicts
No particular conflict between the ingredients is identified.
Effective doses
Some relevant amounts are low or unresolved, so the ingredients do not all have comparable dose information.
Study evidence
Bromelain Supportive 12 studies
Lycopene Supportive 15 studies
Magnesium Supportive 41 studies
Papain Not classified

No linked studies yet.

Rutin Supportive 6 studies
Selenium Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin D Supportive 101 studies
Vitamin E Supportive 20 studies
Zinc Supportive 64 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Beta-Carotene)
10000 IU 69
Vitamin C (Ascorbic Acid, Calcium Ascorbate)
500 mg 73
Vitamin D (Ergocalciferol)
400 IU 35
Vitamin E (D-Alpha-Tocopheryl Succinate)
200 IU 66
Thiamine (Thiamine Hydrochloride)
50 mg 76
Riboflavin
50 mg 62
Niacin (Niacinamide)
50 mg 65
Vitamin B6 (Pyridoxine Hydrochloride)
50 mg 73
Folate (Folic Acid)
400 mcg 12
Vitamin B12 (Cyanocobalamin)
100 mcg 21
Biotin
100 mcg
Pantothenic Acid (Calcium Pantothenate)
50 mg 70
Calcium (Calcium Ascorbate, Calcium Carbonate)
100 mg
Iron (Ferrochel Iron Bisglycinate)
10 mg 57
Iodine (Potassium Iodide)
150 mcg 90
Magnesium (Magnesium Oxide)
50 mg
Zinc (Zinc Picolinate)
15 mg 82
Selenium (L-Selenomethionine)
50 mcg
Copper (Copper Bisglycinate)
1 mg 84
Manganese (Manganese Bisglycinate)
5 mg 90
Chromium (Chromium Picolinate)
100 mcg 47
Molybdenum (Sodium Molybdate)
50 mcg 64
Potassium (Potassium Chloride)
50 mg
Choline (Choline Bitartrate)
50 mg 55
Inositol
50 mg
PABA
30 mg 78
organic Spirulina
400 mg 53
Chlorella
50 mg
Alfalfa juice concentrate
50 mg
Alpha Lipoic Acid
50 mg
Green Tea extract
50 mg 8
Milk Thistle extract (Silymarin)
50 mg 8
Rutin powder (Sophora japonica)
25 mg 75
Alfalfa
4 mg
organic Rose Hip powder
4 mg
Lutein (Marigold flowers extract)
250 mcg
Lycopene (natural Tomato extract)
250 mcg
Amylase
10 mg
Lipase
10 mg
Bromelain (Pineapple)
20 mg 47
Papain
25 mg 90
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
Each serving supplies 150 mcg of iodine as potassium iodide, an amount that fits the evaluation for daily support. A whole-product serving costs about $0.56.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

Iodine is supplied as potassium iodide. No marine source is identified in the saved facts, so the seaweed sourcing criterion does not apply.
Iodine Form & Bioavailability
The iodine is listed as potassium iodide, a form rated favorably in the evaluation.
Marine Source Purity & Sourcing
No marine source is identified in the saved facts, so the seaweed sourcing criterion does not apply.

Dose, Safety & Label Transparency100

The label states 150 mcg of iodine per serving, an amount that fits the evaluation for daily support and does not exceed its upper limit.
Dosage Efficacy for Daily Support
The 150 mcg per serving fits the evaluation for daily support.
Dosage Safety & Upper Limits
The stated 150 mcg per serving does not exceed the evaluated upper limit.
Elemental Iodine Transparency
The label states the iodine amount: 150 mcg per serving.

Value50

A whole-product serving costs about $0.56.
Price Per Effective Serving
A whole-product serving costs about $0.56.
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
A serving provides 5 mg of manganese as manganese bisglycinate. The amount aligns with the evaluation’s bone and joint support target.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

Manganese bisglycinate is an amino acid chelate valued for absorption and stability.
Manganese Chemical Form
Manganese bisglycinate is an amino acid chelate valued for absorption and stability.

Dose, Safety & Label Transparency100

The stated 5 mg per serving aligns with the bone and joint support target.
Manganese Dosage Efficacy & Safety
The 5 mg per serving aligns with the evaluation’s target for bone and joint support.
Elemental Weight Disclosure
The label states both the 5 mg manganese amount and its source.

Value50

At about $0.56 per whole-product serving, the price is in the middle of the collection.
Price per Serving vs. Median
At about $0.56 per whole-product serving, the price is in the middle of the collection.
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
Four capsules provide 1 mg of copper as bisglycinate, a chelated form with favorable absorption potential. The 15:1 zinc-to-copper ratio fits the balance used for this comparison.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The serving provides 1 mg of copper as bisglycinate, a chelated form with favorable absorption potential.
Copper Form Bioavailability
Copper bisglycinate is an amino acid chelate with favorable absorption potential.
Elemental Copper Labeling Clarity
The saved facts identify 1 mg of copper and name copper bisglycinate as its source.

Dose, Safety & Label Transparency86

The serving provides 1 mg of copper. The 15 mg of zinc and 1 mg of copper make a 15:1 ratio, which fits the balance used in this comparison.
Copper Dosage Safety & Efficacy
The serving provides 1 mg of copper.
Zinc-to-Copper Balance
The 15 mg of zinc and 1 mg of copper make a 15:1 ratio, which fits the balance used in this comparison.

Value50

At about $0.56 per whole-product serving, the price is mid-range in this comparison. The serving includes 1 mg of copper.
Price Per Serving Efficiency
At about $0.56 per whole-product serving, the price is mid-range in this comparison. The serving includes 1 mg of copper.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  7. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  8. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  9. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  10. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  11. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  12. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsBone Health forFolate
  13. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate Bone Health forVitamin B6
  14. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsBone Health forFolate
  15. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsBone Health forFolate
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  20. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium