The Big One Plus without Iron
Goals
$57.00 $0.63 per serving
Product analysis
The Big One Plus without Iron supplies a broad range of vitamins and minerals to support normal immune function, energy use and blood formation when intake is low. Missing proportions in several blends make it harder to compare the amounts of each nutrient form.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality57
Several B vitamins and trace minerals use favorable forms. Other ingredients lack enough detail for a close comparison, and the vitamin K blend does not identify a specific MK-7 preparation.
Ingredient Transparency76
All nutrient amounts and most forms are stated. The proportions of several blended forms are missing, so their individual contributions remain unclear.
Value For Money42
Vitamin K and molybdenum offer some of the clearer value advantages. Several other nutrients are costly at the full serving price, while incomplete comparisons leave part of the value uncertain.
Customer Satisfaction72
Customer ratings indicate very high satisfaction. The smaller pool of customer ratings leaves more uncertainty about wider satisfaction.
Product Focus38
The blend covers many nutritional needs with a large set of active ingredients. Its main benefit is helping fill dietary gaps rather than providing a precise solution for each suggested use.
- Format
Capsule - Container
- 90 Capsule(s)
- Per serving
- $0.63
- Customer rating
- 4.8 · 77 ratings
Goals
Impact
Highest effect
Vitamin C · 125 mgZinc · 15 mgVitamin A · 2400 mcg RAEVitamin D · 50 mcgSelenium · 100 mcg
Vitamin A supports barrier nutrition, while zinc, vitamin D and selenium contribute to normal immune function. Copper, B6, B12 and folate can help when low intake impairs immune cells. These nutritional roles do not establish additional infection protection when intake is adequate. Vitamin E receives saved credit despite mixed outcome findings in specific older populations, and the vitamin C amount did not qualify in the saved findings.
How this product is rated for Immunity
Ingredient fit67
Relevant nutrients make substantial contributions within a broadly targeted formula.
Goal fit
The immune nutrients share the formula with many actives outside the assessed goal.
Dose adequacy
Most credited amounts contribute strongly; vitamin C falls below the saved contribution threshold.
Pathways100
Barrier and antimicrobial defense is the strongest covered area. Barrier defense, immune regulation and oxidative balance reach substantial coverage.
Depth
Barrier and antimicrobial defense has the strongest combined coverage.
Breadth
Barrier defense, immune regulation and oxidative balance reach substantial coverage.
Evidence100
Zinc leads the saved support finding. Credited preparations meet the saved criteria, within the specific evidence limits described for their roles.
Evidence strength
Zinc provides the strongest saved support; that position does not establish a probability of protection.
Studied preparation
Credited preparations meet the saved criteria, without establishing superiority of individual nutrient forms.
Formulation logic100
Credited ingredients clear the saved amount threshold and have no assessed missing partner or conflict.
Partner coverage
Credited ingredients work alone or have their relevant partners.
Conflicts
No assessed ingredient conflict was triggered.
Effective doses
All credited ingredients clear the saved minimum amount threshold, which is not proof of clinical effectiveness.
Impact
Highest effect
Folate · 667 mcg DFEVitamin B12 · 100 mcgVitamin D · 50 mcgVitamin K · 100 mcgBoron · 1 mgSelenium · 100 mcgZinc · 15 mgVitamin C · 125 mg
Folate and the B vitamins provide nutrients relevant to normal metabolism and blood formation. Vitamin D adds a nutritional contribution relevant to bone and mineral health. Zinc and Selenium add further nutritional contributions. These contributions matter when dietary intake is inadequate; additional benefits above adequate intake are not established.
How this product is rated for Everyday Health
Ingredient fit81
The included nutritional ingredients share the formula with ingredients serving other purposes, reducing its general-health focus. Declared amounts provide partial coverage of the saved comparisons; this concerns nutrient availability rather than a proven clinical response.
Goal fit
The included nutritional ingredients share the formula with ingredients serving other purposes, reducing its general-health focus.
Dose adequacy
Declared amounts provide partial coverage of the saved comparisons; this concerns nutrient availability rather than a proven clinical response.
Pathways100
The strongest connection is energy metabolism cofactors. This describes the main supplied functional connection. The findings span several functional areas, indicating broader coverage without establishing added benefit from combining ingredients.
Depth
The strongest connection is energy metabolism cofactors. This describes the main supplied functional connection.
Breadth
The findings span several functional areas, indicating broader coverage without establishing added benefit from combining ingredients.
Evidence82
The saved findings recognize evidence and preparation matches for the included ingredients. Nutritional availability and narrower outcomes do not establish routine broad health improvement.
Evidence strength
Vitamin B9 (Folate) leads the saved evidence comparison; its nutritional or indication-specific evidence does not establish broad benefits above adequate status.
Studied preparation
Included preparations matched the saved comparison, without establishing superiority of delivery or chemical form.
Formulation logic100
Included ingredients had no missing required partners or configured conflicts and reached the saved minimum amount threshold.
Partner coverage
No required partner was missing among the included ingredients; this does not establish synergy.
Conflicts
No configured ingredient conflict was identified in the supplied facts.
Effective doses
All included ingredients reached the saved minimum amount threshold; excluded low amounts are not necessarily nutritionally worthless.
Impact
High effect
Biotin · 200 mcgNiacin · 100 mg NEVitamin B12 · 100 mcgRiboflavin · 25 mgThiamin · 25 mgVitamin B5 · 100 mgVitamin B6 · 25 mgVitamin D · 50 mcgZinc · 15 mg
B vitamins help the body carry out normal energy metabolism. Taking extra amounts does not establish increased energy expenditure when nutrient intake is adequate. Iodine supports thyroid hormone production, so correcting low iodine intake can address a cause of reduced metabolic rate.
How this product is rated for Metabolism Support
Ingredient fit71
The formula contributes nutrients involved in normal metabolism. Its mix and disclosed amounts determine the saved ingredient findings.
Goal fit
The formula has counted nutritional contributions alongside ingredients serving broader purposes.
Dose adequacy
The counted amounts partly meet the saved references; unknown amounts cannot establish a contribution comparable with studied exposures.
Pathways4
The main recorded contribution concerns insulin sensitivity and metabolic hormones; this does not by itself demonstrate increased whole-body energy use.
Depth
The main recorded contribution concerns insulin sensitivity and metabolic hormones; this does not by itself demonstrate increased whole-body energy use.
Breadth
No evaluated pathway reached the coverage criterion.
Evidence100
The saved evidence comparison accepts nutrient or cellular roles, while the supplied scientific context limits claims of increased energy expenditure.
Evidence strength
Vitamin B1 (Thiamin) leads the saved evidence comparison, but its physiological role or metabolic-marker findings do not establish a routine increase in energy expenditure.
Studied preparation
The counted preparations meet the saved preparation comparison; this does not prove a particular form raises metabolic rate more effectively.
Formulation logic100
There are no unmet partner requirements or configured conflicts. The amount findings describe the counted ingredients, without establishing combined metabolic benefits.
Partner coverage
No counted ingredient has an unmet partner requirement in the supplied findings.
Conflicts
No configured ingredient conflict was triggered.
Effective doses
All counted ingredients meet the saved minimum amount criterion, which is not proof of increased metabolic rate.
Impact
High effect
Iodine · 100 mcgVitamin D · 50 mcgVitamin B5 · 100 mgRiboflavin · 25 mgThiamin · 25 mgVitamin B12 · 100 mcg
B vitamins, vitamin C support normal metabolism and can help with tiredness linked to inadequate intake. Folate and B12 also matter for healthy red blood cell formation. Vitamin D fatigue findings concern deficient adults. Higher nutrient amounts do not establish extra energy once needs are met.
How this product is rated for Energy
Ingredient fit72
The formula includes ingredients connected with energy alongside ingredients used for other purposes. The assessed amounts provide partial coverage of the saved references, with some ingredients contributing less than others.
Goal fit
The formula includes ingredients connected with energy alongside ingredients used for other purposes.
Dose adequacy
The assessed amounts provide partial coverage of the saved references, with some ingredients contributing less than others.
Pathways0
No direct alertness or exercise mechanism reaches meaningful coverage; nutritional support is considered separately.
Depth
No direct alertness or exercise mechanism reaches meaningful coverage; nutritional support is considered separately.
Breadth
No direct mechanism reaches the coverage threshold.
Evidence94
The evidence supports specific ingredient roles and nutritional correction, without proving extra everyday energy in adequately nourished adults.
Evidence strength
Vitamin D provides the strongest assessed evidence connection; the population and intended use still limit what benefits can be expected.
Studied preparation
Most assessed preparations match the saved study criteria; iodine does not. This does not establish an unconditional energy benefit.
Formulation logic100
No missing partner or configured conflict was identified. The assessed ingredients meet the saved minimum amount check.
Partner coverage
The assessed ingredients do not depend on a missing partner for their assigned contribution.
Conflicts
No configured ingredient conflict was found in the supplied facts.
Effective doses
All ingredients included in this amount check clear its minimum comparison threshold; that threshold does not itself prove a noticeable benefit.
Vitamin B5 Not classified
No linked studies yet.
Impact
High effect
Folate · 667 mcg DFEVitamin B12 · 100 mcgVitamin B6 · 25 mgMolybdenum · 50 mcgSelenium · 100 mcgVitamin E · 67 mgZinc · 15 mgVitamin C · 125 mgRiboflavin · 25 mg
Folate and selenium can help address low intake, with toxin-related findings limited to folic acid in arsenic-exposed populations and particular selenium preparations in small mercury studies. Those results do not establish general toxin removal, and this product's forms do not all establish equivalence to those preparations. Its broader nutrient roles support normal metabolism without proving extra clearance when intake is adequate.
How this product is rated for Liver & Detox
Ingredient fit60
Folate and selenium provide the conditional nutritional connections within a broad vitamin and mineral formula.
Goal fit
Folate and selenium provide the conditional nutritional connections within a broad vitamin and mineral formula.
Dose adequacy
The qualifying nutrients contribute to the saved amount finding; vitamin C is below the counting threshold.
Pathways64
Methyl-group supply leads the saved findings.
Depth
Methyl-group supply leads the saved findings.
Breadth
Methyl-group supply and enzyme-related processes are substantially represented.
Evidence97
Folate leads the saved evidence finding. Molybdenum, riboflavin and vitamin B6 lack the saved studied-preparation finding.
Evidence strength
Folate leads the saved evidence finding; the supplied context limits what can be concluded about routine toxin clearance.
Studied preparation
Molybdenum, riboflavin and vitamin B6 lack the saved studied-preparation finding.
Formulation logic100
All eight credited ingredients meet the saved amount threshold. No configured conflict was identified.
Partner coverage
Every credited ingredient works alone or has its required partner in the saved findings.
Conflicts
No configured ingredient conflict was identified in the saved findings.
Effective doses
All eight credited ingredients meet the saved amount threshold.
Riboflavin Not classified
No linked studies yet.
Vitamin B6 Not classified
No linked studies yet.
Impact
High effect
Vitamin K · 100 mcgVitamin B12 · 100 mcgVitamin B6 · 25 mgFolate · 667 mcg DFEVitamin D · 50 mcg
Folate and related B vitamins support homocysteine metabolism, but lowering this marker has not generally prevented major cardiac events. Thiamin supports heart function when deficiency is responsible for disease; adequate intake does not imply further benefit. Selenium is relevant to deficiency-related heart disease, without established prevention benefits in adequately nourished adults.
How this product is rated for Heart Health
Ingredient fit65
Vitamin B9 (Folate), Vitamin B6, Vitamin B12, Selenium, Vitamin D, Vitamin B1 (Thiamin) provide the main connection to heart health; other active ingredients broaden the formula beyond this goal
Goal fit
Vitamin B9 (Folate), Vitamin B6, Vitamin B12, Selenium, Vitamin D, Vitamin B1 (Thiamin) provide the main connection to heart health; other active ingredients broaden the formula beyond this goal
Dose adequacy
The relevant amounts provide a partial contribution across the formula; higher amounts are not automatically more beneficial.
Pathways60
Homocysteine clearance is the strongest connection in the saved findings; this describes the ingredient roles, not a guaranteed effect.
Depth
Homocysteine clearance is the strongest connection in the saved findings; this describes the ingredient roles, not a guaranteed effect.
Breadth
The main areas represented are homocysteine clearance; other aspects have less support in this formula.
Evidence89
Vitamin B9 (Folate) provides the strongest relevant evidence here, with the population and benefit limits described above.
Evidence strength
Vitamin B9 (Folate) provides the strongest relevant evidence here, with the population and benefit limits described above.
Studied preparation
The contributing ingredient preparations match those recognized in the supplied comparison; this does not establish efficacy of the finished product.
Formulation logic100
The relevant ingredients do not depend on a missing partner in the supplied findings. No configured ingredient conflict was identified in the supplied findings.
Partner coverage
The relevant ingredients do not depend on a missing partner in the supplied findings.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
The contributing ingredients have meaningful declared amounts for comparison, without proving a cardiovascular benefit.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin A (Natural Mixed Carotenoids, Vitamin A Palmitate) | 2400 mcg RAE | |
Vitamin C (Ascorbic Acid, Ascorbyl Palmitate) | 125 mg | |
Vitamin D3 (Cholecalciferol) | 50 mcg | |
Vitamin E (D-Alpha-Tocopheryl Acid Succinate, Mixed Tocopherols) | 67 mg | |
Vitamin K (Vitamin K1, Vitamin K2) | 100 mcg | |
Thiamine (Thiamine Mononitrate) | 25 mg | |
Riboflavin (Riboflavin 5-Phosphate) | 25 mg | |
Niacin (Niacinamide) | 100 mg NE | |
Vitamin B-6 (Pyridoxal 5-Phosphate) | 25 mg | |
Folate (Calcium Salt, L-5-Methylfolate) | 667 mcg DFE | |
Vitamin B12 (Methylcobalamin) | 100 mcg | |
Biotin | 200 mcg | |
Pantothenic Acid (Calcium D-Pantothenate) | 100 mg | |
Iodine (Potassium Iodide) | 100 mcg | |
Zinc (Zinc Citrate) | 15 mg | |
Selenium (L-Selenomethionine) | 100 mcg | |
Copper (Copper Gluconate) | 1 mg | |
Manganese (Manganese Gluconate) | 5 mg | |
Chromium (Chromium Niacinate) | 100 mcg | |
Molybdenum (Molybdenum Glycinate) | 50 mcg | |
Betaine HCl | 25 mg | |
Boron (Boron Citrate) | 1 mg | |
Vanadium (Vanadyl Sulfate) | 50 mcg |
Vitamin B6 (Pyridoxal 5-Phosphate) · 25 mg OverallScore77
A serving contains 25 mg of vitamin B6, exceeding the European adult daily upper limit. The B6 is identified as Pyridoxal 5-Phosphate, and B6 from food or other supplements adds to the daily total.
How this ingredient is rated
Ingredient Form & Label Quality100
The vitamin B6 source is identified as Pyridoxal 5-Phosphate. The recorded check found no artificial dyes, titanium dioxide or talc.
Vitamin B6 Form Identification
The B6 source is identified as Pyridoxal 5-Phosphate.
Clean Label and Excipient Purity
The recorded check found no artificial dyes, titanium dioxide or talc.
Dose, Safety & Label Transparency60
The 25 mg of B6 per serving exceeds the European adult daily upper limit; other sources also contribute to daily intake. The label identifies Pyridoxal 5-Phosphate as the source.
Vitamin B6 Dose & Safety Policy
The 25 mg of B6 per serving exceeds the European adult daily upper limit; other sources also contribute to daily intake.
Label Transparency
The B6 source is disclosed as Pyridoxal 5-Phosphate.
Value64
The whole-product serving costs about $0.63 for 25 mg of B6, a moderate cost per mg in the comparison.
Vitamin B6 Price Efficiency
The whole-product serving costs about $0.63 for 25 mg of B6, a moderate cost per mg in the comparison.
Manganese (Manganese Gluconate) · 5 mg OverallScore82
A serving lists 5 mg of manganese as gluconate. The whole-product serving costs about $0.63.
How this ingredient is rated
Active Ingredient Quality & Bioavailability80
The declared form is manganese gluconate.
Manganese Chemical Form
The declared form is manganese gluconate.
Dose, Safety & Label Transparency100
A serving lists 5 mg of elemental manganese.
Manganese Dosage Efficacy & Safety
The declared serving contains 5 mg of manganese.
Elemental Weight Disclosure
The elemental manganese amount is declared as 5 mg per serving.
Value50
About $0.63 per whole-product serving covers the entire product, not manganese alone.
Price per Serving vs. Median
The price comparison uses about $0.63 per whole-product serving.
Selenium (L-Selenomethionine) · 100 mcg OverallScore77
A serving provides 100 mcg of selenium as l-selenomethionine. At the listed price, the product costs about $1.27 per 200 mcg of selenium for comparison.
How this ingredient is rated
Active Ingredient Quality & Bioavailability100
The selenium is identified as L-selenomethionine, with the L form specifically named.
Selenium Chemical Form
The recorded form is L-selenomethionine, an organic form of selenium.
Form Transparency & Isomer Specificity
The name specifies the L form of selenomethionine.
Dose, Safety & Label Transparency88
The serving provides 100 mcg of selenium. It falls below the upper limit used in the evaluation, though food and other sources also contribute to total intake.
Dosage Efficacy Sweet Spot
A serving supplies 100 mcg of selenium, an amount used for selenium support.
Safety Margin & UL Adherence
The 100 mcg in a serving is below the upper limit used in the evaluation; food and other products also contribute to total selenium intake.
Value10
At the listed price, about $1.27 of the whole product corresponds to 200 mcg of selenium. The cost also covers any other ingredients.
Price per 200 mcg Serving
At the listed price, about $1.27 of the whole product corresponds to 200 mcg of selenium. The cost also covers any other ingredients.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
- Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
- The relationship between boron and magnesium status and bone mineral density in the human: a review.
- Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
- Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
- The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
- Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
- Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
- The association between dietary mineral intake and bone mineral density: a cross-sectional study.
- Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
- Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
- Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
- Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
- Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
- Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
- Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
- The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
- Associations of multiple metals with bone mineral density: A population-based study in US adults.
- Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
- Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.